MATERIAL SAFETY DATA SHEET 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product name(s) Recommended uses and restrictions Raw, commingled bovine milk must be used. 24 hour Emergency Phone # CHEMTREC 1-800-424-9300 2. HAZARDS IDENTIFICATION According to Regulation (EC) No1272/2008 SNAP Device This substance is not classified as dangerous. Reagent Pellet Eye Irritation, Category 2 Pictogram Contains ProClin 150. May produce an allergic reaction. cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue If eye irritation persists: Get medical advice/attention. According to European Directive 67/548/EEC as amended. SNAP Device This substance is not classified as dangerous. Reagent Pellet Hazard In case of contact with eyes, rinse immediately with plenty of water and MATERIAL SAFETY DATA SHEET 3. COMPOSITION/INFORMATION ON INGREDIENTS 4. FIRST AID MEASURES IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Wash with plenty of soap and water. If skin irritation occurs: Get medical advice/attention. Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. 5. FIRE FIGHTING MEASURES Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for firefighters Wear self contained breathing apparatus for firefighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Use personal protective equipment as required. Environmental precautions Avoid release to the environment. Methods and materials for containment and cleaning up Wipe up with absorbent material. 7. HANDLING AND STORAGE Precautions for safe handling Use personal protective equipment as required. Wash thoroughly after handling. Conditions for safe storage Store in a well-ventilated place. Keep container tightly closed. 8. EXPOSURE CONTROLS / PERSONNAL PROTECTION Personal protective equipment Respiratory protection In case of inadequate ventilation, wear respiratory protection. Hand protection MATERIAL SAFETY DATA SHEET Wash thoroughly after handling. Do not get in eyes, on skin, or on clothing. Control parameters 9. PHYSICAL AND CHEMICAL PROPERTIES SNAP 10. STABILITY AND REACTIVITY Chemical stability Stable under recommended storage conditions. 11. TOXICOLOGICAL INFORMATION Dimethyl sulfoxide LD50 Oral - rat - 14500 mg/kg LC50 Inhalation - rat - 4 h - 40250 ppm LD50 Dermal - rabbit - > 5000 mg/kg Skin - rabbit - Mild skin irritation - 24 h Serious eye damage/eye irritation Eyes - rabbit - Mild eye irritation Respiratory or skin sensitization Genotoxicity in vitro - mouse – lymphocyte Cytogenetic analysis Genotoxicity in vitro - mouse – lymphocyte Mutation in mammalian somatic cells. IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. MATERIAL SAFETY DATA SHEET Carcinogenicity - rat – Oral Tumorigenic: Equivocal tumorigenic agent by RTECS criteria. Skin and Appendages: Other: Tumors. Reproductive toxicity - mouse - Oral Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea). Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific Developmental Abnormalities: Musculoskeletal system. Specific Target Organ Toxicity –Single Exposure Specific Target Organ Toxicity –Repeated ProClin 150 Serious eye damage/eye irritation Eyes - rabbit – Corrosive to eyes Respiratory or skin sensitization guinea pig - May cause sensitization by skin contact IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC Specific Target Organ Toxicity –Single Inhalation - May cause respiratory irritation. Exposure Specific Target Organ Toxicity –Repeated 12. ECOLOGICAL INFORMATION Dimethyl sulfoxide LC50 - Pimephales promelas (fathead minnow) - 34000 mg/l - 96 h LC50 - Oncorhynchus mykiss (rainbow trout) - 35000 mg/l - 96 h Toxicity to daphnia and other aquatic EC50 - Daphnia pulex (Water flea) - 27500 mg/l EC50 - Lepomis macrochirus (Bluegill) - > 400.000 mg/l - 96 h ProClin 150 Toxicity to daphnia and other aquatic invertebrates. Persistence and degradability MATERIAL SAFETY DATA SHEET 13. DISPOSAL CONSIDERATIONS Dispose of contents in accordance with local/regional/national/international regulations. 14. TRANSPORT INFORMATION DOT (US) 15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Obstetrics & Gynecology 830 Oak Street, Suite 201W 199 Reedsdale Road Brockton, MA 02301 Milton, MA 02186 (508) 583-4961 (617) 696-0695 Fax (508) 583-4732 (617) 696-2216 [email protected] METFORMIN What Is Metformin? Metformin (Glucophage) is a drug (an oral biguanide antihyperglycemic agent) approved for the treatment of adult-onset (type 2) diabetes mellitus. It
Components and auxiliary traits of dairy cow fertility: The genetic view Hermann H. Swalve Institute of Agricultural and Nutritional Sciences Martin-Luther University Halle-Wittenberg Adam-Kuckhoff-Str. 35. 06118 Halle (Saale), Germany Types of fertility In dairy farming and breeding, fertility besides milk production is a trait of utmost importance. When talking about fertility,