Curriculum vitae
JAMES THOMAS SUMMERSGILL, Ph.D.
PROFESSOR OF MEDICINE
Address:
Department of Medicine University of Louisville Louisville, Kentucky 40292 USA (40202 for Express Courier) Telephone: 502-852-5132 Facsimile: 502-852-1512 E-Mail:
[email protected]
Born: August 17, 1951
Montgomery, Alabama, USA United States Citizen
Education:
Ph.D. 1988 University of Louisville, Louisville, Kentucky, Department of Microbiology
M.S. 1975 Murray State University, Murray, Kentucky Major: Biology
B.S. 1973 Murray State University, Murray, Kentucky
Professional Career:
2003-Present: Professor of Medicine and Director, Infectious Diseases
Laboratory, Division of Infectious Diseases, University of Louisville School
of Medicine, Louisville, Kentucky
1996-2003: Associate Professor of Medicine and Director, Infectious Diseases
Laboratory, Division of Infectious Diseases, University of Louisville School
of Medicine, Louisville, Kentucky
1995-Present: Associate in Department of Microbiology and Immunology, University of
Louisville School of Medicine, Louisville, Kentucky
1990-1996: Assistant Professor of Medicine and Director, Infectious Diseases
Laboratory, Division of Infectious Diseases, University of Louisville School
of Medicine, Louisville, Kentucky
1989-1990: Research Associate and Supervisor, Infectious Diseases Laboratory,
University of Louisville School of Medicine, Louisville, Kentucky
1980-1984: Instructor, Division of Natural Sciences, Jefferson Community College,
Louisville, Kentucky
1978-1989: Senior Research Technologist and Supervisor, Infectious Diseases
Laboratory, University of Louisville School of Medicine, Louisville, Kentucky
1976-1978: Research Assistant, Division of Infectious Diseases, University of Louisville
School of Medicine, Louisville, Kentucky
Memberships:
American Society for Microbiology Infectious Diseases Society of America Chlamydia Basic Research Society
Professional Activities:
Chair-Elect, Division D (General Medical Microbiology), American Society for Microbiology.
Chair, Division D (General Medical Microbiology), American Society for Microbiology.
Reviewer (Ad hoc), Bacteriology and Mycology 1 Study Section
National Institutes of Health, Bethesda, MD
2001-2003 Member, Data Safety and Monitoring Board, ACES Study, National Heart,
Councillor, Chlamydia Basic Research Society
University Service:
Member, Promotion, Appointment and Tenure Committee
University of Louisville School of Medicine.
Students Trained:
Publications:
Raff MJ,
Summersgill JT, Fontana FJ, Barnwell PA, Waterman NG & Scharfenberger L.
Effects of serum lipid content on the binding of minocyline. J Antibiot 30:593-596,1977.
Raff MJ, Melo JC, Chun CH,
Summersgill JT & Varghese R. Metronidazole therapy of
Bacteroides fragilis osteomyelitis. Amer. J. Med. Sci., 280:143-149, 1980.
Courtney MA, Miller JR,
Summersgill JT, Raff MJ & Streips UN. R-factor responsible
for an outbreak of multiple antibiotic-resistant
Klebsiella pneumoniae. Antimicrob.
Agents Chemother. 18:926-929, 1980.
Raff MJ &
Summersgill JT. Functional chemical alterations in non-penicillin
beta-lactam compounds. Process Biochem. 16:15-23, 1981.
Raff MJ,
Summersgill JT & Barnwell PA. Comparative in vitro evaluation of
moxalactam against recent clinical isolates. Cur. Therap. Res. 30:277-291,1981.
Summersgill
JT, Schupp LG & Raff MJ. Comparative penetration of metronidazole,
clindamycin, chloramphenicol, cefoxitin, ticarcillin and moxalactam into bone.
Antimicrob.Agents Chemother. 21:601-603, 1982.
Summersgill JT, Burke RD, Waterman NG & Raff MJ. Concentrations of
moxalactam in serum and interstitial fluid in dogs. Chemioterapia 1:454-456, 1982.
Summersgill JT, Harrod LG & Raff MJ. Azlocillin and cefonicid penetration into bone
enhanced by probenecid. Antimicrob. Agents Chemother. 26:292-294,1984.
Johnson JD,
Summersgill JT & Raff MJ. The in vitro effects of methotrexate on the
phagocytosis and intracellular killing of
S. aureus by human neutrophils. Cancer
12:2343-2347, 1986.
Summersgill JT, Raff MJ & Miller RD. Interactions of virulent and avirulent
Legionella
pneumophila with human polymorphonuclear leukocytes. Microb. Pathogen.
5:41-47, 1988.
Summersgill JT, Raff MJ & Miller RD. Interactions of virulent and avirulent
Legionella
pneumophila with human monocytes. J. Leukocyte Biol. 46:31-38, 1989.
Sahney NN, Lambe BC,
Summersgill JT & Miller RD. Inhibition of polymorphonuclear
leukocyte function by
Legionella pneumophila exoproducts. Microb. Pathogen.
9:117-125,1990.
Silk KL, Ali MB, Cohen BJ,
Summersgill JT & Raff MJ. Absence of Bacteremia During
Nasal Septoplasty. Arch. Otolaryngol. Head Neck Surg. 117:54-55, 1991.
Buck GE, O'Hara LC &
Summersgill JT. A rapid,simple method for treating clinical
specimens containing
Mycobacterium tuberculosis to remove DNA for polymerase chain
reaction. J. Clin. Microbiol. 30:1331-1334,1992.
Buck GE, O'Hara LC &
Summersgill JT. Rapid, sensitive detection of
Mycoplasma
pneumoniae in simulated clinical specimens by DNA amplification. J. Clin. Microbiol.
30:3280-3283, 1992.
Summersgill JT, Powell LA, Buster BL, Miller RD & Ramirez JA. Killing of
Legionella
pneumophila by nitric oxide in interferon activated macrophages. J. Leukocyte Biol.
52:625-629, 1992.
Ramirez JA,
Summersgill JT, Miller RD, Meyers TL & Raff MJ. Bactericidal activity of
imipenem compared to erythromycin against intracellular
Legionella pneumophila. Drugs
Exptl. Clin. Res. 18:407-410, 1992.
Ramirez JA,
Summersgill JT, Miller RD, Meyers TL & Raff MJ. Comparative study of
the bactericidal activity of ampicillin/sulbactam and erythromycin against intracellular
Legionella pneumophila. J. Antimicrob. Chemother. 32:93-99, 1993.
Ramirez JA &
Summersgill JT. Rapid tests for the diagnosis of
Legionella infections. J.
Ky.Med. Assoc. 92:62-65, 1994.
Summersgill, JT, Gaydos, CA, Sahney, NN, Quinn, TC & Ramirez, JA. Inhibition of
Chlamydia pneumoniae growth in Hep2 cells pretreated with interferon gamma and
tumor necrosis factor alpha. Infect. Immun. 63:2801-2803, 1995.
Ramirez JA, Ahkee S, Tolentino A, Miller RD &
Summersgill JT. Diagnosis of
Legionella pneumophila, Mycoplasma pneumoniae or
Chlamydia pneumoniae lower
respiratory infection using the polymerase chain reaction on a single throat swab
specimen. Diagn. Microbiol. Infect. Dis. 24:7-14, 1996.
Gaydos CA,
Summersgill JT, Sahney NN, Ramirez JA & Quinn TC. Replication of
Chlamydia pneumoniae in vitro in human macrophages, endothelial cells and aortic
artery smooth muscle cells. Infect. Immun. 64:1614-1620, 1996.
Emre U, Bernius M, Roblin P, Gaerlan PF,
Summersgill JT, Steiner P, Schachter J &
Hammerschlag MR.
Chlamydia pneumoniae infection in patients with cystic fibrosis.
Clin. Infect. Dis. 22:819-823, 1996.
Ramirez JA, Ahkee S,
Summersgill JT, Ganzel BL, Ogden LL, Quinn TC, Gaydos CA,
Bobo LL, Hammerschlag MR, Roblin PM, LeBar W, Grayston JT, Kuo CC, Campbell LA,
Patton DL, Dean D & Schachter J. Isolation of
Chlamydia pneumoniae from the
coronary artery of a patient with coronary atherosclerosis. Ann. Intern. Med. 125:979-
982, 1996.
Pinar AP, Ahkee S, Miller RD,Ramirez JA &
Summersgill JT. Use of heteroduplex
analysis to classify Legionellae on the basis of 5S rRNA gene sequences. J. Clin.
Microbiol. 35:1609-1611, 1997.
Molestina RE, Miller RD, Ramirez JA &
Summersgill JT. Characterization of a strain of
Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1
gene and biological activity in human endothelial cells. Infect. Immun., 66:1370-1376,
1998
.
Mehta SJ, Miller RD, Ramirez JA &
Summersgill JT. Inhibition of
Chlamydia
pneumoniae replication in HEp-2 cells: role of tryptophan catabolism. J. Infect.
Dis.177:1326-1331 , 1998.
Coxon, PL,
Summersgill JT, Ramirez JA & Miller RD. Signal transduction during
Legionella pneumophila entry into human monocytes.Infect. Immun., 66:2905-
2913,1998.
Molestina RE, Miller RD, Ramirez JA &
Summersgill JT. Infection of endothelial cells
with
Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and
monocytes. Infect. Immun., 67:1323-1330, 1999
Molestina RE, Miller RD, Lentsch AB, Ramirez JA &
Summersgill JT. Requirement of
NF-B for MCP-1 mRNA in
Chlamydia pneumoniae Infected Endothelial Cells. Infect.
Immun., 68:4282-4288. 2000.
Summersgill JT, Molestina RE, Miller RD & Ramirez JA. Interactions of Chlamydia
pneumoniae with human endothelial cells. J. Infect. Dis. , 181(Suppl 3):S479-482, 2000.
Collaborative Multidisciplinary Workshop Report: Interface of Lipid Metabolism,
Atherosclerosis, and Chlamydia Infection.
Byrne GI. Skarlotos SI. Grunfeld C. Kalayoglu MV. Libby P. Saikku P. Summersgill JT. Wyrick P. Collaborative multidisciplinary workshop report: interface of lipid metabolism, atherosclerosis, and Chlamydia infection. J Infect Dis.
181 (Suppl 3):S490-1, 2000.
Vergis, EN, Indorf A, File TM, Phillips J, Bates J, Tan J, Sarosi, GA, Grayston JT,
Summersgill JT & Yu VL. Azithromycin vs cefuroxime plus erythromycin for empirical
treatment of community-acquired pneumonia in hospitalized patients. A prospective,
randomized, multicenter trial. Arch Intern Med, 160:1294-1300, 2000.
Pantoja LG, Molestina RE, Miller RD, Ramirez JA &
Summersgill JT. Inhibition of
Chlamydia pneumoniae replication in human aortic smooth muscle cells by interferon-
gamma-induced indoleamine 2,3-dioxygenase acitivity. Infect. Immun. 68:6478-
6481,2000.
Sahney NN,
JT Summersgill, JA Ramirez & RD Miller. Inhibition of oxidative burst and
chemotaxis in human phagocytes by
Legionella pneumophila zinc metalloprotease. J.
Med. Microbiol. 50:517-525, 2001.
Pantoja LG, Molestina RE, Miller RD, Ramirez JA &
Summersgill JT. Characterization
of Chlamydia pneumoniae persistence in HEp2 cells treated with gamma interferon.
Infect. Immun. 69:7927-7932,2001.
Uriate, SM, RE Molestina, RD Miller, J Bernabo, A Farinati, K Eiguchi,JA Ramirez &
JT
Summersgill. Effect of Macrolide Antibiotics on Human Endothelial Cells Activated by
Chlamydia pneumoniae Infection and Tumor Necrosis Factor-alpha. J. Infect. Dis.
185:1631-1636, 2002.
Pinar, A, JA Ramirez, LL Schindler, RD Miller &
JT Summersgill. The use of
heterodulplex analysis of polymerase chain reaction products to support the possible
transmission of
Legionella pneumophila from a malfunctioning automobile air
conditioner. Infect Cont Hosp Epidemiol, 23(3):145-146,2002.
Molestina RE, Klein JB, Miller RD, WH Peirce, Ramirez JA &
Summersgill JT. Proteomic anlaysis of differentially expressed
Chlamydia pneumoniae genes during
persistent infection of HEp2 cells. Infect Immun 70:2976-2981,2002.
Cherneski M, M Smieja, J Schachter,
J Summersgill, L Schindler, K Campbell, LA
Campbell, A Cuppuccio, C Gaydos, S Chong, J Moncada, J Philips, D Jang, BJ Wood, A
Petrich, M Hammerschlag, M Cerney and J Mahony. Coomparison of an Industry-
derived LCx
Chlamydia pneumonia PCR research kit to in-house assays performed in
five laboratories. J. Clin. Microbiol. 40:2357-2362, 2002.
Yu, VL; Plouffe, JF; Pastoris, MC; Stout, JE; Schousboe, M; Widmer, A;
Summersgill,
J; File, T; Heath, CM; Paterson, DL; Chereshsky, A. Distribution of Legionella species
and serogroups isolated by culture in patients with sporadic community-acquired
legionellosis: An international collaborative survey. J. Infect Dis 186 (1): .127-128,
2002.
Hammerschlag MR, Reznik T, Roblin PM, Ramirez J,
Summersgill JT & Bukofzer S.
Microbiological efficacy of ABT-773 (cethromycin) for the treatment of community-
acquired pneumonia due to
Chlamydia pneumoniae. J. Antimicrob. Chemo. 2003.
Mukhopadhyay S, RD Miller &
JT Summersgill. Analysis of altered protein expression
patterns of
Chlamydia pneumoniae by an integrated proteom-works system. J. Proteome
Res. 2004.
Mukhopadhyay S, AP Clark, ED Sullivan, RD Miller &
JT Summersgill. Purification of
Chlamydia pneumoniae Elementary Bodies: A Detailed Protocol. J. Clin. Microbiol. 2004.
Hogan RJ, SA Mathews, S Mukhopadhyay,
JT Summersgill & P Timms. Chlamydial
Persistence: Beyond the biphasic paradigm. Infect. Immun. 72:1843-1855, 2004.
Uriarte SM, RE Molestina, RD Miller, J Bernabo, A Farinati, K Eiguchi, JA Ramirez &
JT
Summersgill. Effects of fluoroquinolone antibiotics on the migration of human
phagocytes through
Chlamydia pneumoniae-infected and tumor necrosis factor alpha-
stimulated endothelial cells. Antimicrob. Agents Chemother. 2004.
Welsh CT,
JT Summersgill & RD Miller. Increases in c-Jun N-terminal Kinase/Stress-
activated protein kinase and p38 activity in monocyte-derived macrophages following the
uptake of
Legionella pneumophila. Infect. Immun. 72:1512-1518, 2004.
Polkinghorne, A, RJ Hogan, L Vaughan,
JT Summersgill & P Timms. Differential
expression of chlamydial signal transduction genes in normal and interferon gamma-
induced persistent
Chlamydophila pneumonoiae infections. Microbes Infect. 8(1):61-72,
2006.
Mukhopadhyay S, RD Miller, E Sullivan, C Theodoropolus, S Matthews, P Timms and
JT Summersgill, Protein expression profiles of
Chlamydia pneumoniae in models of
persistence versus those of heat shock stress response. Infect. Immun. 74:3853-3863,
2006.
Mukhopadhyay S, SA Jortani, R Valdes Jr., CQ Simmons, ED Sullivan, RD Miller and
JT
Summersgill. Protein Expression Analysis of
Chlamydia pneumoniae Persistence by
Combined SELDI TOF-MS and 2D PAGE. Clinical Proteomics, 2(3-4), 205-216, 2006.
Mukhopadhyay S, D Good, RD Miller, JE Graham, SA Mathews, P Timms and
JT
Summersgill. Identification of
Chlamydia pneumoniae Proteins in the Transition From
Reticulate to Elementary Body Formation. Mol. Cell. Proteomics, In Press, 2006.
Borel, N, S Mukhopadhyay, C Kaiser, ED Sullivan, RD Miller, P Timms,
JT
Summersgill, JA Ramirez and A Pospischil. Tissue MicroArray (TMA) analysis of
normal and persistent
Chlamydophila pneumoniae infection. BMC Infectious Diseases,
6:152, 2006.
Arnold FW,
JT Summersgill, AS LaJoie, P Peyrani, TJ Marrie, P Rossi, F Blasi, P
Fernandez, TM File, Jr, J Rello, R Menendez, L Marzoratti, CM Luna, JA Ramirez and
CAPO Investigators. A Worldwide Perspective of Atypical Pathogens in Community-
Acquired Pneumonia. Am. J. Respir. Crit. Care Med.175:1086-1093, 2007.
Borel N,
JT Summersgill, S Mukhopadhyay, RD Miller, JA Ramirez and A Pospischil.
2007. Evidence for persistenct
Chlamydia pneumoniae infection of human coronary
atheromas. Atherosclerosis. In Press.
Bunk S, I Susnea, J Rupp,
JT Summersgill, M Maass, W Stegmann, A Schrattenholz
and C. Hermann. 2008. Immunoproteomic identification and serological responses to
novel
Chlamydia pneumoniae antigens that are associated with persistent
Chlamydia
pneumoniae infections. J. Immunol. 180:5490-5498.
Mathews, S, S Mukhopadhyay,
JT Summersgill, C Theodoropoulos, C Wan,and P
Timms. 2008. Differential transcriptional responses between the gamma interferon
induction and iron-limitation models of persistence in
Chlamydia pneumoniae. J.
Microibiol. Immunol Infection, 2009 Feb;42(1):27-37.
Borel N, A Pospischil, R Dowling, C Dumrese,C Gaydos, S Bunk, C Hermann, J
Ramirez and
JT Summersgill. 2012. Antigens of persistenct
Chlamydia pneumoniae within coronary atheroma from patients undergoing heart transplantation. J Clin Path
65:171-175 .
Book Chapters:
Ramirez, JA &
JT Summersgill. Community-Acquired Pneumonia Due to
Chlamydia
pneumoniae. In Community-Acquired Pneumonia. Thomas J. Marrie, Ed., Klwer
Academic/Plenum Publishers, New York, New York, 2001.
Huang, SH, A Jong &
JT Summersgill. Infectomic Analysis of Microbial Infections
Using Proteomics. pp.347-356. In Handbook of Proteomic Methods. P. Michael Conn,
Ed., Humana Press, Totowa, NJ, 2003.
Abstracts:
1.
Effects of delta-9-tetrahydrocannabinol on
Bacillus cereus ATCC4342. Muma L, Abbott
DO,
Summersgill JT & Daniel RE. 75th Annual Meeting of the American Society for
Microbiology, New York, New York, April 1975.
Effects of delta-9-tetrahydrocannabinol on
Tetrahymena pyroformis GL.
Summesgill
JT, Daniel RE, Muma L & Abbott DO. Annual Meeting of the Kentucky Academy of
Sciences. Louisville,Kentucky, November 1975.
Effects of probenecid on the protein binding of cephalosporin antibiotics.
Summersgill
JT, Raff MJ,Waterman NG, Scharfenberger L & Barnwell PA. 17th Interscience
Conference on Antimicrobial Agents and Chemotherapy. New York, NY, October 1977.
BL-S786R - a new semisynthetic cephalosporin derivative:clinical evaluation. Raff MJ,
Melo JC,Chun CH, Varghese R &
Summersgill JT. 18th Interscience Conference on
Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, October 1978.
Clinical evaluation of metronidazole in the treatment of osteomyelitis caused by
Bacteroides fragilis. Raff MJ, Melo JC, Chun CH, Varghese R &
Summersgill JT. 18th
Interscience Conference onAntimicrobial Agents and Chemotherapy. Atlanta, Georgia,
October 1978.
Multiple antibiotic resistance in clinical isolates of
Klebsiella pneumoniae. Courtney MA,
Summersgill JT, Raff MJ & Streips UN. Regional Meeting of the Indiana, Ohio and
Kentucky-Tennessee Branches of the American Society for Microbiology, Louisville, KY,
Isolation and characterization of R-factors from hospital strains of
Klebsiella
pneumoniae. Courtney MA, Miller JR,
Summersgill JT, Melo JC, Raff MJ & Streips
UN. 79th Annual Meeting of the American Society for Microbiology, Los Angeles,
California, May 1979.
Comparative evaluation of LY127935 against recent isolates.
Summersgill JT, Melo
JC & Raff MJ.Annual Meeting of the Tri-State Infectious Diseases Society Lexington,
Kentucky, May 1979.
Concentrations of moxalactam in serum and interstitial fluid in dogs.
Summersgill JT &
MJ Raff. 12th International Congress of Chemotherapy. Florence, Italy, July 1981.
Metronidazole penetration into bone.
Summersgill JT & Raff MJ. 21st Interscience
Conferenceon Antimicrobial Agents and Chemotherapy. Chicago, Illinois, November
1981.
Cefonicid penetration into bone enhanced by probenecid.
Summersgill JT, Harrod LG
& Raff MJ. 6th International Symposium on Future Trends in Chemotherapy. Tirrenia,
Italy, May 1984.
Enhanced phagocytosis in patients with aquired immunodefficiency syndrome (AIDS).
Johnson JD &
Summersgill JT. 2nd Int'l Conference on AIDS. Paris, France, June,
1986.
Effects of sex steroid hormones on neutrophil and monocyte functions. Kimmey M,
Johnson JD &
Summersgill JT. FASEB, Washington, D.C., March, 1987.
Virulent
Legionella pneumophila stimulate the oxidative response of human monocytes
and neutrophils to a lesser degree than avirulent variants.
Summersgill JT, Raff MJ &
Miller RD.
88th Annual Meeting, American Society for Microbiology, Miami Beach,
Hormone-like molecules expressed in vitro by
Legionella pneumophila.
Summersgill
JT, Carstens PHB, Miller RD & Robinson, Jr EN. 88th ASM, Miami Beach, FL, May
1988.
Inhibition of polymorphonuclear leukoctye (PMN) function by
Legionella pneumophila
exoproducts.Sahney N,
Summersgill JT, Raff MJ & Miller RD. 89th Annual Meeting,
American Society for Microbiology, New Orleans, LA, May 1989.
Legionella urinary antigen detection combined with direct fluorescent antibody and
culture for the diagnosis of Legionnaires' disease. Navarra BJ &
Summersgill JT. 90th
Annual Meeting, American Society for Microbiology, Dallas, TX, May 1991.
Intracellular free calcium responses in human neutrophils infected with
Legionella
pneumophila.Buster B,
Summersgill JT & Miller R. 91st Annual Meeting, American
Society for Microbiology,Dallas, TX, May 1991.
Role of Nitric Oxide in Killing of
Legionella pneumophila in Gamma-Interferon Activated
Macrophages. Buster B, Powell L, Ramirez JA, Miller R &
Summersgill JT. Fourth
International Symposium on Legionella. Orlando, FL, January 1992.
Inhibition of Oxidative Burst and Chemotaxis in Human Phagocytes by
Legionella
pneumophila Protease. Sahney N,
Summersgill JT & Miller R. Fourth International
Symposium on Legionella,Orlando, FL, January 1992.
Comparative Bactericidal Activity of Ampicillin/Sulbactam and Erythromycin Against
Intracellular
Legionella pneumophila. Ramirez JA,
Summersgill JT & Raff MJ. Fourth
International Symposiumon Legionella. Orlando, FL, January 1992.
Treatment of Clinical Specimens Containing
Mycobacterium tuberculosis by Sonication
to Remove DNA for the Polymerase Chain Reaction. Buck G, O'Hara LC &
Summersgill JT. 92nd GeneralMeeting, American Society for Microbiology, New
Orleans, LA, May 1992.
Killing of
Legionella pneumophila by nitric oxide in interferon-activated macrophages.
Summersgill JT, Sahney N, Miller R & Ramirez JA. 29th Annual Meeting, Society for
Leukocyte Biology, Charleston, SC, December, 1992.
Polymerase chain reaction (PCR) for diagnosis of pneumonia caused by
Mycoplasma
pneumoniae.Buck G,
Summersgill JT, Sahney N & Ramirez JA. 93rd General
Meeting, American Society for Microbiology, Atlanta, GA, May 1993.
Polymerase chain reaction compared with direct fluorescent antibody and culture for the
detection of
Legionella pneumophila in bronchoalveolar lavage fluid.
Summersgill JT,
Sahney N, Greenburg L, Miller R, Buck G & Ramirez JA. 18th International Congress of
Chemotherapy, Stockholm, Sweden, June 1993.
Comparative Bactericidal Activity of Ticarcillin/clavulanic acid and Erythromycin Against
Intracellular
Legionella pneumophila. Ramirez J, Sahney N,
Summersgill J, Miller R.
18th International Congress of Chemotherapy. Stockholm, Sweden. June, 1993.
Inhibition of
Chlamydia pneumoniae replication in HEp2 cells by gamma interferon. N
Sahney, J. Ramirez, L Greenburg, R Miller and
J Summersgill. 94th General Meeting,
American Society for Microbiology, Las Vegas, NV, May 1994.
Chlamydia pneumoniae is capable of growing in smooth muscle cells of aortic artery
origin in tissue culture. C Gaydos,
J Summersgill, N Sahney, J Ramirez and TC
Quinn. 94th General Meeting, American Society for Microbiology, Las Vegas, NV,
May 1994.
Rapid diagnosis of Legionnaires disease: DNA amplification of throat swab specimens.
J Ramirez,N Sahney, C Ahkee, R Miller and
J Summersgill. 94th General Meeting,
American Society forMicrobiology, Las Vegas, NV, May 1994.
Detection of
Legionella pneumophila in an immunocompromised population with
pneumonia using the polymerase chain reaction.
J Summersgill, C Gaydos, T Quinn, C
Fowler and J. Ramirez.94th General Meeting, American Society for Microbiology, Las
Vegas, NV, May
Replication of
Chlamydia pneumoniae in human pulmonary artery endothelial cells.
J
Summersgill, E Schmidt, C Gaydos, N Sahney, T Quinn and J Ramirez. 94th General
Meeting, American Society for Microbiology, Las Vegas, NV, May 1994.
Activity of erythromycin, rifampin, ciprofloxacin and ofolxacin alone or in combination
against intracellular
Legionella pneumophila. J. Ramirez, R Miller, N Sahney and
J
Summersgill. 94th General Meeting, American Society for Microbiology, Las Vegas,
NV, May 1994.
Degradation and inactivation of human cytokines by
Legionella pneumophila protease. N
Sahney, J Ramirez,
J Summersgill and R Miller. 94th General Meeting, American
Society for Microbiology,Las Vegas, NV, May 1994.
Characterization of
Legionella pneumophila replication in human pulmonary and
umbilical endothelial cells. Y Zhang, L Powell, P Tse, DE Justus,
J Summersgill, J
Ramirez and R Miller. 94th General Meeting, Amer.Society for Microbiology, Las Vegas,
NV, May 1994.
Diagnosis of
Mycoplasma pneumoniae, Legionella pneumophila and
Chlamydia
pneumoniae lower respiratory tract infections using the polymerase chain reaction
(PCR) on a single throat swab specimen. J Ramirez, S Ahkee, A Tolentino and
J
Summersgill. 34th Interscience Conference on Antimicrobial Agents and
Chemotherapy, Orlando, FL, October 1994.
Replication of
Chlamydia pneumoniae in human endothelial cells of various origon.
JT
Summersgill, CA Gaydos, EA Schmidt, NN Sahney, TC Quinn and JA Ramirez. 8th
International Symposium on Human Chlamydial Infections. Chantilly, France June
1994.
Growth characteristics of
Chlamydia pneumoniae in macrophages and endothelial cells.
CA Gaydos,
JT Summersgill, NN Sahney, JA Ramirez and TC Quinn. 8th International
Symposium on Human Chlamydial Infections. Chantilly, France June 1994.
Activity of erythromycin, rifampin, ciprofloxacin and ofloxacin alone or in combination
against
Legionella pneumophila Rameriz, J. R. Miller, N. Sahney, and
J. Summersgill. 1994. Abst. Ann. Meet. Am. Soc. Microbiol., A-31, p. 6.
Degradation and inactivation of human cytokines by
Legionella pneumophila
protease.Sahney, N., J. Ramirez,
J. Summersgill, and R. Miller. 1994. Abst. Ann.
Meet. Am. Soc. Microbiol., B-362, p. 93.
Inhibition of
Chlamydia pneumoniae replication in Hep2 cells by interferon-Sahney, N. J.
Ramirez, L. Greenberg, R. Miller, and
J. Summersgill. Soc. Microbiol., D-41, p 103.
Rapid diagnosis of Legionnaires disease: DNA amplification of throat swab specimens
Ramirez, J., N. Sahney, C. Ahkee, R. Miller, and
J. Summersgill. 1994. ., Abst. Ann.
Meet. Am. Soc. Microbiol., C-18, p. 493.
Signals required to activate actin in the phagocytic uptake of
Legionella pneumophila into human monocytes.Coxon, P.Y.,
J.T. Summersgill, J.A. Rameriz, and R.D. Miller.
1996. Abstr. Ann. Mtg. Am. Soc. Microbiol., B-161, p. 182.
Phosphprylation signals required for actin polymerization in the phagocytic uptake of
Legionella pneumophila into human monocytes.Coxon, P.Y.,
J.T. Summersgill, J.A
Ramirez, and R. D. Miller. 1996. Abstr. 2nd Interntl. Cong. Phagocytes: Biol. And Clin.
Aspects (Pavia, Italy), Eur. J. Haemotol. Suppl. 59, vol 57, Abstr# AP 21, p. 6
Comparative of laboratory diagnostic methods for
Mycoplasma pneumoniae in
HIV-positive and HIV-negative patients with community acquired pneumonia. LM
Mundy, CA Gaydos,
JT Summersgill, JA Ramirez, P Auwaerter, N Ford, L Duffy, G
Cassell, P Charache, RD Moore, JG Bartlett and TC Quinn. 95th General Meeting,
American Society for Microbiology, Washington, DC, May 1995.
Isolation of
Chlamydia pneumoniae from the coronary artery of a patient with coronary
atherosclerosis. JA Ramirez, S Ahkee, CA Gaydos, TC Quinn, MR Hammerschlag, PM
Roblin, CC Kuo, JT Grayston, LA Campbell, DL Patton, D Dean, J Schachter &
JT
Summersgill. 35th Interscience Conference on Antimicrobial Agents and
Chemotherapy, San Francisco, CA, September 1995.
Chlamydia pneumoniae stimulates secretion of chemokines and adhesion molecules in
human endothelial cells. Molestina, R., R.D. Miller,
J.T. Summersgill, and J.A. Ramirez.
1996. Abst. Ann. Mtg. Am. Soc. Microbiol., D-14, p. 243.
Virulent and avirulent
Legionella pneumophila induce similar phosphorylation signals
during phagocytic uptake into human monocytes. Tse-Coxon, P.Y.,
J.T. Summersgill,
J.A. Ramirez, and R.D. Miller. 1997Abst. Ann. Mtg. Am. Soc. Microbiol., B-146, p. 53.
Use of heteroduplex analysis of the 5S rRNA gene for classification of
Legionella species from PCR positive patient samples. Pinar, A., S. Ahkee, R.D. Miller, J. Ramirez,
and
J.T. Summersgill. 1997. Abst. Ann. Mtg. Am. Soc. Microbiol., B-147, p. 53.
Restriction of
Chlamydia pneumoniae growth in Hep-2 cells is mediated by induction of
indoamine-2,3-dioxygenase. Mehta, S.J., R.D. Miller, J.A. Ramirez, and
J.T.
Summersgill. 1997. Abst. Ann. Mtg. Am. Soc. Microbiol., D-16, p. 210.
Chlamydia pneumoniae promotes the migration of phagocytes across human endothelial
monolayers.Molestina, R.E., R.D. Miller,
J.T. Summersgill, and J.A. Ramirez. 1997.
Abst. Ann. Mtg. Am. Soc. Microbiol., D-17, p. 210.
Diagnosis of Legionnaires Disease: PCR amplification of the 5S rRNA of
Legionella in
urine and serum samples. Ramirez J, Ahkee S, Kitay M, Miller R,
Summersgill J.
Annual Infectious Diseases Society of America Meeting. San Francisco, CA.Sept 13-16,
Legionnaires Disease Acquired from a Malfunctioning Automobile Air Conditioner.
Ramirez J, Ahkee S, Kitay M, Miller R, Pinar A,
Summersgill J. Annual Infectious
Diseases Society of America Meeting. San Francisco, CA. September 13-16, 1997.
Stimulation of neutrophil and monocyte transendothelial migration by different isolates of
Chlamydia pneumoniae. Molestina, R.E., Miller, R.D.,
Summersgill, J.T., and Ramirez,
J.A. 1998. Proc. Ninth Intl. Symp. on Human Chlamydial Infection. Napa, CA, p. 419.
Migration of human monocytes through
Chlamydia pneumoniae-infected endothelial
cells: effects of roxithromycin. Uriate, S.M., R.E. Molestina, R.D. Miller, J.A. Ramirez,
and
J.T. Summersgill. 1999. Abst. Intersc. Conf. Antimicrob. Agents Chemother.,
#981, p. 669.
Expression of monocyte chemotactic protein-1 mRNA in human endothelial cells
infected with
Chlamydia pneumoniae. Molestina, R.E.,
J.T. Summersgill, R.D. Miller,
and J.A. Ramirez. 1999. Abst. Ann. Mtg. Am. Soc. Microbiol., D/B-78, p.224.
Inhibition of
Chlamydia pneumoniae replication in IFN-gamma-stimulated aortic smooth
muscle cells. Pantoja, L.G., R.D. Miller,
J.T. Summersgill, and J.A. Ramirez. 2000.
Abst. Ann. Mtg. Am. Soc. Microbiol., D-78, p. 243.
Etiology in Community-Acquired Pneumonia (CAP): Incidence of Combined Atypical and
Typical Pathogens. Ramirez, JA, G Cohen and
JT Summersgill. Annual Infectious
Diseases Society of America Meeting. New Orleans, LA 2000.
Atypical pathogens causing community-acquired pneumonia (CAP): presumptive
vs.definitive etiology. Ramirez, JA, G Cohen and
JT Summersgill. 2000. Abst. Intersc.
Conf. Antimicrob. Agents Chemother. New Orleans, LA 2000.
Rapid detection of
Mycoplasma pneumoniae from clinical specimens by transcription-
mediated amplification. M Cunningham, P Stull, K Clark-Dickey, W Weisburg and
JT
Summersgill. 2000. Abst. Intersc. Conf. Antimicrob. Agents Chemother.
Identification of proteins in Chlamydia pneumoniae elementary bodies by proteomic
analysis. R.E. Molestina, J.B. Klein, W.H. Peirce, J. Cai, R.D. Miller, J.A. Ramirez, and
J.T. Summersgill. 2001. Abst. Ann. Mtg. Am. Soc. Microbiol., D-144, p. 118.
Characterization of atypical
Chlamydia pneumoniae inclusions in HEp-2 cells treated
with interferon-gamma. 2001. Pantoja, L.G., R.D. Miller, J.A. Ramirez, R.E. Molestina
and
J.T. Summersgill. 2001. Abst. Ann. Mtg. Am. Soc. Microbiol., D-198, p. 180.
Uriarte, SM, Molestina, RE, R FernandezBotranRD Miller, JG Bernabo, A Farinati, K
EIguchi, JA Ramirez and
JT Summersgill. 2002. Effects of Macrolide and
Fluoroquinolone Antibiotics on the Expression of Monocyte Chemotactic Protein 1
mRNA and on the Levels of Soluble Intercellular Adhesion Molecule 1 in Endothelial
Cells Stimulated with Tumor Necrosis Factor-. Annual Meeting Infectious Diseases
Society of America, Chicago, IL, October 2002.
Proteomic analysis of persistent
Chlamydia pneumoniae in HEp2 Cells. Molestina, RE,
RD Miller, JB Klein, WB Pierce, JA Ramirez and
JT Summersgill. 10th Int'l Symp.
Human Chlamydial Diseases, Antalya, Turkey, June 2002.
Uriarte, SM, Molestina, RE, RD Miller, JA Ramirez and
JT Summersgill. Effect of
quinolone antibiotics on the migration of human phagocytes through
Chlamydia
pneumoniae-Infected and Tumor Necrosis Factor-α-stimulated endothelial monolayers.
10th Int'l Symp. Human Chlamydial Diseases, Antalya, Turkey, June 2002.
Muhkopadhyay, S, GB Harding, RD Miller and
JT Summersgill. Proteomic analysis of
Chlamydia pneumoniae grown under Normal and IFN-induced persistent Conditions.
Annual Meeting of the American Society for Microbiolgy, Washington DC, May 2003
Harding, GB, S Muhkopadhyay, RD Miller and
JT Summersgill. Improved method for
culturing and harvesting elementary bodies of
Chlamydia pneumoniae Annual Meeting
of the American Society for Microbiolgy, Washington DC, May 2003.
Comparative Proteomic and Transcriptomic Analysis of Interferon-Gamma Mediated
Persistence in
Chlamydia pneumoniae. S Mukhopadhyay1, D Good3, AClark1, ED
Sullivan1, R Hogan3, A Polkinghorne3, S Mathews3, RD Miller2, P Timms3 and
JT.
Summersgill. Annual Meeting of the American Society for Microbiolgy,New Orleans,
May 2004.
Proteomic Analysis of Persistent
Chlamydia pneumoniae in HEp2 Cells Induced
by Interferon Gamma and Other Cytokines. S Mukhopadhyay, E Sullivan, AP Clark,
Sarah A. Mathews, David Good, Peter Timms, Richard D. Miller and
J T Summersgill. 5th European Meeting on Chlamydial Biology. Budapest, Hungary, August 2004.
Community-acquired pneumonia due to atypical pathogens: a worldwide comparison of
the incidence and initial empiric therapy. Arnold F,
Summersgill J, Blasi F, File T,
Fernandez P, Porras J, Feldman C and Ramirez J.
Proceedings of the ATS 2005;2:A46.
Incidence and empiric therapy for atypical pathogens of community-acquired
pneumonia: An international perspective. Arnold F,
Summergill J, Cohen MG, and
Ramirez J.
Final Program and Abstracts of the Annual Meeting of IDSA 2004:423.
Proteomic analysis of
Chlamydia pneumoniae grown under normal and IFN-induced persistenct conditions. Sanghamitra Mukhopadhyay, George B. Harding, Richard D. Miller, and James T. Summersgill. Chlamydia Basic Research Society Meeting, Indianapolis, IN, April 2005
Comparative proteomic analysis by SELDI TOF-MS and 2D PAGE of
Chlamydia
pneumoniae persistence induced by Interferon-Gamma. Sanghamitra Mukhopadhyay,
Saeed A. Jortani, Roland Valdes Jr., Christine Q. Simmons, Erin D. Sullivan, Richard D.
Miller and
JT Summersgill. Annual Meeting of the American Society for
Microbiolgy,Atlanta, GA, May 2005.
Transcription mediate amplification assay for detection of
Legionella pneumophila in
samples from patients with community-acquired pneumonia. MK Hudspeth, K Clark-
Dickey, EM Marlowe, LG Schindler, K Campbell and
JT Summersgill. International
Legionella Conference, Chicago, IL, September 2005.
Development and Evaluation of Cepheid’s Analyte-Specific, Real-Time PCR Reagents
(ASR) for the Detection of
Mycoplasma pneumoniae in Patients with Documented
Community-Acquired Pneumonia (CAP).
JT Summersgill, Laura G. Schindler, Karen
Campbell and JP Zhang. Annual Meeting of the Association of Molecular Pathology,
Scottsdale, AZ, November 2005.
Evaluation of the Focus Diagnostics KINEDx Atypical Pneumonia Detection Kit for
real-time multiplex PCR detection of atypical bacterial pathogens from respiratory
specimens. Annual Meeting of the Association of Molecular Pathology, Los Angeles,
Indeterminate Results of the QuantiFERON®TB Gold (QFT) in Hospitalized
Patients at Risk for MTB Infection/Disease
. JT Summersgill, L. Schindler, K. Campbell
& J. Ramirez. European Respiratory Society Meeting, Berlin, Germany, October 2008.
Evidence for persistent
Chlamydia pneumoniae infection in coronary atheroma from
patients undergoing cardiac transplantation
. N Borel, P Peyrani, JA Ramirez, A
Pospischil &
JT Summersgill. Annual Meeting of IDSA, Philadelphia, November 2009.
Invited Presentations: "NCCLS Standards for Susceptibility Testing of Fastidious Bacteria." Kentucky State Society for
Medical Technology annual meeting. Louisville, KY. April, 1991.
"Laboratory Diagnosis of
Legionella Infections." Tri-County Clinical Microbiology Association
Meeting. Southfield, MI. November, 1993.
"Newer Methodologies of Diagnosis of Community Acquired Pneumonia Including PCR." 20th
International Congress of Chemotherapy, Sydney, Austraila, June 1997.
"Diagnostic Work-up for Patients with Community-Acquired Pneumonia". Infectious
Diseases:Update for the Practicing Physician. Southfield, MI. August, 1998.
"Rapid Diagnostic Methods in Community-Acquired Infections." Annual Congress of the
European Respiratory Society. Geneva, Switzerland. September, 1998
"Molecular Methods for Detection of Atypical Pneumonia Agents" 1st Turkish Microbiology
Association Conference on Molecular Detection. Cappadocia, Turkey, April 2000.
"Potential Role for
Chlamydia pneumoniae in Atherogenesis" Stratton VAMC, Albany, NY,
February 2001.
"Role for
Chlamydia pneumoniae Persistence in Chronic Disease". University of South
Alabama, Mobile, AL, January 2003.
"Role for
Chlamydia pneumoniae Persistence in Chronic Disease". Konstanz University,
Konstanz, Germany, June 2005.
"Laboratory Diagnosis of Aypical Pneumonia", Southern California Knowledge Symposium,
BioMereiux, Inc., Los Angeles, CA, September 2006.
Research Support:
Past
1986- Committee for Academic Excellence, University of Louisville.
"Interactions of virulent and avirulent
Legionella pneumophila with human neutrophils"
1990- American Lung Association of Kentucky "Effects of
Legionella pneumophila on human
1990- Alliant Community Trust Fund (Co-Investigator)
"Improved diagnosis of infectious and genetic diseases by gene amplification"
1991- American Lung Association of Kentucky
"Effects of
Legionella pneumophila on human phagocyte activation"
1992- Alliant Community Trust Fund (Co-Investigator)
"Diganosis of
Mycoplasma pneumoniae Infections by the polymerase chain reaction."
1993- Alliant Community Trust Fund (Co-Investigator)
"Diagnosis and prevalence of
Chlamydia pneumoniae Infections"
1994- Alliant Community Trust Fund (Co-Investigator)
"Replication of
Chlamydia species in cells associated with atherosclerosis"
1994- Jewish Hospital Heart and Lung Institute, Louisville, Ky
"Secretion of chemoattractants and adhesion molecules by human endothelial cells infected with
Chlamydia pneumoniae"
1994- Jewish Hospital Heart and Lung Institute, Louisville, Ky
"Is
Chlamydia pneumoniae present in the coronary atheroma of patients with coronary artery disease in Kentucky?"
1994- American Heart Association of Kentucky
"Interactions of
Chlamydia pneumoniae with cells associated with atherosclerosis"
1995- Jewish Hospital Heart and Lung Institute, Louisville, Ky
"Presence of
Chlamydia pneumoniae in the coronary atheroma of patients with coronary artery disease"
12/1/01 - 11/30/05 - NHLBI, National Institutes of Health
"Proteomic Analysis of Persistent
Chlamydia pneumoniae"
7/1/02 - 6/30/04 NIH-NIAID (R21 AI51255-01)
"Gene Expression of Persistent
Chlamydia pneumoniae"
7/1/07-6/30/09 - American Heart Association
“Persistent
Chlamydia pneumoniae in Human Coronary Atheroma”
Source: http://www.iduofl.us/documents/cvs/JamesSummersgill.pdf
EL INFRASCRITO SECRETARIO MUNICIPAL, DEL MUNICIPALIDAD DE SAN MIGUEL SIGUILA, DEPARTAMENTO DE QUETZALTENANGO. CERTIFICA: Que para el efecto tuvo a la vista el libro de actas tomo siete de sesiones municipales, autorizada por la Contraloría General de Cuentas departamental, en donde se encuentra el acta, copiada su parte conducente, que literalmente dice: ACTA No. 13/2009. Sesión Públi
ASCO: Dr. Martine Piccart, in Karnofsky Lecture, Outlines Vision for the Empowering of Academic Research By Susan Beck | June 10, 2013Executive Editor, ONCOLOGY CHICAGO—The David A. Karnofsky Memorial Award, ASCO’s highest scientific honor, went this year toDr. Martine J. Piccart, who is internationally recognized for her unflagging dedication and innovativeapproaches to the developme