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Curriculum vitae

CURRICULUM VITAE
DANIELA COCCHI

-Full Professor of Pharmacology, Faculty of Medicine, University
of Brescia;
-Vice-Dean of the Faculty of Medicine of the University of Brescia;
-Director of the Research Center on Bone Metabolic Diseases and
Osteoporosis;
-past Chairperson of the Department of Biomedical Sciences and
Biotechnologies, University of Brescia.
Research interest:
-central regulation of anterior pituitary hormones, in particular
growth hormone and prolactin;
-central mechanisms involved in pubertal development;
-neuroendocrine alterations during senescence;
-neuroendocrine alterations in experimental obesity;
-role of ghrelin on bone remodelling.
Author of 200 publications on ISI journals and of several articles
on other journals and chapters of book on these topics.
She was a member of the Editorial Board of Pharmacological
Research and the Journal of Endocrinological Investigation.
List of publications since 1990
-Bresciani E, Pitsikas N, Tamiazzo L, Luoni M, Bulgarelli I. Cocchi D, Torsello
A, locatelli V
J Endocrinol Invest. 2008 Jul;31 (7): 647-52
-Tulipano G, Spano P, Cocchi D.
Effects of olanzapine on glucose transport, proliferation and survival in C2C12
myoblasts.
Mol Cell Endocrinol. 2008 Apr 25. [Epub ahead of print]
-Tulipano G, Taylor JE, Halem HA, Datta R, Dong JZ, Culler MD, Bianchi I,
Cocchi D, Giustina A.
Glucocorticoid inhibition of growth in rats: partial reversal with the
full-length ghrelin analog BIM-28125.

Pituitary. 2007;10(3):267-74.
-Tulipano G, Rizzetti C, Bianchi I, Fanzani A, Spano P, Cocchi D.
Clozapine-induced alteration of glucose homeostasis in the rat: the contribution
of hypothalamic-pituitary-adrenal axis activation.
Neuroendocrinology. 2007;85(2):61-70.
-Toni R, Della Casa C, Castorina S, Cocchi D, Celotti F.
Effects of hypothyroidism and endocrine disruptor-dependent non-thyroidal
illness syndrome on the GnRH-gonadotroph axis of the adult male rat.
J Endocrinol Invest. 2005;28(11 Suppl Proceedings):20-7. Review.
-Cocchi D, Maccarinelli G, Sibilia V, Tulipano G, Torsello A, Pazzaglia UE,
Giustina A, Netti C.
GH-releasing peptides and bone.
J Endocrinol Invest. 2005;28(8 Suppl):11-4. Review.
-Fraysse B, Desaphy JF, Rolland JF, Pierno S, Liantonio A, Giannuzzi V,
Camerino C, Didonna MP, Cocchi D, De Luca A, Conte Camerino D.
Fiber type-related changes in rat skeletal muscle calcium homeostasis during
aging and restoration by growth hormone.
Neurobiol Dis. 2006 Feb;21(2):372-80. Epub 2005 Sep 8.
-Maccarinelli G, Sibilia V, Torsello A, Raimondo F, Pitto M, Giustina A, Netti
C, Cocchi D.
Ghrelin regulates proliferation and differentiation of osteoblastic cells.
J Endocrinol. 2005 Jan;184(1):249-56.
-Tulipano G, Rossi E, Culler MD, Taylor JE, Bonadonna S, Locatelli V, Cocchi
D,Giustina A.
The somatostatin subtype-2 receptor antagonist, BIM-23627, improves the
catabolic effects induced by long-term glucocorticoid treatment in the rat.
Regul Pept. 2005 Feb 15;125(1-3):85-92.
-Tulipano G, Vergoni AV, Soldi D, Muller EE, Cocchi D.
Characterization of the resistance to the anorectic and endocrine effects of
leptin in obesity-prone and obesity-resistant rats fed a high-fat diet.
J Endocrinol. 2004 Nov;183(2):289-98.
- Buzi F, Maccarinelli G, Guaragni B, Ruggeri F, Radetti G, Meini A, Mazzolari
E, Cocchi D.
Serum osteoprotegerin and receptor activator of nuclear factors kB (RANKL)
concentrations in normal children and in children with pubertal precocity,
Turner's syndrome and rheumatoid arthritis.

Clin Endocrinol (Oxf). 2004 Jan;60(1):87-91.
- Pierno S, De Luca A, Desaphy JF, Fraysse B, Liantonio A, Didonna MP,
Lograno M, Cocchi D, Smith RG, Camerino DC.
Growth hormone secretagogues modulate the electrical and contractile
properties
of rat skeletal muscle through a ghrelin-specific receptor.
Br J Pharmacol. 2003 Jun;139(3):575-84.
- Torsello A, Bresciani E, Rossoni G, Avallone R, Tulipano G, Cocchi D,
Bulgarelli I, Deghenghi R, Berti F, Locatelli V.
Ghrelin plays a minor role in the physiological control of cardiac function in
the rat.
Endocrinology. 2003 May;144(5):1787-92.
- Perugini P, Genta I, Conti B, Modena T, Cocchi D, Zaffe D, Pavanetto F.
PLGA microspheres for oral osteopenia treatment: preliminary "in vitro"/"in
vivo"evaluation.
Int J Pharm. 2003 Apr 30;256(1-2):153-60.
- Torsello A, Scibona B, Leo G, Bresciani E, Avallone R, Bulgarelli I, Luoni
M,Zoli M, Rindi G, Cocchi D, Locatelli V.
Ontogeny and tissue-specific regulation of ghrelin mRNA expression suggest
that ghrelin is primarily involved in the control of extraendocrine functions in
the rat.
Neuroendocrinology. 2003 Feb;77(2):91-9.
- Bagnasco M, Tulipano G, Melis MR, Argiolas A, Cocchi D, Muller EE.
Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in
response to fasting.
Regul Pept. 2003 Mar 28;111(1-3):161-7.
- Torri C, Pedrazzi P, Leo G, Müller EE, Cocchi D, Agnati LF, Zoli M.
Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat
hypothalamus.
Peptides. 2002 Jun;23(6):1063-8.
- Rindi G, Savio A, Torsello A, Zoli M, Locatelli V, Cocchi D, Paolotti D,
Solcia E.
Ghrelin expression in gut endocrine growths.
Histochem Cell Biol. 2002 Jun;117(6):521-5.
- Rindi G, Necchi V, Savio A, Torsello A, Zoli M, Locatelli V, Raimondo F,
Cocchi D, Solcia E.

Characterisation of gastric ghrelin cells in man and other mammals: studies in
adult and fetal tissues.
Histochem Cell Biol. 2002 Jun;117(6):511-9.
- Sibilia V, Cocchi D, Villa I, Lattuada N, Soglian A, Rubinacci A, Muller EE,
Pecile A, Netti C.
Bone effects of hexarelin, a GH-releasing peptide, in female rats: influence of
estrogen milieu.
Eur J Endocrinol. 2002 Jun;146(6):855-62.
- Tulipano G, Soldi D, Bagnasco M, Culler MD, Taylor JE, Cocchi D, Giustina
A.
Characterization of new selective somatostatin receptor subtype-2 (sst2)
antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in
anesthetized male rats after short-term high-dose dexamethasone treatment.
Endocrinology. 2002 Apr;143(4):1218-24.
- Maccarinelli G, Belotti R, Savoldi E, Gervasoni M, Cocchi D.
Phagocytosis and killing of Candida albicans of polymorphonuclear cells in
patients with organ transplant of periodontal disease.
Minerva Stomatol. 2001 Nov-Dec;50(11-12):345-9.
- Sibilia V, Cocchi D, Pagani F, Pecile A, Netti C.
The influence of sex and gonadectomy on the growth hormone and
corticosterone
response to hexarelin in the rat.
Life Sci. 2000 Dec 8;68(3):321-9.
- De Gennaro-Colonna V, Rossoni G, Cocchi D, Rigamonti AE, Berti F, Muller
EE.
Endocrine, metabolic and cardioprotective effects of hexarelin in obese Zucker
rats.
J Endocrinol. 2000 Sep;166(3):529-36.
- Sibilia V, Cocchi D, Pagani F, Lattuada N, Moro GL, Pecile A, Rubinacci A,
Muller EE, Netti C.
Hexarelin, a growth hormone - releasing peptide, counteracts bone loss in
gonadectomized male rats.
Growth Horm IGF Res. 1999 Aug;9(4):219-27.
- Cocchi D, De Gennaro Colonna V, Bagnasco M, Bonacci D, Müller EE.
Leptin regulates GH secretion in the rat by acting on GHRH and
somatostatinergic
functions.

J Endocrinol. 1999 Jul;162(1):95-9.
- Zaffe D, Paganelli C, Cocchi D.
Induction and pharmacological treatment of oral osteopenia in rats.
Minerva Stomatol. 1999 Mar;48(3):45-62. English, Italian.
- Müller EE, Locatelli V, Cocchi D.
Neuroendocrine control of growth hormone secretion.
Physiol Rev. 1999 Apr;79(2):511-607. Review.
- Zoli M, Picciotto MR, Ferrari R, Cocchi D, Changeux JP.
Increased neurodegeneration during ageing in mice lacking high-affinity
nicotine
receptors.
EMBO J. 1999 Mar 1;18(5):1235-44.
- De Luca A, Pierno S, Camerino C, Cocchi D, Camerino DC.
Higher content of insulin-like growth factor-I in dystrophic mdx mouse:
potential
role in the spontaneous regeneration through an electrophysiological
investigation of muscle function.
Neuromuscul Disord. 1999 Jan;9(1):11-8.
- Pedrazzi P, Cattaneo L, Valeriani L, Boschi S, Cocchi D, Zoli M.
Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria
diet.
Peptides. 1998;19(1):157-65.
- Cattaneo L, Luoni M, Settembrini B, Müller EE, Cocchi D.
Effect of long-term administration of Hexarelin on the somatotrophic axis in
aged
rats.
Pharmacol Res. 1997 Jul;36(1):49-54.
- De Luca A, Pierno S, Cocchi D, Conte Camerino D.
Effects of chronic growth hormone treatment in aged rats on the biophysical
and pharmacological properties of skeletal muscle chloride channels.
Br J Pharmacol. 1997 Jun;121(3):369-74.
-Müller EE, Cella SG, Rigamonti AE, degli Uberti EC, Ambrosio MR, Cocchi D.
Aspects of the central nervous drive to growth hormone secretion during aging.
Aging (Milano). 1997;9(4 Suppl):7-8. Review.
- Cattaneo L, De Gennaro Colonna V, Zoli M, Müller EE, Cocchi D.

Hypothalamo-pituitary-IGF-1 axis in female rats made obese by overfeeding.
Life Sci. 1997;61(9):881-9.
- Cattaneo L, De Gennaro Colonna V, Zoli M, Müller E, Cocchi D.
Characterization of the hypothalamo-pituitary-IGF-I axis in rats made obese by
overfeeding.
J Endocrinol. 1996 Feb;148(2):347-53.
- Cattaneo L, Muller EE, Cocchi D.
In vivo microdialysis of the hypothalamus: a suitable method to study the
function of hypophysiotropic neurons in the rat.
J Neuroendocrinol. 1996 Jan;8(1):31-3.
- Müller EE, Cella SG, Parenti M, Deghenghi R, Locatelli V, De Gennaro
Colonna V, Torsello A, Cocchi D.
Somatotropic dysregulation in old mammals.
Horm Res. 1995;43(1-3):39-45. Review.
- Ghigo E, Bartolotta E, Imperiale E, Bellone J, Cardinale G, Aimaretti G,
Valetto MR, Cherubini V, Maccario M, Cocchi D, et al.
Glucagon stimulates GH secretion after intramuscular but not intravenous
administration. Evidence against the assumption that glucagon per se has a
GH-releasing activity.
J Endocrinol Invest. 1994 Dec;17(11):849-54.
-De Gennaro Colonna V, Cella SG, Parenti M, Locatelli V, Cocchi D, Müller EE.
Neuroendocrine aging: its impact on somatotrophic function.
Neurochem Int. 1994 Jul;25(1):5-10.
- De Luca A, Pierno S, Cocchi D, Conte Camerino D.
Growth hormone administration to aged rats improves membrane electrical
properties of skeletal muscle fibers.
J Pharmacol Exp Ther. 1994 Jun;269(3):948-53.
- Qing Y, Parenti M, Guzzi F, Ceresoli G, Müller EE, Cocchi D.
Alterations of adenylyl cyclase-coupled growth hormone-releasing hormone
(GHRH)
pituitary receptors in different conditions of GHRH deprivation.
Brain Res. 1994 Apr 25;644(1):13-8.
- Ghigo E, Ceda GP, Valcavi R, Goffi S, Zini M, Mucci M, Valenti G, Cocchi D,
Müller EE, Camanni F.
Low doses of either intravenously or orally administered arginine are able to

enhance growth hormone response to growth hormone releasing hormone in
elderly subjects.
J Endocrinol Invest. 1994 Feb;17(2):113-7.
46: Cattaneo L, Bondiolotti GP, Muller EE, Cocchi D.
Effect of acute and short-term administration of cholinomimetic drugs on
corticosterone secretion in the rat.
Eur J Pharmacol. 1993 Sep 14;241(2-3):245-8.
- de Gennaro Colonna V, Fidone F, Cocchi D, Müller EE.
Feedback effects of growth hormone on growth hormone-releasing hormone
and somatostatin are not evident in aged rats.
Neurobiol Aging. 1993 Sep-Oct;14(5):503-7.
- Cocchi D, Parenti M, Cattaneo L, De Gennaro Colonna V, Zocchetti A, Müller
EE.
Growth hormone secretion is differently affected in genetically obese male and
female rats.
Neuroendocrinology. 1993 May;57(5):928-34. Erratum in: Neuroendocrinology
1994 Jan;59(1):84.
- Müller EE, Cocchi D, Ghigo E, Arvat E, Locatelli V, Camanni F.
Growth hormone response to GHRH during lifespan.
J Pediatr Endocrinol. 1993 Jan-Mar;6(1):5-13. Review.
- Müller EE, Cella SG, De Gennaro Colonna V, Parenti M, Cocchi D, Locatelli
V.
Aspects of the neuroendocrine control of growth hormone secretion in ageing
mammals.
J Reprod Fertil Suppl. 1993;46:99-114. Review.
- Cocchi D.
Age-related alterations in gonadotropin, adrenocorticotropin and growth
hormone
secretion.
Aging (Milan). 1992 Jun;4(2):103-13. Review.
- Cocilovo L, de Gennaro Colonna V, Zoli M, Biagini G, Settembrini BP, Müller
EE, Cocchi D.
Central mechanisms subserving the impaired growth hormone secretion
induced by persistent blockade of NMDA receptors in immature male rats.
Neuroendocrinology. 1992 Apr;55(4):416-21.
- Cocchi D, Bardone MR, Moretti R, Travaglini P.

Effect of Thymomodulin on luteinizing hormone, prolactin and testosterone in
male rats.
Thymus. 1992 Feb;19(1):53-8.
- Lamperti E, Cocchi D, Parati EA, Caraceni T, Müller EE.
Growth hormone responses to cholinergically active drugs in patients with
dementia of the Alzheimer type.
Alzheimer Dis Assoc Disord. 1992 Spring;6(1):44-52.
- Ghigo E, Maccario M, Arvat E, Valetto MR, Valente F, Nicolosi M, Mazza E,
Martina V, Cocchi D, Camanni F.
Interactions of galanin and arginine on growth hormone, prolactin, and insulin
secretion in man.
Metabolism. 1992 Jan;41(1):85-9.
- Parenti M, Cocchi D, Ceresoli G, Marcozzi C, Müller EE.
Age-related changes of growth hormone secretory mechanisms in the rat
pituitary gland.
J Endocrinol. 1991 Nov;131(2):251-7.
- Rossi GL, Bestetti GE, Galbiati E, Müller EE, Cocchi D.
Sexually dimorphic effects of aging on rat somatotropes and lactotropes.
J Gerontol. 1991 Jul;46(4):B152-8.
- Ferrara C, Ceresoli G, Marcozzi C, Cocchi D.
Hypothalamo-pituitary somatostatinergic system in middle-aged female rats.
Horm Metab Res. 1991 May;23(5):243-4.
- Ferrara C, Cocchi D, Müller EE.
Somatostatin in the hippocampus mediates dexamethasone-induced suppression
of corticosterone secretion in the rat.
Neuroendocrinology. 1991 Apr;53(4):428-31. Erratum in: Neuroendocrinology
1991
- De Gennaro Colonna V, Bertola G, Coco CB, Bifano M, Cocchi D, Maggi A,
MüllerEE.
Hypothalamic-pituitary somatotropic function in prepubertal hypothyroid rats:
effect of growth hormone replacement therapy.
Proc Soc Exp Biol Med. 1991 Apr;196(4):432-7.
- De Gennaro Colonna V, Cocchi D, Lima L, Maggi A, Müller EE.
Testosterone and GHRH gene expression in adult and old rats.
Peptides. 1991 Mar-Apr;12(2):309-12.

- Franco P, Marelli O, Lattuada D, Locatelli V, Cocchi D, Müller EE.
Influence of growth hormone on the immunosuppressive effect of prednisolone
in mice.
Acta Endocrinol (Copenh). 1990 Sep;123(3):339-44.
- Ceresoli G, Parenti M, Marcozzi C, Cocchi D, Müller EE.
Age-related changes of GHRF and somatostatin cell signalling pathways
operating in the rat pituitary gland.
Pharmacol Res. 1990 Sep-Oct;22 Suppl 3:15-6.
- De Gennaro Colonna V, Bertola G, Coco CB, Bifano M, Cocchi D, Maggi A,
Müller EE.
Changes in the hypothalamic-pituitary somatotropic function of infant
hypothyroid rats.
Proc Soc Exp Biol Med. 1990 Mar;193(3):214-9.
- Veneroni O, Cocilovo L, Müller EE, Cocchi D.
Delay of puberty and impairment of growth in female rats given a non
competitive
antagonist of NMDA receptors.
Life Sci. 1990;47(14):1253-60.

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