All_oral_presentations.xls

2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
08:00 Antibacterials - Clinical Aspects -
Erythromycin: Magic Bullet for Sore Throat and its Consequences in Children Randomized controlled clinical trial of day-care based and hospitalized management of severe childhood pneumonia by injection ceftriaxone in Dhaka, Bangladesh Management of deep space neck abscesses. Five year experience Alveolar echinococcosis: The impact of chemotherapy and surgery on survival 08:00 Antineoplastic agents - New targets
Breast and Prostate tumor cell destruction by Salmonella with preferential targeting of & compounds - Part I
TARGETING MUTATED JANUS KINASES IN MYELOPROLIFERATIVE NEOPLASMS DRUG DISCOVERY Selective stimulation of human natural killer cells proliferation by novel fucosylated acidic glycan drugs: possible therapeutic use for treating cancer and viral/retroviral infections 08:00 Antibacterials - Discovery - New
The Discovery of New Scaffold Antibacterial Agents methods of chemical significance
Neomycin, Kanamycin and Pyranmycin: Synthesis, Antibacterial Activity and New Applications Synthesis of Some New 1,3,4-Thiadiazol-2-ylmethyl-1,2,4-Triazole Derivatives and Investigation of Their Antimicrobial Activities Synthesis, in silico ADME-Tox study and Antimicrobial Evaluation of some small Molecules AN ENTRY TO CLAVAMS FROM CHIRAL VINYL ETHERS AND CHLOROSULFONYL ISOCYANATE A Simple Microwave-assisted Synthesis of Sulfonamides directly from Sulfonic Acids 08:00 Antibacterials - New antibiotic and
Chemical Postevolution of Antibacterial Natural Products antineoplastic compounds from
nature - Part I
Natural Products (NP) - Microbial Metabolites (MM) - Antibiotics (AB): History, Facts and Problems, Where Now ? Dioxin like compounds for anti-infective agents of know as its degrading enzyme from Geobacillus midousuji thermophile Disinfectant effect of Garcinia kola extract on Staph. Aureus Drug Potential of Nigerian MedicinE Related Plants: A SURVEY 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
08:00 Antibacterials - New compounds and
Pulmonary Drug Delivery System for Efficient Treatment of Tuberculosis mechanisms - focusing on
tuberculosis and delivery
Mode of Action of a Naphthoquinone on Tuberculosis Discovery of a Novel Anti-MRSA Agent TAK-599 (Ceftaroline Fosamil): An N-Phosphono Water-Soluble Prodrug for Intravenous Injection Interactions of liposomal vesicles with bacterial cells and antimicrobial activity of liposomal antibiotics A diarylquinoline targeting the energy supply of M. tuberculosis has the Potential to change the TB treatment paradigm 08:00 Antibacterials - Resistance,
CIPROFLOXACIN RESISTANCE PROFILE IN KLEBSIELLA PNEUMONIAE surveillance, and guidelines
ISOLATES DURING 2002-2007 IN PAEDIATRIC SEPTICAEMIC CASES OF A TERTIARY CARE HOSPITAL IN INDIA Antimicrobial Prophylaxis in Surgery and Emergence of Super bugs: Dilemma in Developing Countries Bacterial tetracycline resistance: prevalence, evolution and dissemination of genes Dentistry and Antibiotic Resistance: The Need to Set Guidelines and Improve Prescribing Practices Molecular investigation of drug resistant Neisseria gonorrhoeae clinical isolates Clinical Importance of Antimicrobial Resistance 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
08:00 Antineoplastic agents -
Molecular guidance systems for nuclear-tipped magic bullets?: Clinical experiences in Effectiveness and resistance in
thyroid cancer treatment using recombinant TSH to activate the target patients - Part I
Multidrug Resistance Inhibition in Acute Myeloblastic leukemia by Antisense Oligonucleotide Verotoxin (Shiga toxin) binding to its receptor glycolipid, globotriaosyl ceramide, provides a new antineoplastic tool and physiologically-based approaches to tumour cell drug resistance Experimental Evidence for Killing the Resistant Cells and Raising the Efficacy of Cytostatics by a New Anticancer Drug Candidate (Culevit Infusion) Developed on the Basis of the Passive Antitumor Defence System The urokinase system is a natural inducer of cancer cell drug resistance SAFE AND EFFECTIVE DELIVERY OF PACLITAXEL THROUGH AMPHIPHILIC BETA-CYCLODEXTRIN NANOPARTICLES 08:00 Antineoplastic agents - Factors
Development of SERCA Inhibitors Targeted towards Prostate Cancer Cells.
affecting cancer and cancer
chemotherapy - Part I
The G-rich promoter and G-rich coding sequence of basic fibroblast growth factor are the targets of thalidomide in glioma Monitor of Chemosensitivity by Bcl-2 Transcript Kinetics in Acute Myeloid Leukemias PROTON TRANSPORT INHIBITORS (PTI) AS SELECTIVE ANTICANCER AGENTS The Many Lives of Hsp10: From Early Pregnancy Factor to Potential Antitumoral Agent. New Proteomic Data and a Review of the Literature Focusing on Its Immunologic Properties 10:15 Antineoplastic agents - Tyrosine
Transcriptional Changes Induced by Imatinib and Nilotinib in the Chronic Myelogenous Kinase Inhibitors - Part I
Receptor Tyrosine Kinases as Therapeutic Targets in Malignant Glioma, present status and application in China The critical role of IL-15 trans-presentation in the antitumor effects mediated by the combination therapy with Imatinib and IL-2 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
10:15 Antivirals - Mechanisms and
Antiviral effect of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil development of antivirals - Part I
fumarate, administered orally alone and in combination, to woodchucks with chronic woodchuck hepatitis virus infection.
The Potential of Oxoglaucine, a New Antiviral Compound, to Inhibit Enterovirus Replication When Applied Alone or in Combination Nitric oxide and zidovudine potentiate oxidative response of stimulated macrophages Non-steroidal Anti-inflammatory Drugs; a Potential New Way to Treat Human Cytomegalovirus (HCMV) Disease 10:15 Biomarkers and their applications
Success story of the first regulatory approval of safety biomarkers, Part I: From identification to biological qualification Noninvasively Evaluation on Human Stress Using Salivary Biomarker Strategic Role of Prednisolone, Vincristine and Asparaginase in Pediatric Leukemia as a Paradigm of Success in Oncology: Individualized Tumor Response Testing and Microarray Analysis Cell Hydration as a Universal and Extra-sensitive Biomarker for Determination of the Functional State of the Organism Pivotal Evaluation of the Accuracy of a Diagnostic Biomarker: the PRoBE Study Design Methemoglobin as the Biomarker of Environmental Oxidants and Precursor of Adverse Effects of Oxidative Sress on Mother and Fetus - Reasons for its Early Detection and Therapy Inhibition of experimental Sjögren’s syndrome through immunization with Hsp 60kDa and its peptide aa437-460 - predicting treatment efficacy using multi-plex biomarker profiling 10:15 Blood-brain barrier - History and
The blood-brain barrier and its magic transporters – a pharmacokinetic perspective on most recent finding - Part I
how to optimize drug delivery to the brain Circumventing the blood-brain-barrier. Soviet attempts during World War 2 10:15 Pharmaceutics - Drug delivery - Part
Cyclotides, ultrastable peptide frameworks for magic bullet drug delivery Optimize a therapeutic with NSAIDs: intelligent design for delivery systems Targeted delivery of cytotoxic drugs by means of protein vectors 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
10:15 Masspektrometry in pharmaceutics
Masspektrometry in pharmaceutics and biochemistry and biochemistry
10:15 Treatment of diseases with
Novel Generation of Antivirotics: Combination of Antimetabolic and Immunostimulatory involvement of the immune system -
High-dose cyclophosphamide is active in immune-mediated illnesses Expression of Fas on human T lymphocytes under stimulation with Borrelia burgdorferi sensu lato.
Prevention of Inflammatory Leukocyte Adhesions for Treatments in Acute Sepsis Condition by Anti-CD18 sFv Single-Chain Antibody Genetic immunization for the induction of humoral and cellular immune responses; a water in oil liposome-based in comparison with in vivo electroporation.
Rheumatoid arthritis, Proteus and “magic bullets” 10:15 Antibacterials - New and innovative
Perspective Chemotherapeutic Combination to Combat Flu approaches to discover and develop
antimicrobials - Part I
One target, two bullets : from erythromycin to telithromycin, what makes the difference ? The use of DNA based therapies to restore clinical efficacy of antibiotics 10:15 Antibacterials - Resistance in gram
Magic activity of beta-lactam antibiotics against intracellular Methicillin-Resistant S. positives
Antibiotic Resistance Of Psychrotrophs Spoiling Raw Milk Susceptibilities of rickettsiae to antimicrobials Application of Saffron and Its Ingredients as a Known Pharmacological Herb from Ancient Times and the Mechanisms of Their Action 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
10:15 Antibacterials - Molecular
Prediction of species-specific targets for the development of STAMPs based on microbiology
analyses of bacterial species-level supragenomes Development of species-specific STAMPs (specific targeted antimicrobial peptide) that target and kill only Streptococcus pneumoniae within a polymicrobial community Augmenting endogenous nitric oxide production to kill multiresistant P. aeruginosa in cystic fibrosis lung disease.
Can We Make Eucaryotic Cells Resistant to Antibiotics? Correlation between Multidrug Resistance-associated Protein (Mrp) Efflux Pump Expression and Fluoroquinolones Accumulation in J774 Macrophages The unexpected hiddeen face of the Cephalosporin Antibiotic Ceftazidime: From biological to chemical and physical activities against oxidant species produced by phagocytes 10:15 Antineoplastic agents - New
Selenium Derivatives as Cancer Preventive Agents strategies and new compounds- Part
I
Heterocyclic hydrazones induce radical formation and dissipation of mitochondrial membrane potential Retargeting anticancer drugs to drug resistant cancers by using polymer Biotransport technology. Clinical proof of the concept 10:15 Treatment of severe diseases
Low-dose steroids in critically ill patients: Who should be treated and when? Inhaled H2S for suspended animation in anesthetized and ventilated mice H2S-induced suspended animation during porcine aortic occlusion-induced ischemia reperfusion injury Red blood cell omega-3 fatty acids and the risk of ventricular arrhythmias in patients with heart failure 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
13:15 Antineoplastic agents - Compounds
The High Cytotoxicity of Cisplatin Nanocapsules in Ovarian Carcinoma Cells Depends and approaches - Part I
on Uptake by Caveolae-Mediated Endocytosis Experimental approach for growth inhibition of human malignancies by the highly efficient anti-tumor peptide delivery system Enigmatic eosinophil as magic bullet: Eosinophil-induced prognosis improvement of solid tumors could be enabled by their vesicle-mediated barrier permeability induction Vitamin A and D Derivatives; Potential MAGIC BULLETS with Antithrombotic and Antineoplastic Applications The potential of orally presented mistletoe lectins in cancer therapy Green tea polyphenol, EGCG, prevents tumor lung metastasis in mice through enhancing anti-tumor immunity.
Anti?neoplastic properties of tea catechins are associated with pro?differentiation caspase 14 gene expression: implementation for novel therapies 13:15 Antineoplastic agents - Approaches
CYTOCHROME P450 DEPENDENT DRUG RESPONSE IN ONCOLOGY to optimize therapy - Part I
The Chemical Interaction of the Anticancer Drugs Irinotecan-HCl and Epirubicin-HCl in the Same Infusion Solution The differential dose-dependence for pro-angiogenic and cytotoxical effects of new anticancer plant agent within different nanocarrier formulations.
KIT-deficient mouse and KIT-targeted drug 13:15 Antiparasitic compounds -
[Approaches against Malaria - final title not yet available] Therapeutic approaches
Fasudil: the new ''magic bullet'' to thwart Malaria mortality? Plasmodium Heme Crystallization: Methylene Blue to the Quinolines Mediterranean spotted fever(MSF) in Oran (Algeria) 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
13:15 Pharmaceutics - Experimental and
computational approaches - Part I
ELECTROCHEMICAL BEHAVIOR OF FLAVONOIDS IN THE PRESENCE OF METAL IONS Fundamental Understanding on Interactions of Bisphosphonates with Bone (by Use of Different Techniques, Including Computational Modelling) 13:15 Antivirals - General issues and their
Differential roles of physiological and physicochemical parameters on low and variable solutions - Part I
bioavailability of Saquinavir- hurdles of effective drug treatment Possible Consequences of Transplacental Transfer of Viruses in Healthy Pregnants Elucidating Inhibitor-enzyme Interaction of Highly Potent Non-nucleoside Reverse Transcriptase Inhibitors Active Against Wild-type and Mutant HIV-1 Strains: Computer-aided Molecular Design Approaches HIV/AIDS and Malarial/Toxoplasmosis Co-Infections: a Magic Bullet Approach to Drug Development Bulletprooves to Abacavir-related Hypersensitivity Reaction in HIV-infected Population New neutralizing monoclonal antibodies from HIV-1 subtype C and CRF02_AG infected people 13:15 Blood brain barrier physiology and
5-HT2a antagonists as a new treatment for JCV-associated progressive multifocal diseases - Part I
Blood choline phospholipids as preferential sources of docosahexaenoic acid to the brain Hierarchy of Immune Responses behind the Blood-Brain-Barrier (BBB) in the Normal Brain: Implications for the development of CNS Diseases and Treatment Pathogenesis of Blood-Brain Barrier Breakdown Following Brain Injury: Windows for Therapeutic Intervention 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
13:15 Antineoplastic agents - New
The role of endothelial cell heterogeneity in the search for anti-angiogenic agents mechanisms & compounds - Part I
Antineoplastic effects of an aurora B kinase inhibitor against breast cancer Rituximab Maintenenance Therapy in CD20+ B-Cell Non-Hodgkin-Lymphoma – First results of a multicenter prospective randomised Phase II study Molecular mechanism of action and cellular consequences of the DNA minor groove alkylating agent S23906-1 13:15 CNS - Pharmacological options in
Discovery of novel non-cyclam polynitrogenated CXCR4 coreceptor inhibitors disease of the central nervous
system - Part I
The clinical role of the statins in surgical neurosciences Multiple mechanisms of action and pharmacological activities of valproate' Are the Substituted Phenethylamines Magic Bullets? Benefits and Harms of Amphetamines and Related Compounds Cholinesterase Inhibitors and NMDA Receptor Antagonists in Alzheimer's Disease and Pesticide Poisoning Structure and Functions of the ubiquitous TRPC Channels: Targets in need of magic bullets 13:15 Recombinant Proteins - a new class
Synergy between structural stability and DNA-binding controls the antibody production of Magic Bullets- Part I
in EPC/DOTAP/DOPE vesicles and DOTAP/DOPE lipoplexes Discovery of Malaria Vaccine Candidates – Application of the HT Cell-Free Protein Production System Born of the Study on Ricin Toxin The Impact of Inflammatory Responses on Taste Bud Cell Turnover and Function Wheat and barley for celiac patients by molecular silencing of the immunogenic endosperm proteins 13:15 Antibacterials - Adverse events and
Aminoglycosides as a paradigm of multidisciplinary approach to drug toxicity mechanisms of toxicity - Part I
Prevention of hepatotoxicity in patients undergoing anti tuberculosis treatment: A novel integrative approach.
2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
13:15 Vaccines - Development, production
Selection of Cell Culture Substrates for Human Viral Vaccines and manufacturing - Part I
Adjuvant Systems for vaccines targeting unmet needs: from concept to clinical evidence Recombinant virus-like particles and their application for vaccine development and diagnostics Inhibition of HIV-1 through an Innate Humoral Mechanism – a Potential for Vaccine Development Therapeutic Vaccination Followed By Antiretroviral Therapy Interruption (TI): Results From A Single Blind, Randomized, Controlled, Multicenter Phase II Study With An MVA-Nef Vaccine In HIV-1 Infected Patients Search for the Perfect Synthetic Isoprenoid Glycolipid Vaccine Adjuvant 13:15 Vaccines - Physiology and molecular 1112 Cassone
Cross-kingdom vaccines : dogma and heresy biology - Part I
Resolution of cancer and infection induced wounding is an essential factor in immune enhancement. The answers to why and how revealed.
Vaccines:The Magic wand of Indian Public Health?" 13:15 Antineoplastic agents - New
Oxidative stress in periodontal diseases and associated neoplasias: a role for promising mechanisms - Part I
Clusters of Free Radicals from Dihydroartemisinin Cure Several Parasitic and Viral Diseases. They Attack Cancers by Activating a Series of Apoptotic Pathways and by Causing Strong Angiogenesis Inhibition.
Depending on PKC-theta expression, the novel PKC activator PEP005 can either increase or decrease apoptosis of hemopoetic cells.
Inhibition of the Ras-Net (Elk-3) Pathway by a Novel Pyrazole that Affects Microtubules Design and Synthesis of Folate Targeted Chemotherapeutics 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
13:15 Pharmaceutics - Nanoparticles and
Magnetic nanoparticles for controlled delivery of methotrexate their latest developments - Part I
Chitosan-stealth polymeric nanoparticles for mucosal insulin delivery Biocompatible nanoparticles, carriers of the magic bullet.
G-Protein Coupled Receptors – New Portals for Nanoparticles in Cellular Drug Targeting? 13:15 Which role does PK/PD play in drug
Streamlining drug development using modeling and simulation development?
Bioequivalence - Still an Applied Science or already a Cookbook? Modeling and Simulation for Optimal Drug Development in Pediatric Populations 13:15 Biotechnology of drug delivery
Enhanced Potency of Antibodies using biologically active Peptides Systematic Discovery of Novel Multi-Target Therapeutics: Finding the New Magic Bullets Selective stimulation of human NK cells proliferation by novel compounds: possible therapeutic use for treating cancer and viral/retroviral infections Intracellular and organelle-specific drug delivery: The new frontier for Magic Bullets 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
15:30 Agents / diseases affecting the
The Immunosupressive Drugs- Cyclosporin A, FK506 and Rapamycin Modulate the immune system - Part I
Functional Expression of the Na+-Ca2+ Exchangers in an Isoform Specific Manner Polyclonal Rabbit Antiserum Against Porcine-SP-A Able to Detect Human SP-A Using Immunochemical Methods Electronic homeopathic preparations as potential Magic Bullet: Pilot study on biologic model Alpha 1 Antitrypsin (AAT) for the Treatment of Autoimmune Diseases New perspectives in the treatment of melanoma by a glycobiological approach: results in mouse experimental model.
Helicobacter cysteine-rich proteins A and -C, two novel signaling molecules form the family of Sel1-like repeat proteins involved in the modulation of pathogen/host interactions.
15:30 Anti-infectives - Approaches to
Staphylococci - from full susceptibility to almost full resistance combat resistance
Developing a magic bullet against P-glycoprotein-mediated drug resistance by exploiting mechanism 15:30 Antifungals - Pharmacokinetics and
Pharmacokinetics and Pharmacodynamics of Amphotericin B and its Lipid formulation issues
The pharmacokinetics of voriconazole in children MICROEMULSIONS OF AMPHOTERICIN B: A WAY TO CHANGE ITS PROFILE OF ACTIVITY AND TOXICITY.
15:30 Professional perspectives for health
Professional perspectives for health professionals: meeting a pharmaceutical professionals
The pharmacokinetics of voriconazole in children 15:30 Cardiovascular - Drugs acting on the
Increased repolarization reserve as a new anti-arrhythmic principle cardiovascular system - Part I
The Acute Effects of Statins in an Experimental Model of Renal Ischemia-Reperfusion Injury In search of the magic bullets: discovery of RN5 and its structural modifications for targeting selectively alfa1 adrenoceptors Effect of Insulin Resistance on In-Stent Restenosis after Coronary Stenting in Type 2 Diabetic Patients Effects of Small-volume Resuscitation Using Hyperosmolar Saline Colloid Solution on Regional Blood Flow and Ischemic Tissue Injury Levosimendan – More than an Inotropic Agent ? 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
15:30 CNS - Pharmacological options in
Effect of Valeriana officinalis extracts in [3H] Glutamate Binding disease of the central nervous
system - Part II
Interactions between cocaine, EAAT and NO 15:30 Clinical studies with agents of
Increase of fibrin network porosity and the consequent fibrinolysis as an anticoagulant different pharmacological activity -
L-tryptophan as a Research Compound and Therapeutic Agent Clinical Efficacy and Safety Evaluation of Roxithromycin in Rheumatoid Arthritis – An Open Label Study.
Sulfasalazine Revisited: A Multi-Targeted Magic Bullet LONG-TERM SEQUENTIAL DEFERIPRONE-DEFEROXAMINE VERSUS DEFERIPRONE MULTICENTER RANDOMISED CLINICAL TRIAL FOR THALASSEMIA MAJOR PATIENTS: DECREASE IN MORTALITY.
15:30 Antibacterials - New and innovative
Silencing Cell-Cell Communication: The New Bullets in Anti-Infectives approaches to discover and develop
antimicrobials - Part II
15:30 Nerve diseases, mechanisms, and
PROTECTIVE EFFECT OF DIMEBON ON THE TNF-a –INDUCED LIPID pathophysiology - Part I
MRI monitoring of blood brain barrier alterations in inflammatory lesions of Multiple Sclerosis: Tools to evaluate disease activity, efficacy of treatments and to develop new therapeutic strategies 15:30 Pharmaceutics - Discovery of drugs
The design of drugs which do not create resistance: folding inhibitors and mechanisms - Part I
Process Research on a Key Synthetic Intermediate of Clopidogrel Key Aspects for the Compilation and Enhancement of a Comprehensive Chemogenomics and Drug Discovery Compound Screening Collection 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
15:30 Cytochrome P450 - in vitro studies -
Using Chimeras with C-Terminal Tails NOSs for Probing of the Electron Traffic in Anti- and pro-oxidant actions of metalloporphyrins in mimicking SOD, peroxyredoxin, and cyt P450 Physico-Chemical Insights in Biological Conversions; the Role of H2O as driving Force in Cytochrome P450 catalysis 15:30 Antibacterials - Discovery - Peptide
Designing Peptidic Magic Bullets Against Bacteria antibiotics - Part I
Production of cystine rich peptides and protein in E. coli: hepcidin, the iron-regulating hormone. Lantibiotics: insight and foresight for new antimicrobials; Structure-function relationships, mode of action, molecular mechanisms of immunity (resistance), lantibiotic engineering 15:30 Antibacterials - Looking at the fate of
EFFECT OF FLUNIXIN ON ENROFLOXACIN CLEARANCE AND STEADY-STATE anti-infectives in- and outside the
body - Part I
Magic Bullets: Once Fired – How are They Recaptured? On the Metabolic Transformation and Environmental Fate of the Veterinary Fluoroquinolone Enrofloxacin Effect of gentamicin on serum digoxin level in patients with congestive heart failure Controlled Release Amoxicillin Therapy in Veterinary Medicine 15:30 Atherosclerosis, stroke & aging -
Modification of the Infarct Size Limiting Effects of Statins by Antiplatelet Drugs mechanisms and treatment - Part I
Intragraft Administration Of Abciximab And Verapamil Combined With Direct Stenting Prevents Slow-Flow And No-Reflow Phenomenon In Saphenous Vein Graft Percutaneous Coronary Intervention 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
15:30 Antidepressant drugs and their
New Features of Antidepressant Drugs - Modification of Histamine Kinetics mechanism of action Part I
Escitalopram-the first ASRI. A Magic Bullet in the treatment of depression and anxiety Photophysics, Photochemistry and induced-Photoallergy of Tricyclic Antidepressants 15:30 Antineoplastic agents - Effects of
well known anti-tumor agents and
drugs with other primary action -
Part I
Antitumor potency of angiotensin II receptor blocker for prostate cancer Cardioprotective Anthracycline PKC Activators for The Treatment of Drug-Resistant Tumors 17:30 Cardiovascular - Drugs acting on the
Systemic Immunosuppressive Therapy with Oral Sirolimus After Bare Metal Stent cardiovascular system - Part II
Implantation: The Missing Alternative in the Prevention of Coronary Restenosis After Percutaneous Coronary Interventions.
CARDIAC TAMPONADE SECONDARY TO SLINGSHOT METAL DART : A RETROSPECTIVE REVIEW OF CASES Structure Based Design of Second Generation PDE5 Inhibitors Pharmacokinetic-Pharmacodynamic modeling of calcium channel blockers in animal models of hypertension.
17:30 Antineoplastic agents -
Using Exercise as a Modality to Identify Therapeutic Molecules for Treatment & Effectiveness and resistance in
patients - Part II
Para-aminobenoic acid and a novel analog enhances the antitumor activity of ionizing radiation and chemotherapy drugs. Results from preclinical studies and a phase I study with stage IV melanoma patients.
Spectroscopic study on the interaction of the antitumoral drug emodin with bovine serum albumin: fluorescence, circular dichroism, SERS, SEF and stopped-flow techniques 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
17:30 Mechanisms of inflammation and
Cationic liposomes:how a magic bullet turns into an anti-inflammatory agent. anti-inflammatory agents - Part I
Brain•fs immune cells and anti-inflammatory effects of neuropeptides Magic Bullets for Joint Treatment. Why Doxycycline? Methotrexate in Dermatology through 50 Years 17:30 Physiology & Magic Bullets - Part I
Isoproterenol and Insulin: the Ying-Yang of regulation of Mg2+ homeostasis in mammalian cells Transcription of Major Histocompatibility Complex Class I (Kb) and Transporter Associated with Antigen Processing 1 and 2 genes is up-regulated with age 17:30 Analgesia & analgetic drugs - Part I
Levetiracetam in the treatment of neuropathic pain: evidence from cellular and behavioral pain models Under-treated painful condition may lead patients to opioid abuse 17:30 Drug transporters and delivery - Part 1217 Oosterhuis
Transporter Mediated Drug-Drug Interactions: Modulation of Drug Absorption by Predicting the Impact of Hepatic Transporters on the Pharmacokinetics of Statins in the Liver 17:30 Transporters of physiological
Na-Coupled Bicarbonate Transporters: Expression, Structure and Function compounds and drugs - Part I
Aminoglycoside Derivatives as Drug Transporters: Delivery Magic Bullets? Ca2+-signal transducing system from the endoplasmic reticulum to mitochondria involved in the caffeine-inducible ATP transport 17:30 Antibacterials - New mechanisms
Effect of antineoplastic agents on the surface properties of bacterial cells. and delivery strategies - Part I
The role of lipid rafts in host-pathogen interactions: Involvement of lactosylceramide-enriched lipid rafts in innate immunity and mycobacterial infection Liposomal Rifabutin: an efficient drug delivery system for the treatment of mycobacterial infections 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
17:30 Clinical studies with agents of
25-Years of Sight Saving by Preventing Postoperative Scarring with Local Use of different pharmacological activity -
Preliminary results of the Semmelweis Budapest Mastocytosis Center Vitamin C in intravenous nutritive solution: double-edge effect for premature newborn infants 17:30 Antineoplastic agents - Delivering a
New multifunctional pharmacophores and biocompatible nanocomposites for targeting Magic Bullet to its target(s) - Part I
Efficient cancer therapy by use of neovascular-targeted liposomes.
Chemoembolisation Using Drug Eluting Beads: Magic Bullets Targeted by Arterial Guidance.
17:30 Antineoplastic agents - Personalized 10001 Fuhr
Application of pharmacokinetics of individualize antineoplastic therapy therapy - Part I
Personalized Prevention of Colorectal Neoplasia: High Magnesium and Low Calcium among People with a Functional Polymorphism in the Magnesium Transporter When More is Not Necessarily Better: Interdisciplinary Inquiry into the Implications of U-shaped Dose Responses for Personalizing Anticancer Interventions Characterised Nanomaterials for Biomarker Profiling Based Cancer Detection 17:30 Antiparasitic compounds - Magic
Diagnosis and Innovative Therapy of Human specific Enterocytozoon bieneusi Bullets against various parasites
Genotype D Strain in Falcons (Falconiformes) The fecundity of Schistosoma japaoniucm was impaired by administration of low dose cyclophophamide A Randomized Double Blind Two Arms Community Trial to Assess Activity of Doxycycline on Bancroftian Filariasis Worm Nests, Orchitis, Hydrocoecele and Sub-clinical hydrocoele Percutaneous absorption of crotamiton in man following single and multiple dosing.
2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
17:30 Antivirals - Clinical effectiveness
Treatment of intravenous drug users with chronic hepatitis C: treatment response, compliance and side effects Enveloped virus neutralizing antiviral compounds, the magic bullets against a broad spectrum of deadly viral diseases.causing a billion infections annually around the globe Re-infection with Varicella Zoster in older people Detection Of Lamivudine And Adefovir Resistant Hepatitis B Virus Polymerase Gene Variants During Two Years Antiviral Theraphy Of Chronic Hepatitis B Patients In The South Of Turkey Ganciclovir treatment of infants with cytomegalovirus infection and central nervous system involvement Spectrum and risk for HIV-1 associated mutations and the efficacy of antiretroviral therapy among infected pediatric patients Residue Networks and Drug Resistance in Hepatitis C Virus Antiviral Therapy 17:30 Biosimilars / Follow-on Proteins and
their challenges to manufacturers
and regulatory bodies - Part I
Phase I - study of an erythropoietin biosimilar Bioequivalence of biosimilars - is pharmacodynamic equivalence sufficient? 17:30 Cardiovascular - Pharmacological
Absorption and Disposition of the Renin Inhibitor Drug Aliskiren action in the cardiovascular system
from small molecules to peptides
and vaccines - Part I
The Efficacy of Influenza Vaccine in Reducing Cardiovascular Events in Patients with Coronary Artery Diseases (IVCAD) 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
17:30 Treatment of asthma, COPD, and
Budesonide - Breath-giving innovation for asthma patients other lung diseases - Part I
NEW HORIZONS IN RESPIRATORY ALLERGY THERAPY AND “MAGIC BULLETS”: COULD IT BE POSSIBLE TO INCLUDE ANTIPROTOZOAL DRUGS? Synthesis of a Series of 8-(Substituted-Phenyl)xanthines and a Study on the Effects of Substitution Pattern of Phenyl Substituents on Affinity for Adenosine A1 and A2A Receptors- The Magic of Theophylline 17:30 Immunosuppressants - Part I
Pharmacogenetic and pharmacokinetic approaches in renal and hepatic transplantation NVP-AEB071: Oral and Specific Inhibitor of T cell Activation for the Prevention of Graft Rejection and the Treatment of Autoimmune Diseases Blocking Effect of an Immuno-Suppressive Agent, Cynarin, on CD28 of T-Cell Receptor Found by a Novel Pharmaceutical Method 20:00 New drug concepts
Open chemical databases and ontologies in the genomic age Energetics of Cytochrome P450 Hydroxylations: Making Sense of In Silico Inhibitors of Serine/Threonine Protein Phosphatases at the Dawn of a Clinical Era. COMBINATORIAL NANOBIOTECHNOLOGY - A PARADIGM SHIFT IN CHEMISTRY AND MATERIAL SCIENCE Alpha1-antitrypsin augmentation therapy: new insights into the molecular basis of efficacy What Sort of Light Is At the End Of the Tunnel In Anti-Allergic Drugs? 20:00 Pharmaceutics - Drug delivery
Penetration of Bioactive Proteins and Peptides across Stratified Mucosae in a Porcine through the skin - Part I
Transdermal Delivery of Naltrexone, In Vitro Testing to Human Volunteers Fentanyl: How delivery system can modify clinical properties of molecule Hydrogels for sustained and selective release of diclofenac 20:00 Vaccines - Antiinfectives - Bacteria
and parasites - Part I
Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
20:00 Pharmaceutics - Reviews and
Pharmaceutical Policy in Context of Health care System in Albania general aspects
Medicinal effects of maca: Experimental data on reproduction, memory and learning A Cost -Benefit Approach to Sample Size Determination for Clinical Trials with Binary Responses Exploiting Plant Sources for Potential Drugs. Alpinumisoflavones in Perspective Biopharmaceutical and Pharmacokinetic Searches of Drugs in Perinatology (1968-2008) The role of ancient Iraqi People (Sumerian, Assyrian, Babylonian and Arabian) in the development of medicine as viewed by western writers 20:00 Pharmacokinetic studies and drug
Pharmacokinetic study of rivastigmine in Iranian healthy subjects following 3 and 4.5 metabolism
mg dosing using a simple and sensitive HPLC-UV method Role of drug metabolism in the development of Eplerenone: A lesson learned from Spironolactone Pharmacokinetic Study of Saltz Regimen for Advanced Colorectal Carcinoma under Hemodialysis BIOEQUIVALENCE AND PHARMACOKINETIC STUDIES OF FIVE ANTIRETROVIRAL GENERIC DRUGS IN HIV/aids CUBAN PATIENTS Generics versus originator drugs: Analysis of paracetamol and Ibuprofen tablets in the Nigerian Market Indocyanine green-revisiting an old friend.
2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
20:00 Therapeutic Proteins - clinical
Can Erythropoietin be used to prevent brain injury in children with cerebral malaria? studies - Part I
Applications of recombinant human epidermal growth factor in the treatment of hard-to-heal wounds A Bevacizumab, An Anti-VEGF Antibody, As A MAGIC BULLET for Retinal Disease? Optimized Productions of Recombinant Human Proteins, an Enzyme and Two Cytokines, in Fermentor Cultures of the Yeast, Pichia pastoris Commercialization of Recombinant Human Epidermal Growth Factor – A Nobel Prize Winning Molecule with Diverse Therapeutic Applications Designing Novel Drugs for Neurological Disorders: The Development of TRH-based Neurotherapeutics 20:00 Biosimilars / Follow-on Proteins and
Immunogenicity of biopharmaceuticals - An inconvenient truth their challenges to manufacturers
and regulatory bodies - Part II
20:00 Vaccines - Targeting non-infectious
EMY162 Protein as a Vaccine Candidate to Reduce Level of Alveolar Hydatid Disease diseases - Part I
TREATMENT AND RELOCATION OF WHEAT FLOUR SENSITIZED WORKERS BY AN ALLERGENIC VACCINE Psoriasis [Ps]: A Possinle Candidate for Vaccination The Modified Vaccination Technique developed by Barabas provides the “magic bullet” for the prevention and cure of chronic ailments such as autoimmune disorders and cancer specifically, without side effects 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
20:00 Anti-infectives - Mechanisms of
Resistance, Including Carbapenem Resistance, Among Enterobacteriaceae In a bacterial resistance - Part I
Functional characterization of outer membrane proteome in response to antibiotic resistance A Molecular Perspective on Integron-Associated and Transferable Antibiotic Resistance in Clinical and Aquatic Isolates of Gram-Negative Bacteria in Northern Region of Turkey Bacterial drug efflux pumps: significance for antibiotic resistance and pathogenicity.
Mechanism of Fluoroquinolone resistance in Shigella and Salmonella species 20:00 Antineoplastic agents - Clinical trials 1518 Nishida
Cryoimmunology induced after reimplantation of malignant bone tumor treated with and approaches- Part I
Ras as a target for exploratory study of monoterpene perillyl alcohol intranasal administration in patients with recurrent gliomas Methotrexate – the past and the present Magic bullet and magic shield: a new strategy to target Survivin in human cancers Estrogen Metabolites in the Control of Osteosarcoma Prevention of Mucositis and Improvement in Compliance of Head & Neck Cancer Patients undergoing Radio-Chemotherapy by Curcumin 20:00 Antineoplastic agents - New
approaches to antineoplastic
therapy and cell survival - Part I
TLN-4601, a novel anticancer agent inhibits Ras signaling through Raf-1 degradation L-type-like calcium channels in non-excitable cells: critical roles in cell survival 20:00 Antiparasitic compounds - Malaria
Antibacterial, Antisecretory and Antihemorrhagic Activity of Azadirachta indica Used to Therapy and approaches
Epidemiology of Malaria in India and Intervention Measures Comparative Study of Dihydroartemisinin and Artesunate Safety in Healthy Thai Volunteers Antimalarial drug resistance in Indonesia: A molecular analysis 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
20:00 Blood-brain barrier - History and
Paul Erlich: The blood-brain Barrier and the search for the magic bullet.
most recent finding - Part II
Brain cholesterol ? Long secret life behind a barrier Poor permeability of blood brain barrier for creatine: Autonomous brain synthesis of creatine, and consequences for creatine deficiency syndromes Pecularities of Blood-Brain-Barrier Penetration of Pralidoxime 20:00 Treatment of diseases with
The Effect of Melatonin and Zinc on the Immune Response in Experimental involvement of the immune system -
Short-term, low dose methotrexate: a regimen for immune tolerance induction Potential of JAK/STAT inhibitors for treating RA Oral tolerance as a method of suppression of immunological response in experimental auroimmune encephalomyelitis RADIODETOXIFIED ENDOTOXIN AS IMMUNOMODULATOR (A new “MAGIC BULLET”) Mechanisms of anti-CD20 immunotherapy: Why Type II mAb are better 20:00 Pharmaceutics - Pharmacokinetics
Which gliclazide (GLC) formulation tablets, immediate (IR) or modified release (MR), and drug formulations - Part I
Reduction of Flubiprofen-Induced Gastric Toxicity by Prodrug Formation and Enhancement of Oral Bioavailability of Flubiprofen by Chitosan Complexation DRUG ABSORPTION FROM THE SMALL INTESTINE IN IMMEDIATE POSTOPERATIVE PATIENTS controlling of systemic absorption of gliclazide through incorporation into alginate beads The use of permeability and reference compound data for predictions and understanding of human pharmacokinetics 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
20:00 Vaccines - Antiinfectives - Malaria &
Studies on New Tuberculosis Vaccine Candidates in Animal models Tuberculosis
CONSTRUCTION -DEPENDENT DNA LIPOSOME EFECTIVENESS ON TUBERCULOSIS VACCINATION The dynamic hypothesis of latent tuberculosis infection offers a new rational to develop future therapeutic strategies. Cultured Plasmodium Sporozoites as a Potential Malaria Vaccine Status of BCG vaccine at the beginning of the 21st century Title: Severing the Gordian Knot: Are Glycolipids the solution for Effective Vaccines against Malaria and HIV? 07:15 Agents / diseases affecting the
A biomarker panel for acute graft versus host disease immune system - Part II
Magic bullets against the autoimmune diseases The Pathogenesis of Autoimmune Diseases: New Possibilities for Drug Development Differently Directed Changes in Interferon-? Production Depending on Radioadaptive Response.
High Throughput Screening for In Vitro Toxicity Screening: A Gradual Acceptance of New Test Methods Toll-Like Receptor (TLR) Agonists and the Induction of the Innate Immune Response Pharmacodynamic monitoring of calcineurin inhibition therapy 07:15 Analgesia & analgetic drugs II
Valproic Acid (VA) May Be Effective in the Treatment of Headaches Associated with Reactivation of Cerebral Toxoplasmosis (CT) Neuropeptide FF receptors: a novel target for pain treatment Quality of life in patients with cancer pain treated by controlled release tramadol and dihydrocodeine Neurotensin Agonists: Novel Analgesics with Synergy to Morphine 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
07:15 Antibacterials - New and innovative
The piggy back approach or how to find new lead structures for antiinfective or approaches to discover and develop
antimicrobials - Part III
The new biocidal agents with the high sporicidal efficiency New derivatives of BM 212 with improved antimycobacterial activity.
Rediscovering antibiotics of alternative medicine: case of apitherapy Desining Novel Antimicrobial Concepsts Combining Nanotechnology, Bioplastics and Natural Products 07:15 Anticoagulation and heparin-based
An enzymatic approach for developing heparan sulfate-based drugs Innovation in Anticoagulation: The Discovery and Development of Novel Small Molecule Coagulation Inhibitors as New Treatment Option for Thromboembolic Diseases A Therapeutic Conundrum: Low molecular weight heparins in patients with kidney dysfunction.
Antithrombotics that do not induce bleeding: the “holy grail” found by interfering with von Willebrand factor 07:15 Antifungals - Optimizing treatment in 1088 Dhar
Antifungal therapy in cardiothoracic transplant recipients in a new prescribing era normal and special populations
Vindesine and Razoxane, an Effective Drug Combination for Soft Tissue Sarcomas Antifungals in the treatment of candidiasis eruption during treatment oral autoimmune diseases Newer antifungal drugs in kidney transplant recipients Treating fungal infections with CYP53A15 inhibitor 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
07:15 Antineoplastic agents - in vitro and
Sodium and Diffusion MRI as Biomarkers of Initial Tumor Response to Therapy in The Therapeutic “Cure” of Xenograft Tumors by the Third Generation Epothilone: Iso-oxazole-Fludelone Evidence for anti cancer actvity for the anti depressant sertraline, in vitro and in vivo effect in nude mice xenografted with HT29 cells.
The pharmacokinetics, pharmacodynamics and clinical trials of platinum analogs in birds Prodrugs of histone deacetylase inhibitors in combination with doxorubicin impart improved anticancer activity and reduced toxicity by differentially affecting tumor versus normal tissue 07:15 Antineoplastic agents - New
Epigenetic Therapy using 5-Aza-2'-deoxycytine: A Magic Bullet Against Cancer mechanisms & compounds - Part II
Cell cycle kinases as molecular targets in anticancer therapy »Carbon bullet«: Fullerenol C60(OH)24 as organo-protector against doxorubicin-induced toxicity 'Targeting the Redox Achilles Heel of Cancer Using NQO1-Activated Phenothiazinium Redox Cyclers'.
Acridine orange found in Ehrlich’s era could become a “Magic Bullet” against cancer under photon energy 07:15 Bioanalytics - The cutting edge of LC-
The combined use of HPLC, Gel-LC-MS/MS and microarray in monitoring product MS/MS - Part I
Drug Screening of Preserved Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry Liquid chromatography-tandem mass spectrometry assay for determination of raloxifene and its two glucuronide metabolites in human plasma and serum 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
07:15 Clinical studies with agents of
Treatment of hepatic abscess: Magic bullets and beyond different pharmacological activity -
Part III
Prospective Magic Bullet Cobalt: Its Effect, Mode of Action and Utility for Hypoxic Study Magic bullets for the treatment of inflammatory bowel disase - yet to come? Genetic polymorphisms of cytochromes P450 influence the Leflunomide treatment and toxicity in rheumatoid arthritis patients Deferoxamine and Defersirox as magic bullets against iron overload 07:15 CNS - Pharmacological options in
Neuronal trafficking of proteins involved in synaptic plasticity: a GFP-based approach disease of the central nervous
system - Part III
Melatonin-a possible magic bullet in reducing hypoxic brain injury MAGIC BULLETS FOR THE TREATMENT OF OXIDATIVE STRESS-INDUCED NEURODEGENERATIVE DISORDERS Lacosamide is a Novel Antinociceptive and Antiepileptic Drug with a Dual Mode of Action Caffeine sets the brain’s excitability by priming the activation of the endogenous cannabinoid system Atorvastatin protects spinal motor neurons from glutamate mediated neurotoxicity 07:15 Doping and performance
Growth Hormone: how to catch the magic bullet of the modern athlete enhancement drugs
Magic bullet or magic diet: The need for further understanding in sport performance enhancements ILLICIT DRUGS AND CARDIAC ARRHYTHMIAS IN ATHLETES Myostatin Inhibiting Peptide Works as a Magic Bullet to Increase Skeletal Muscle Mass and to Ameliorate Muscle Pathology in Muscular Diseases by Transgenic Expression 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
07:15 Pharmaceutics - Discovery of drugs
Purposeful Drug-Excipients Physico-Chemical Interactions – What does that mean for and mechanisms - Part II
Optimization of Drug Delivery and Safety? Bioartificial Human Tissues as Model Systems for Pharmaceutical Target Screening and Drug Development CROSS-REACTIVITY AND IDENTIFICATION OF T AND B EPITOPES IN PLANT FOOD ALLERGENS: PEACH PRU P 3 AS A MODEL Transient Drugs as Magic Bullets: A New Approach to Drug Discovery Modulation of the structure of a lipid membrane for selective interactions with a drug 07:15 Physiology & Magic Bullets - Part II
Mitochondrial Respiratory Chain (MRC) and Mitochondrial Permeability Transition (MPT) Effectors against Heavy Metal-induced Cytotoxicity: State-of-the-art and Perspective Chelating Agents for Treatment of Uranium-induced Toxicity in Radiation Emergency Medicine Activation of LINE DNA in realization of adaptive response Fluoride and Aluminum Interactions: AlFx as the MAGIC BULLETS Producing Aberration of G Proteins A role for lysosomal phospholipase A2 in cationic amphiphilic drug-induced phospholipidosis. (Oral form) Snake and snail neurotoxins – magic tools for targeting different subtypes of nicotinic acetylcholine receptors 07:15 Recombinant Proteins - a new class
Kinetic Properties of Recombinant Factor VIIa (rFVIIa) and the Complexity Relating of Magic Bullets- Part II
PHARMACOKINETICS AND BIOLOGICAL EFFECTS OF THE RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 IN VIVO Dissecting the DNA Base Excision Repair Pathway: Implications for Cancer Therapy Dynamics Based Design of Anti-Prion Compounds Uncovered the Hot Spots for Prion‘s Pathogenic Conversion Reaction Metallic gold reduce TNF? expression, oxidative DNA damage and pro-apoptotic signals in brain injured mice. Epitopic Peptides with Low-Similarity to the Host Proteome. Towards the Magic Bullets 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
07:15 Biomarkers - The thorny way to
It's not only genes - The many dimensions of personalized medicine personalized medicine
CURRENT KNOWLEDGE ON TRANSPORTERS OF VITAMIN A AND ITS PRECURSORS Transient Activation of the Small GTPase Rap1 is Functionally Required for the Regulation of Breast Cancer Cell Motile Responses to IGF-I Personalized management of breast cancer: Promises and Challenges of Genetic Testing and Genomewide Association Studies Personalized Medication with Estramustine Phosphate for Advanced Prostate Cancer after Screening of the CYP1A1 gene polymorphisms Pharmacogenomic targetting of Ehrlich's magic bullet New Biomarkers and Targeted Therapies for Breast Cancer 07:15 Antineoplastic agents - how to find
Novel Antineoplastic Agent – Peptide Conjugates as Drug Delivery Systems for new Magic Bullets
Anticancer activities of vitamin D analogs Titanium-Based Magic Bullets Against Renal-Cell Cancer Inhibitory Effects of Demecolcine on NK Cell Functions: Implications for Cancer Therapy Asparagine Synthetase Inhibitors with Nanomolar Potency: An Unexplored Approach to Treating Drug-Resistant Leukemia INVESTIGATION OF DIBENZYL TRISULPHIDE (DTS) ISOLATED FROM PETIVERIA ALLIACEA AS AN IMMUNOMODULATOR WITH CYTOTOXIC/ANTI-PROLIFERATION ACTIVITY 07:15 Clinical situations & therapy and
Calcium-releasing Agent Exhibits Bioactive Effects in Endodontic Therapy cellular therapeutics
Metoclopramide Does Not Influence the Incidence of Propofol-Induced Spontaneous Movements Missile Injuries Of Orofacial Region, Primary and Secondary Management The insulin-stem cell connection: what insulin does to stem cells and how we get it from them The Psychological Outcome of Male Constitutional Delay Short Stature Adult stem cells are a source of paracrine factors for tissue regeneration 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
07:15 Endocrinology including diabetes
Targeting Cell Cycle Progression by Troglitazone.
Dipeptidyl peptidase 4 inhibitors: a new class of oral agents for the treatment of type 2 diabetes mellitus Towards a Magic Bullet for the Metabolic Syndrome – Use of the Ginkgo Biloba Extract Drug discovery related to vaspin, visceral adipose-tissue derived serine protease inhibitor, a novel adipokine with insulin-sensitizing effects.
Insulin, IGF-1 and Rosiglitazone: How Do They Effect The Glucose Metabolism and Insulin Resistance in Human SH-SY5Y Cells with Alzheimer Key Proteins? The Importance of Appropriate Animal Models for Evaluating Agents for Proliferative Retinopathy: Failure of Combretastatin to inhibit Diabetes-Like Proliferative Retinopathy in the Galactose-Fed Dog 07:15 Illicit drugs & similar agents and
Ecstasy – The Pharmacology of Happiness addiction
Cellular Immune Toxicity of Alcohol and Cocaine: Medical Practice Based on the Evidence vs. Evidence-Based Medical Practice Identification of the cocaine binding site on the dopamine transporter Dopamine transporter as the target and carrier of illicit and therapeutic drugs – PK/PD approaches to develop MAGIC BULLETS for cocaine abuse Political Economy and Societal Consequences of Methamphetamine Epidemic in the United States 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Target site interactions and
New animal models for psychotropic drug-drug interactions spectroscopic / computational
approaches
Circular dichroism spectroscopy in stereochemical studies of b-lactam antibiotic analogues Interactions Between Drug Target Binding Sites and the Remarkable Story of Dopamine D1/D2 Synergism Dissociation of Multi-molecular Drug Complexes and Multi-site Binding to 7-TM Receptors: Protection, Delivery and Enhancement of Adrenergic Activation by Ascorbate Consideration of Metachromatic Spectral Changes of Toluidine Blue Staining of DNA Depending on its Helical Structure Molecular modelling of inhibitor-kinase interactions. 'Icy', highly polarized water molecules can tip the relative energy balances of competing inhibitors 09:30 Pharmaceutics - Experimental and
Modern quantum chemical descriptors for QSAR/QSPR computational approaches - Part II
09:30 Antibacterials - Clinical Aspects -
Effectiveness Of Antibiotics In The Management Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease. Do Antibiotics Improve Patient Outcomes – Evidence To Date Decontamination of Cardiovascular Allografts in European Homograft Bank (EHB). Comparison of different Antibiotic Cocktails in low Concentration low Temperature Conditions Addition of Local Antiseptic Spray to Antibiotic regime reduces the incidence of stomal infection following Percutaneous Endoscopic Gastrostomy (PEG) – a randomised controlled Antibiotic treatment of Clostrudium difficile - does it work? New Silver Compounds as Wound Healing Material Problems and Opportunities The treatment of patients with multi-drug resistant cavitary pulmonary tuberculosis with gelatin containing anti-tuberculosis medicines by fiberbronchoscope Reduction of surgical infection in pediatric cardiac surgery 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Ehrlich History, Reviews and Future
Passive Immunization for the Protection of our Global Society against Emerging perspectives on Ehrlich’s Research
The legacy of Paul Ehrlich to antimalarial chemotherapy.
Two vaccines too far: the polio vaccine fiascos of 1935 09:30 Anti-infectives - Approaches to
IgY (Immunglobuline from egg-Yolk) - a “magic bullet” to fight antibiotic resistance.
combat resistance
Transferable Resistance to Five Different Classes of Protein Biosynthesis Inhibitors Including Oxazolidinones Mediated by the Gene cfr in Staphylococci 1240 Mollazadeh Moghaddam Trans-Cinnamaldehyde from Cinnamomum zeylanicum Bark Essential Oil Reduces the Clindamycin Resistance of Clostridium difficile In Vitro 09:30 HPLC, capillary electrophoresis, and
Application of Electrochemical Analysis to the Determination of (A), Trace Amounts other analytical techniques
Minoxidil in Hamster Skin Follicles and (B), Residual Hydrogen Peroxide Present in the Minoxidil Formulation Excipients Pharmaceutical Analysis using Sequential Injection Analysis (SIA): A review of present Applications and future possibilities Analysis of linezolid chiral and achiral impurities by capillary electrophoresis Amperometric biosensor development and their clinical application Angiotensin Converting Enzyme Inhibitors Determination in Plasma by Enzyme Kinetic and High-Performance Liquid Chromatography Laser-based Stable Isotope Tracing in Human Breath Introduction of supercritical fluid extraction as a new sample-preparation procedure for isolation and identification of a pharmaceutical from biological fluids: Application to disposition kinetics 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Antibacterials - Tissue penetration of
Evaluating our Performance: Tissue Penetration Paradigm Shift anti-infectives
Pharmacokinetics of Macrolides and Ketolides – where is the drug and how do we measure it? Infection Site Concentration of Metronidazole (MTZ) and Meropenem (MER) in Patients with Septic Shock (SS) Serum and Alveolar Concentrations of Antibiotics during the Treatment of Ventilator-Associated Pneumonia The Ocular Penetration of Antibiotics Using a Rabbit Model that Emulates Human Topical Dosing 09:30 Antibacterials - Adverse events and
The Proarrhythmic Potential of Macrolides: The Role of Interactions. A Review mechanisms of toxicity - Part II
When Magic Bullets Cause Collateral Damage (SJS/TEN & AGEP) Enerceuticals Mediated Activation of the Alternative Cellular Energy (ACE) Pathway in the Therapy of Infectious Diseases 09:30 Antibacterials - Discovery - Peptide
Antimicrobial peptides from bacteria: towards novel magic bullet startegies? antibiotics - Part II
LACTOFERRIN ACTS AGAINST INFECTION AND INFLAMMATION THROUGH ITS INFLUENCE ON SYSTEMIC IRON HOMEOSTASIS 09:30 Antibacterials - Looking at the fate of
Quinolones and Metal Ions- Friends or Enemies? anti-infectives in- and outside the
body - Part II
09:30 Vaccines - Antiinfectives - Influenza
Sculpting the Immunological Response to Dengue Fever by Polytopic Vaccination and other viruses
Development of an Inactivated Rotavirus Vaccine for the Global Immunization Agenda Advanced development of seasonal and pandemic influenza vaccines Vaccination in Patients with Cancer: Strategies to Prevent Influenza and Pneumococcal Disease High uptake of vaccines – a „magic bullet” in control the burden of hospitalisation attributable to childhood mumps and rotavirus infections.
2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Vaccines - Antineoplastic - Role of
RNA-modified dendritic cells as therapeutic cancer vaccines: Dressed for success ? immune cells - Part I
EGFRvIII-targeted vaccine (CDX-110) induces immune responses and prolongs survival when given with temozolomide in GBM patients 09:30 Antifungals - Pharmacokinetics and
Pharmacokinetics of anitmycotic drugs during continuous renal replacement therapy formulation issues
Complexation of Itraconazole with Cyclodextrins for Enhanced Solubility, Dissolution and Bioavailability 09:30 Antifungals - New approaches and
(-)-?-Bisabolol – a Specific Ergosterol Biosynthesis Inhibitor ? their success
Mannose-binding lectin in the defence against genital candida infections.
In Vitro Antifungal Synergy Between the Plant Saponin, CAY-1, and (1) Two CAY-1 Structurally Related, Inactive Saponins and (2) Silver Vulvovaginal Colonization by Aspergillus Species in Nonimmunocompromised Women 09:30 Antibacterials - New mechanisms
Gut Health-Promoting Adhesion Of Enteropathogens To Dietary Polysaccharides and delivery strategies - Part II
Perspective of chromatin structure on Topoisomerase II: Exclusive dynamics between the nucleosome and the drug target in Saccharomyces cerevisiae The impact of a mixture of doxycycline, an acid and a detergent on root canal debridement 09:30 Antibacterials - Peptide antibiotics
and their intricacies
Polymyxin B: how this Magic Bullet kills Gram-negative Bacteria? 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Antineoplastic agents - Compounds
The natural NFkB/IKK2 inhibitor and steroidal withanolide Withaferin A, isolated from and approaches - Part II
leaf extract of the Ayurvedic plant Withania somnifera Dunal (Ashwagandha), is a novel promising chemosensitising compound in B-cell chronic lymphocytic leukemia and metastatic breast cancer Membrane transport of alkaloids and anticancer drugs in plants: specificity and analogy to mammalian cells Molecular pathogenesis and targeted treatment in BCR-ABL negative chronic myeloproliferative neoplasms".
09:30 Antineoplastic agents - Delivering a
Targeted delivery of cisplatin using polymeric nanoparticles Magic Bullet to its target(s) - Part II
pH Dependent 5-Fluorouracil Release System using Polymeric Micelles Design of Folate-linked Liposomal Doxorubicin to its Antitumor Effect in Mice New Applications for Micro- and Nanoscaled Drug Delivery Systems 09:30 Antineoplastic agents - New targets
Targeting the vulnerability of cancer cell mitochondria to selectively induce apoptosis: & compounds - Part II
Evaluating the efficacy of Pancratistatin as a non-toxic anti-cancer agent Small Peptides Challenge Thymidylate Synthase Dimerization and Inhibit Ovarian Cancer Cells Growth Novel clinically relevant proteasome inhibitors and HDAC inhibitors 09:30 Antineoplastic agents - Effects of
THE DEVELOPMENT OF TUMOR-INHIBITING METAL COMPLEXES: well known anti-tumor agents and
(MULTINUCLEAR) METAL COMPLEXES and MODE-OF-ACTION STUDIES drugs with other primary action -
Part II
The Anti-Tumor Action of the Hybrid Drug Nitric Oxide-Donating Aspirin Relies on the ‘Passive’ Linker and not on Nitric Oxide Nor on Aspirin: An Overview of an Interesting Twist 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Treatment of asthma, COPD, and
Variability of the Systemic Availability of Budesonide in Man when Administered other lung diseases - Part II
Locally at Different Levels in the Gut with Different Doses of Ketoconazole Cotrimoxazole an 'old magic bullet' finds a new target and benefit in Advanced fibrotic lung disease Omalizumab: the first real magic bullet for the treatment of allergic asthma? 09:30 Parkinson's disease, mechanism of
Rasagiline, a Selective Suicide Inhibitor of Monoamine Oxidase B, Increases Striatal disease and treatment - Part I
Extracellular Fluid Dopamine Levels and Locomotor Stimulation Following L-dopa Without a Corresponding Increase in Dyskinetic Movements in a Parkinsonian Rat Model Behavioural and cellular consequences of excessive amounts of the powerful brain chemical dopamine.
PARKINSON DISEASE - PARKINSONISMS - Etiopathogenesis - Treatment IS LEVODOPA THE MAGIC BULLET FOR PARKINSON'S DISEASE? 09:30 Vaccines - Physiology and molecular
The Role of cell membrane lipid environment in antigenic peptide structure-function biology - Part II
The F1-V Plague Vaccine Can Activate the Innate Immune Response Through Toll-Like Receptor2 and 4 but Does Not Need Them for an Antibody Response to the Vaccine Adoptive immunotherapy with Streptamer-selected HCMV specific T-cells after allogeneic stem cell transplantation Anti-Idiotypic Vaccines Against Autologous Antigens: Designed Ankyrin Repeat Proteins as Scaffolds to Break Self Tolerance? Virus-Like Particles As Magic Bullets For Immune System Innovative Method For Quality Control of High Molecular Weight Semi-synthetic Vaccines 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Cardiovascular - Pharmacological
Pharmacokinetic-Pharmacodynamic Modeling of Aliskiren Effects on Biomarkers of action in the cardiovascular system
from small molecules to peptides
and vaccines - Part II
Targeted Pulmonary Delivery of Aerosolized PGE1: A “Magic Bullet” for Neonatal Pulmonary Hypertension? Trimetazidine Revisited: Current and Future Applications of Metabolic Modulation of the Heart The changes in renal function after a single dose of intravenous furosemide in patients with compensated liver cirrhosis 09:30 Anti-infectives - Reviews on Magic
Ear Surgery – Place for Topical use of Mitomycin C Bullets - Part I
Levofloxacine for typhoid fever: A Story of Unlimited Success Isoniazid: It Was or It Is a Magic Bullet? 09:30 Ehrlich`s research fields: Historical
Magic Bullets versus Shotgun Drugs in Cancer Therapy and Prevention aspects and latest research results
How Did The MAGIC BULLETS Drop The Knife Out of The Surgeon's Hand.
Antibiotic magic bullets: The promise and the reality of the past 30 years.
From immunity theory to anti-infectious chemotherapy. Why awarding two Nobel prices in 1908 to Paul Ehrlich (from Germany) and Elie Metchnikoff (from France). What consequences for medical research? Globalization and influence of Nobel prize winners for medicine and physiology to development of modern medicine during 20th and 21st century Receptors for Magic Bullets. Ehrlich, Precursor of Receptor-mediated Drug Action. Application to Age-related Pathologies. A Review 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 New / known targets & mechanisms - 967
Macromolecular Conjugates for Passive Tumor Targeting: In Vitro Studies with a A common molecular basis for ryanodine receptor dysfunction in malignant hyperthermia and catecholaminergic polymorphic ventricular tachycardia provides opportunities for novel therapeutic strategies Control of ceramide levels by ceramide kinase: evidence from knockout animals and use of a novel potent inhibitor Dual mechanistic anorexigenic and anti-adipogenic therapeutic for the treatment of obesity Differential Targeting of Immune Response after Antigen Encounter at Different Mucosal Sites – a Tool For Vaccine Development Prostones as ClC-2 Channel Activators for Treatment of Diseases and Disorders.
New targets for new drug discovery opportunities 09:30 Vaccines - Antineoplastic - Antigen
Antibody responses in cancer vaccines and immunotherapies: from cancer/testis antigens to new targets discovered by protein arrays Cancer-testis antigens: effective molecules for developing successful immunotherapeutic strategies in the light of cancer complexity Melanoma initiating cells: new perspectives in therapy? AdCD40L Cancer Vaccine ? From Experimental Models to Clinical Application Direct lentiviral injection induces potent anti-CEA immunity in CEA transgenic mice Designing Vaccines for Cancer: Synthetic Analogs and Nano-Delivery Approaches FUSION PROTEINS FOR FLEXIBLE VACCINE ANTIGEN TARGETING TO CELL SURFACE RECEPTORS 09:30 Vaccines - Antiinfectives - Bacteria,
Nasal Vaccination against Bacterial Toxins parasites, and HPV
09:30 New findings on purines
P2X purinergic receptor modulation of excitatory nociceptive transmission involve NMDA receptors Adenosine: Magic bullet against disordered sleep? Non-selective and selective adenosine receptor agonists in the treatment of radiation- and chemotherapy-induced myelosuppression Adenosine-Based Therapies for Hearing Loss 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
09:30 Anti-infectives - Mechanisms of
A Computationally Designed Mutant of the Metallo-b-lactamase IMP-1 Exhibits bacterial resistance - Part II
Dodging the bullets: an update on the multi-drug efflux pump P-glycoprotein Counteracting drug resistance by nutritional management and genetic improvement of disease resistance - lessons from in-silico studies for nematode infections of sheep 09:30 Treatment of tuberculosis and other
Intrinsic antibiotic resistance mechanisms of Mycobacteria infections
The “antiinflammatory” 5-ASA, “immune-modulators” azathioprine, 6-MP, methotrexate & thalidomide and “immune-suppressants” Cyclosporine A, Rapamycin & Tacrolimus are all unsuspected “Magic Bullets” the inhibit M. avium subspecies paratuberculosis growth in culture Fluoroquinolones in the Treatment of Tuberculosis : current status and future issues.
TNF mAbs: Magic bullets for tuberculosis? Improving treatment of urinary tract infections in elderly : roles and functions of information technologies to suggest antibiotic prescriptions and to measure their effects Tetracyclines: a historical pitfall and additional concept on the treatment of rickettsial diseases From 4 to 1 weeks of treatment down to a single-dose application: a novel topical formulation of terbinafine for dermatophytoses 12:00 Antiparasitic compounds - Molecular 1308 Kagawa
Antibody based protein-function analysis on the ryanodine receptor and troponin and genomic approaches
Levamisole Resistance in Parasitic NematodesInvestigated at the Molecular Level A GENOMIC PARASITE IN THE EVOLUTION OF METAZOAN DEVELOPMENT Control of Infective Aphids in Tunisia using Molecular Tools: Biotechnological Approach to protect Food Crops.
2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
12:00 Atherosclerosis, stroke & aging -
The Utility of the Cholestanol:Cholesterol Ratio in Predicting LDL-Cholesterol mechanisms and treatment - Part II
response to Atorvastatin 80 mg: A paradigm for individualized lipid-lowering therapy EFFECT of FISH OIL (MEGA-3) AND GARLIC OIL (GARLIC PEARLS) SUPPLEMENTATION ON THE ANTHROPOMETRIC MEASUREMENTS,BLOOD PRESSURE AND SERUM LIPID PROFILE IN WOMEN WITH HYPERCHOLESTEROLEMIA 12:00 Cardiovascular - Drugs acting on the 1078 Asgeirsdottir
Targeting Dexamethasone-Loaded anti-E-selectin Liposomes Prevents cardiovascular system - Part III
Glomerulonephritis Progression: The Potential of Vascular Bed-Specific Drug Delivery Generating C-reactive protein inhibitors for the treatment of cardiovascular disease 12:00 Cardiovascular - Magic Bullets & the
Central sympatholytic and anti-arrhythmic effects of 5-HT1A agonists cardiovascular system - Part I
Rimonabant, first CB1 receptor antagonist, a potential magic bullet to reduce cardiometabolic risk in patients with abdominal obesity Beyond cholesterol lowering: Immunomodulatory effects of lovastatin Novel targets and magic bullets for treating cardiovascular disease Hyaluronan Mixed Esters of Butyric and Retinoic Acids: Multicomponent-Multitarget Drugs with Differentiating and Paracrine Logics for Cardiovascular Repair with Human Mesenchymal Stem Cells Nifedipine, the most citated, studied, experienced and debated ca-antagonist: where has it gone? 12:00 Vaccines - History, Reviews, and
Dissemination and Communication: Selling Vaccines to Peers and the General Public Future Perspectives - Part I
Vaccine Adjuvants for Sexually Transmitted Infections: Recent Developments and Future Challenges The success story of Japanese DTaP control and a further development of vaccine evaluation The VesiVax® System: Vaccinology’s Magic Bullet? The Vienna Vaccine Safety Initiative (ViVI) – an International Scientific Forum aiming to Promote Evidence-based Vaccine Safety Research and Communication 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
12:00 Antibacterials - Unexpected findings
Xylitol Resistance of Streptococcus mutans Appears To Be An Unexpected Benefit to and new approaches
Pathophysiology of Enteropathogenic E. coli-induced diarrhea: Potential Therapeutic Role of Probiotics Competitive interactions in Escherichia coli populations: the role of Bacteriocins Stimulation of Proline Uptake and Growth of Escherichia coli CSH4 and its Mutants under High Salinity through Moderate Salinity Stress Treatment Silkworm infection models to evaluate the therapeutic effects of antibiotics 12:00 Antibacterials - New antibiotic and
Sperm immobilization factor: potential candidate for fertility control and antibacterial antineoplastic compounds from
nature - Part II
Inter-kingdom cell-to-cell inhibitors: a novel target for antimicrobial drugs.
Predatory Bdellovibrio bacteria as living antibiotics:- Nature's Magic Bullets to treat antibiotic-resistant Gram-negative infections.
A Series of Antibacterial Toxins Made from Inactive Cyt-Like ORF of Bacillus thuringiensis subsp. israelensis Using The Microgene Polymerization Reaction Exploring Anti-microbial Herbs of Chinese Medicine.
12:00 Antineoplastic agents - Balancing
Effectiveness and complications of treatment for childhood liver tumors – from the efficacy and toxicity
experience of JPLT (Japanese Study Group for Pediatric Liver Tumor) study Light (LM) and electron microscope (EM) examination of the effects of methotrexate (MTX) on the endosalpinx.
Adverse reactions of titanium-based chemotherapeutic agents on male reproductive organs Possible role for human leukocyte antigen haplotypes in hepatotoxicity and/or pancreotoxicity associated with chemotherapy Novel Targeted Anticancer Prodrugs of Phosphoramide Mustard 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
12:00 Resistance - a Global Issue for
Cancer cell life-cycle: The mechanism of genotoxic resistance.
diverse therapeutic areas - Part I
Molecular Imaging of Multidrug Resistance Mediated by ABC Transporters in Osteosarcoma Insulin resistance: between myth and reality Mechanism of Resistance in Non Hodgkin’s Lymphoma- Expression of Fas Ligand on Endothelial Cells Lining Blood Vessels Battling pharmacoresistance in epilepsy patients: pharmacodynamic and pharmacokinetic approaches Aspirin Non-responders in Thai Ischemic Stroke/TIA Patients 12:00 Vaccines - Antiinfectives - HIV - Part
Using immune complexes to enhance antigenicity and immunogenicity of a neutralizing epitope on HIV-1 envelope gp120 Bait bullets controlling Bacillus anthracis: from spore inhibition to toxins neutralization and prevention of spore- and/or toxin-induced cell death.
Synthesis of a Novel Subunit Vaccine against HIV-1: Native Envelope Proteins in Lipid Bilayer of Inactivated Virions Devoid of p24, RT and Viral Nucleic Acids Current Medical Countermeasures (Vaccines- Antibodies- Antibiotics) to Protect Humans from the Anthrax Bioterrorism Interactions between the HIV-specific Immune Response and the Development of Resistance to Antiretroviral Drugs.
12:00 Vaccines - Development, production
Complex Carbohydrate-Based Cancer Vaccines: Magic Bullets in the Making? and manufacturing - Part II
Finding a New Vaccine in a Ricin Protein Fold Single-Chain Antibodies and Immunoconjugates: Computational and Functional approaches Enhanced depot vaccine formulations, VacciMax and DepoVax, for cancer and pandemic influenza applications 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
12:00 Antidepressant drugs and their
Dopamine transmission and the search for the ideal antidepressant drug mechanism of action - Part II
Magic Bullets for PET Brain Imaging of Antidepressants in Man Ocular Infections: Impact of Resistance to Fluoroquinolones and Other Antibiotics on Topical Therapies Emergence of colistin resistance during therapy of infections by multi-drug resistant gram negative pathogens in the critically ill 12:00 Antineoplastic agents - New targets
Targeting the Tumor Microenvironment as a Modality to Combat Cancer – Effect of & compounds - Part II
Jasmonates Kill Cancer Cells Selectively by Dissociating Hexokinase from Mitochondrial VDAC mTOR Inhibitors for Hepatocellular Cancer (HCC) - A moving Target - MicroRNA as a novel drug for cancer metastasis: Suppression of lung metastasis of osteosarcoma in in vivo model 12:00 Antineoplastic agents - Personalized
Prognostic value of total AgNOR area/Nucleus area per cell in urinary bladder therapy - Part II
carcinoma via two-dimensional image analysis COXEN: A New Strategy for Predicting the Chemosensitivity of Human Cancers and its Application to Drug Discovery Personalized Medicine - a Paradigm Shift in the Treatment of Cancer 12:00 Antivirals - New compounds and
Development of Highly Anti-HIV Active and Lowly Toxic 4’-C-Ethynyl-2’-deoxy-2- their mechanisms - Part I
fluoroadenosine and A Proposal of The Way to Develop Highly Active and Lowly Toxic Antiviral Modified Nucleosides Targeting HIV Reservoir & Sanctuary Sites Using Peptide Backbone Polyethylene Glycol (PEG) Nanocarriers Virostatics: a new class of immunomodulators (leading compound in Phase II) with dual antiviral and cytostatic properties to inhibit viruses and protect the immune system from hyperactivation during chronic infections Identification of Novel Hepatitis C Virus Polymerase NS5B Inhibitors Through Structure-Based Virtual Screening and 3-D QSAR Studies 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
12:00 Drug transporters and delivery - Part 1206 Ohtsuki
Reconstruction of In Vivo P-Glycoprotein Activity from In Vitro Information by Targeted Molecular Dynamics Simulations of human membrane transport proteins from the Major Facilitator Superfamily.
Hypothesis on the physiological significance of the expression of the drug transporters mdr1 and Abcg2 during normal tissue regeneration and after cancer therapy Delivery of specific targeted drugs into the cells by TAT-technology 12:00 Antineoplastic agents - Search and
A potential tumor cell-penetrating peptide, CRGDCF(K[H-]KKK)6, for the delivery of Development of new Magic Bullets -
Molecular strategies to improve the anti-tumour activity of Zoledronic acid in prostate cancer cells Thermally Targeted Delivery of Anticancer Peptides by Elastin-like Polypeptide 12:00 Vaccines - Antiinfectives - Bacteria
APPLIED REVERSE VACCINOLOGY: A MENINGOCOCCAL SEROGROUP B and parasites - Part II
12:00 Vaccines - Targeting non-infectious
diseases - Part II
12:00 Steroids, Receptors & pulmonary
Seretide:a revolution in the treatment of asthma and COPD diseases
Predicting optimal endocrine treatment for hormone-dependent breast cancer through the right bullets and targets Allosteric modulation of hormone receptors in cancer treatment Estrogen Receptor Beta may be a Novel Target for the Beneficial Effects of Estrogens in Females, and Androgens in Males, for Anxiety, Depression, and Cognitive Function Molecular prediction of the therapeutic response to neoadjuvant chemotherapy in breast cancer Cell-specific delivery of kinase inhibitors using lysozyme: A novel approach to treat renal fibrosis 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
12:00 Brain physiology, biochemistry, and
Treating the Untreatable: Alpha 1-Adrenoreceptor Antagonist Prazosin for PTSD, drugs acting on the brain - Part II
Disruptive Agitation in AD and Alcohol Dependence. PACAP signaling: a promising drug target for neuropsychological disorders A novel view of the pathophysiology of psychiatric disorders and development of pharmacotherapy based on brain energy metabolism How Prolonged Exposure to Caffeine Can Affect Dopaminergic Transmission: Evidence from Rats Subchronically Treated with Caffeine and Possible Implications 12:00 Antibacterials - PK/PD: past,
PK/PD in patients - Learning from our Failures presence, and future challenges
Changing the dosing frequency of ceftazidime transforms this “Daisy cutter” into an antibiotic with limited collateral damage while retaining its efficacy Pharmacometric Tools to Optimize Modeling and Control of Drug Therapy for Patient Care Decoding infections - How to use „administrative“ data for clinical quality improvement 13:00 Targets, Drugs and Carriers –
Sphingosin 1-phosphate signalling and therapeutic implications Approaches to Translational
Multivalency as action principle for the suppression of inflammatory processes Medicine
Glycosidic Phospholipids: Inhibitors of cell proliferation and migration Financial support: German Research
Inhibitors of secreted aspartic proteinases for the treatment and prevention of Foundation (FG463)
Targeting of blood vessels by small ApoE-like peptides From fundamental research in carrier-related skin penetration to polymerase-alpha inhibitors for skin tumor therapy 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Antineoplastic agents - Factors
UNEXPECTED EFFECTS ON ANGIOGENESIS BY TYPE OF LOW-MOLECULAR- affecting cancer and cancer
WEIGHT HEPARIN AND BY TYPE OF VEHICLE IN CHEMOTHERAPY chemotherapy - Part II
Interfere IGF-I pathways to augment sensitivities of colorectal cancer cells to current therapeutic agents Inhibition of Tumor Metastasis and Angiogenesis by NK4, Bifunctional Inhibitor of HGF-Met and Angiogenesis.
CYP1A1, GST Gene Polymorphisms and Risk of Chronic Myeloid Leukaemia The effects of cytochrome P450 enzyme polymorphisms on bladder cancer and prostate cancer Distinct cell cycle proteins control Schwann cell proliferation in health and disease The Role of Heat Shock Proteins in Oral Cancer: A Possible New Target in Antineoplastic Therapy? 14:00 Treatment of diseases with
Cancer Immunotherapy with Adenovirus-IFNg (TG1042).
involvement of the immune system -
Part III
Role of antiproliferative enzyme indoleamine (2,3)-dioxygenase in the impaired immune function in infectious diseases INTRAVENOUS IMMUNOGLOBULIN THERAPY TARGETING MUTLIPLE BULLET HOLES.
Hormone-immunotherapy significantly prolongs clinical benefit and median overall survival of metastatic endocrine dependent breast cancer patients 14:00 Immunosuppressants - Part II
Is Cyclosporine the magic bullet in dermatology? Efficacy of 1% topical cyclosporine in the treatment of severe vernal keratoconjunctivitis in childhood Nephrotoxicity of immunosuppressive drugs : New insights 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Antineoplastic agents - New
strategies and new compounds- Part
II
Antineoplaston: Synthesis, Biology, and Clinical Evaluation in Egypt New Anti-Cancer Peptides that Cause Lysis and Necrosis of Tumor Cells but Have No Effect on Normal Cells Anticancer gold compounds: mechanistic insights 14:00 Antineoplastic agents - Compounds
Recombinant Immunotoxins for the Treatment of Cancer and approaches - Part III
Heparin as an inhibitor of cancer progression; the role of selectins Vascular disruption: an old mechanism rediscovered for targeting tumor blood supply Cancer stem cells - towards a new generation of antineoplastic drugs Synergistic Action of Resveratrol and its Polyhydroxylated Derivative with Cytarabine in HL-60 Human Promyelocytic Leukemia Cells 14:00 Vaccines - Development, production
Adjuvant Systems for Vaccines Targeting Unmet Needs: From Concept To Clinical and manufacturing - Part III
Challenges and potential solutions to innovative vaccine development in developing countries Antibody polyreactivity and ill-defined levels of antigen mimicry hamper the search for effective peptide-based vaccine immunogens RABIES IN BATS AND PROTECTIVE TREATMENTS OF HUMANS IN EUROPE 14:00 Mechanisms of inflammation and
Advent of pharmacology of nociceptors initiated by capsaicin has opened also a new anti-inflammatory agents - Part II
Orally Ingested Lactoferrin and Glycine Display in vivo Synergistic Anti-Inflammatory Activity INSULIN SUPPRESSES HIGH MOBILITY GROUP-B1 (HMG-B1) PROTEIN AND TOLL LIKE RECEPTOR EXPRESSION: FURTHER EVIDENCE OF ITS ANTI-INFLAMMATORY EFFECT 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Antineoplastic agents - Creating
Trabectedin: A new anticancer bullet from the sea Magic Bullets from natural
compounds - Part I
Discovery & Development of Antineoplastic Magic Bullets from Natural Products Retinoic acid regulates the expression of the anti-apoptotic protein PKCdeltaVIII.
Chemopreventive and cellular protective effects of Resveratrol and EGCG in human and animal cancer models.
The differential dose-dependence for pro-angiogenic and cytotoxical effects of new anticancer plant agent within different nanocarrier formulations.
Magic Bullets from Ethnobotanical Sources: Challenges and Concerns 14:00 Antineoplastic agents - New
ANTI-ANGIOGENIC AND ANTI-NEOPLASTIC POTENTIAL OF PROSTATE- approaches to antineoplastic
therapy and cell survival - Part II
Oral cancer: molecular pathogenesis and novel therapeutic approach Targeting cancer through PI3K by the bGBP cytokine and induction of apoptosis by the activation of alternative pathways.
Is GRP78/BiP, a Master-Regulator of Defensive Unfolded Protein Response, a New “Magic Target”? GRP78/BiP-targeting Cytotoxin and ER Stress-Inducing Drugs Synergize to Kill Cancer Cells Heparin as anti-inflammatory and anti-metastatic drug- new potentials of an old player 14:00 Antineoplastic agents - Old and new
Arsenic Trioxide induces apoptosis preferentially in B-CLL cells of patients with compounds / approaches - Part I
unfavorable prognostic factors including del17p13 Phage Display: Opportunities for Development of Personalized Anti-Cancer Therapeutics Chemotherapeutic agents for Merkel cell carcinoma - past, present and future Cell Penetrating Antibody Delivery to Intracellular Targets 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Antiparasitic compounds - Magic
Sulfadoxine- Pyrimethamine: Dead or alive for malaria control? Bullets to treat malaria
Vitamin utilisation pathways as antimalarial drug targets Structure and Antimalarial Activity of Immunomodulator P-MAPA Bis(2-aminoimidazolinium)diphenyl Compounds as DNA Minor Groove Binders with in Vivo Antitrypanosomal and Antimalarial Activity: the cation is important 14:00 Pharmaceutics - Drug delivery - Part
On the Delivery of Carmustine, Paclitaxel, and Etanidazole to Brain Tumors: An integrated study on the novel fabrication methods of pharmaceutical particles and 3-D computer simulations for chemotherapy and radiotherapy applications Study of Tenoxicam on Various Drug Delivery Systems Transdermal Drug Delivery into and beneath the skin - Application to Analgesics and Anti Inflammatory Drugs 14:00 Antivirals - Mechanisms and
Synthesis, Anti-rhinovirus Activity and Mechanism of Action of New Chromene and development of antivirals - Part II
Combinational therapeutics Targeting Laboratory and Clinical Isolates of HIV-1 Epidemiology of Highly Pathogenic Avian Influenza Outbreaks in Bangladesh Antiviral chemotherapy in HTLV-1 infection: Highlights from in vitro studies 14:00 Nerve diseases, mechanisms, and
Glucose Transporter Type 2 - Does It Pave the Way to Sporadic Alzheimer's Disease? pathophysiology - Part II
Proline specific peptidases as a new targets for drug development. Pharmacology and Pathophysiology The Role of PPAR gamma Agonist in Alzheimer’s disease 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Drug-drug and drug-nutrient
Advantages of Multiple Drug Interactions: Combinatorial Treatments Using Neural interactions - Part I
Pharmacokinetic and pharmacodynamic interactions between mepivacaine and antihypertensive drugs Natural products from plants and its derivatives as CYP19 (aromatase) inhibitors: flavonoids and dihydroisocoumarin Factors that influence the prevalence of drug-drug interactions between antiretroviral drugs in a healthcare sector in South Africa Let food be thy medicine and medicine be thy food 14:00 Bioanalytics - The cutting edge of LC- 10000 Sauber
Microfluidics-driven HPLC-Chip / Triple Quadrupole Mass spectrometry - shattering MS/MS - Part II
the sensitivity barrier for small animal pharmacokinetic studies iTRAQ-coupled 2D LC-MS/MS Analysis of Proteomics Profile in Cells Incubated with S- or R-enantiomers of Chiral Drugs: from Metabolic Pathways to Biomarker Discovery The Role of Metabolism, Pharmacokinetics and Mass Spectrometry in Selection of a Thrombin Receptor Antagonist for Development LC-MS/(MS) strategies for increased metabolite coverage in metabolomics LC-MS/MS shotgun proteomics of lung cancer pleural effusions identifies the prognostically relevant epithelial-mesenchymal transition protein periostin 14:00 Pharmaceutics - Drug delivery - Part
Bioconjugated Cytotoxin Prodrugs and Imaging Agents in Anticancer Research Magnetic Resonance Imaging ‘Pathfinder’ Molecules For Use in Optimizing Antibody and Gene-Directed Enzyme-Prodrug Therapy (ADEPT/GDEPT) Treatments Corpora non agunt nisi fixata: tailored drug targeting by intelligent active principles or intelligent transporters, state of art and our experience Recombinant Gas Vesicles: A Novel Display/Delivery System For Peptide Antigens (SIV) Targeted and Multifunctional Dendritic Polymers: Magic Bullets for Drug and Gene Delivery 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Therapeutic Proteins - discovery
Biopharmaceuticals in Plants; Toward the Next Century of Medicine and manufacturing - Part II
The Critical Functions of Biliverdin Reductase (BVR) in Insulin/Insulin Growth Factor-1 (IGF-1) and MAPK Signaling Pathways: A Potential Therapeutic Application in Treatment of Diabetes and Cancer Recombinant therapeutic proteins - - - from the viewpoint of a biotechnologist Spider silk proteins - the next generation of bioimplantable materials. Biochemical structure and mechanical function 14:00 Antibacterials - The rise of
Antibiotic resistance: what we can learn from evolution? antibacterial resistance
Molecular Characterization of Antibiotic Resistance in Selected Enteropathogens Isolated from Raw Food Samples in Vietnam Pathophysiological Approach against Resistant Bacteria-causing Infectious Diseases; - from Autopsy Findings to Clinical Applications Antimicrobial Resistance by Mycoplasma species in Farm Animals.
National Surveillance of Antibiotic Resistance in Iran The impact of antimicrobial drug use and the use of alcohol-based hand rub on the emergence and spread of extended-spectrum ß-lactamase (ESBL)-producing strains - A time series analysis 14:00 Blood brain barrier physiology and
Molecular Changes Induced by Stress Factors in Cerebral Endothelial Cells diseases - Part II
Breaching the Barriers of the Brain: from physics to cures Effects of Intracarotid Injection of Methylprednisolone on Cellular Oedema after Osmotic Opening of the Blood-Brain Barrier in Rats The impact of interferon-? treatment on the blood-brain barrier 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Antineoplastic agents - Approaches
Optimizing therapy by platinum compounds via PK/PD to optimize therapy - Part II
Predicting the active doses of new anticancer agents in humans directly from preclinical data Nanomedicines - Self Nanoemulsifying Drug Delivery System (SNEDDS) and Nanosuspension for Oral and Parenteral Formulations in Cancer Therapy with Significant Impacts on Pharmacokinetics and Biodistributions Targeted Therapy of Human Neuroblastoma Cells using Auger Electrons of Indium-111-labeled N-myc Antisense Oligonucleotide Which ABC-transporters should we target in leukemia? Synergistic or Antagonistic Interaction between Taxanes and G1/S Arresting Agents in Combination Therapy Personalized anticancer therapy – impact of biomarkers Search for a novel biomarker for the malignant brain tumor Glioblastoma Multiforme 14:00 Psychoactive drugs - Part I
Ketanserin and dexfenfluramine: angels or demons for serotoninergic 5-HT2 receptors ? PSYCHOTOMIMETIC ACTION OF KETAMINE AND MK-801: BEHAVIORAL, NETWORK AND CELLULAR FEATURES Feasibility of Mapping Brain pH Using 31P MR Spectroscopy Neurodevelopment of Children Following Exposure to Psychotropic Medications During Gestation: a Novel Approach to Behavioral Teratology Nicotinic acetylcholine receptor containing an alpha6 subunit: target for a magic bullet? Substance Use and Its Functions, Dysfunctions, and Alternative Functions in Contemporary Society Neuropeptides in Stress-Related Disorders: Possible Interaction of Vasopressin and Corticotropin Releasing Hormone Pharmacogenetic diagnostics for optimization of psychotropic drug treatment 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
14:00 Erythropoietin - a Magic Bullet's quo
Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietic Stimulating Proteins - What is the Optimal, Safe Hemoglobin Target? Erythropoietin in Cancer Anaemia: Friend or Foe? Erythropoietin-binding protein and Its Antibodies For Possible Clinical Application ERYTHROPOIETIN: BOLD DIRECTIONS AND STRATEGIES FOR A MAGIC BULLET DESTINED FOR NEUROVASCULAR DISEASE Erythropoiesis-stimulating agents may improve survival in low-risk MDS patients 14:00 Antivirals - General issues and their
Aciclovir- a nearly atoxic antiviral drug with severe neurotoxic side effects. A solutions - Part II
retrospective review of 280 cases and the importance of analysing the aciclovir metabolite CMMG Principal parallels between Interferon type I- and small inhibitory (si)RNA- based therapies Present knowledge on pharmacogenetics of antiretrovirals ROCA B The impact of highly active antiretroviral therapy on cytomegalovirus retinitis: triumphs and future challenges Clinical importance of drug resistance in antiviral therapy for Hepatitis B Infection Rapid intervention: the role of antivirals in containing or controlling pandemic influenza Bilirubin: an Endogenous Molecule with Antiviral Activity in vitro 16:45 Nerve diseases, mechanisms, and
A Novel Polymorphic Purine Complex at the 1.5 kb Upstream Region of the Human pathophysiology - Part III
Caveolin-1 Gene and Risk of Alzheimer¢s Disease; Extra-Short Alleles and Accumulated Allele Homozygosity Neurotoxicity Related to Lithium Combination Treatment in a Patient with Schizoaffective Disorder Blood-brain barrier P-glycoprotein function in aging and neurological disease: in vivo measurements in humans with [11C]-verapamil PET Innovative nanopharmaceutical strategies for neuronal survival and regeneration after traumatic brain injury 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
16:45 Antineoplastic agents - Clinical trials
Treatment strategies for multiple liver metastases from colorectal cancer and approaches- Part II
Teaching an old dog new tricks: Intralesional Bleomycin Injection (IBI) Treatment of Vascular Birthmarks Intrapericardial Cisplatin Treatment Prevents Effectively the Recurrence of Neoplastic Pericardial Effusion.
Systems-directed targeted therapies in metastatic tumors: Equitable to reductionist therapy approaches? Correlation between clinicoprognostical features and allelic loss at TP53 in metastatic endometrial cancer 16:45 Antineoplastic agents -
The insulin-like growth factor pathway- the key to overcoming resistance in cancer Effectiveness and resistance in
patients - Part III
16:45 Antineoplastic agents - Biochemical
Methotrexate induces permanent growth arrest in human adenocarcinoma cells.
approaches
"Rational design of specific inhibitors of g-glutamyl transpeptidase (GGT) and g-glutamylcysteine synthetase (GCS) for modulating cellular glutathione and redox status" Mechanism of Oxidative DNA Damage and Apoptosis Induced by Doxorubicin through Generation of Reactive Oxygen Species Citrate transport mechanism in prostate and its changes in malignant transformation. Implications for fatty acid synthesis in cancer The cytostatic treatment effect on nucleoli of leukaemia cells at the single cell level 16:45 Antineoplastic agents - Tyrosine
EARLY RESULTS OF IMATINIB AS THE ACTIVE AGENT IN CONTROL OF Kinase Inhibitors - Part II
AGGRESSIVE FIBROMATOSIS. An Attempt of Metaanalysis.
Receptor protein tyrosine phosphatase beta/zeta as a possible new target to regulate endothelial and tumour cell migration In vitro hypothesis, in vivo veritas. Success and failure of Imatinib in cancer target therapy 2nd World Conference on Magic Bullets - Ehrlich II Time Session
FINAL TITLE
16:45 Treatment of severe infections
What we have learned in recent years in the therapy of life threatening including sepsis
Current systemic and local therapies of intra-abdominal sepsis Bone marrow stromal cells attenuate sepsis and sepsis-induced acute kidney injury (AKI) via a novel mechanism of action.
New anti-endotoxins agents againts gram-negative bacteria infections 16:45 Steroid receptor - Jensen
Steroid Sulfatase Inhibitors – Novel Therapeutic Agents for Hormone Dependent symposium
A Role for Macroautophagy in Antiestrogen Resistance Mechanisms that Explain the Lower Incidence of Breast Cancer in Postmenopausal Women Treated with Conjugated Estrogens (CEE). Role of Estrogen Receptor a and b.
Competing Causes of Death from a Randomized Trial of Extended Adjuvant Endocrine Therapy for Breast Cancer: NCIC CTG MA.17 New Steroidal Hormones Promise to Become a Multi-Purpose “Magic Bullet” 16:45 Therapy with monoclonal antibodies - 394
Lumiliximab, a novel therapeutic agent for the treatment of Chronic Lymphocytic First-line treatment with Rituximab combined with intravenous or oral Fludarabine for patients with extranodal Mucosa Associated Lymphoid Tissue (MALT) lymphoma.
Blockade of IL-6 signalling with a humanized anti-IL-6 receptor antibody, tocilizumab, for the treatment of rheumatoid arthritis New Medicines, New Problems: Understanding the failure of the phase I clinical trial of monoclonal antibodyTGN1412 Infliximab: Beyond the primary expectatives 16:45 Cytochrome P450 drug metabolism
New Substrates for the Major Drug Metabolising Cytochrome P450 Enzymes

Source: http://www.ehrlich2007.org/All_Oral_Presentations.pdf