Benazecare flavour

Animalcare Limited
Common Road
York YO19 5RU
Tel: +44 (0) 1904 487687 Fax: +44 (0) 1904 487611
On rare occasions, transient signs of hypotension, such as lethargy and ataxia may occur, especially at Presentation
tablets. Each tablet contains 20mg benazepril hydro- As is routine in cases of chronic renal insufficiency, it is recommended to monitor plasma creatinine and After oral administration, benazepril is rapidly absorbed from the gastrointestinal tract and hydro- Do not use in pregnant or nursing bitches, or in lysed into benazeprilat, a highly specific and potent bitches intended for breeding. Studies in laboratory inhibitor of angiotensin converting enzyme (ACE).
animals (rats) have shown embryotoxic effects of Benazeprilat produces significant inhibition of plasma benazepril at non-maternotoxic doses (urinary tract ACE activity for more than 24 hours after a single abnormalities in the foetus). The safety of the product dose in dogs. Inhibition of ACE leads to a reduced has not been assessed during pregnancy and lacta- conversion of inactive angiotensin I into angiotensin II and therefore reduction in the effects mediated by Laboratory studies in rats and observations in angiotensin II, including vasoconstriction of both humans have produced evidence of teratogenic ef- arteries and veins, retention of sodium and water by the kidney and remodelling effects (including patho- In dogs with heart failure, benazepril has been given in combination with digoxin, diuretics and anti- In dogs with heart failure, benazeprilat lowers the arrhythmic drugs without demonstrable adverse in- blood pressure and volume loading effect on the heart. Onset of clinical efficacy can be expected In healthy dogs overdose up to 200-fold was approximately 1 week after initiation of treatment asymptomatic. Transient reversible hypotension may with benazepril hydrochloride. Benazeprilat is ex- occur in cases of accidental overdose. Symptomatic creted equally by both biliary and urinary routes in treatment should consist of intravenous infusion of dogs and therefore no adjustment of the dose of the product is necessary in the treatment of cases with In man, the combination of ACE inhibitors and NSAIDs can lead to reduced anti-hypertensive effi-cacy or impaired renal function. The combination of Dosage and administration
benazepril and other anti-hypertensive agents (e.g.
is 0.25 mg benazepril hydrochloride/kg body weight, calcium channel blockers, b-blockers or diuretics), to be given orally once daily. The dose may be anaesthetics or sedatives may lead to additive hypo- doubled, still administered once daily, if judged tensive effects. Therefore concurrent use of NSAIDs clinically necessary and advised by the veterinary or other medications with a hypotensive effect should surgeon. The dosing regime is as follows: be considered with care. Renal function and signs of BENAZECARE 20mg
hypotension (lethargy, weakness etc) should be mon- Weight (kg)
Standard dose
Double dose
itored closely and treated as necessary.
Interactions with potassium preserving diuretics like spironolactone, triamterene or amiloride cannot be ruled out. It is recommended to monitor plasmapotassium levels when using benazepril in combina- Benazecare can be given with or without food. The tion with a potassium sparing diuretic as life threat- Benazepril may be given with digoxin, diuretics and Contra-indications, warnings, etc
cial care to avoid accidental exposure because ACE inhibitors have been found to affect the unborn child Do not use in any dog that has evidence of cardiac output failure, for example, due to aortic stenosis.
In case of accidental ingestion by children, seek Do not use in cases of known hypersensitivity to medical advice immediately and show this label to the active substance or to any of the excipients.
Pharmaceutical precautions
Packaging Quantities
taining 14 tablets packed in a cardboard box with a package leaflet. Benazecare Flavour 20mg tablets are supplied in packs of 14, 28, 56 or 140 tablets. Not all Return any halved tablet to the blister pack and use Keep the blister pack in the outer carton.
Further information
Do not use after the expiry date stated on the benazepril has been observed in dogs during clinical trials. The biliary excretion of benazepril means there is little risk of bioaccumulation in dogs with impaired should be disposed of in accordance with national


Forensic & industrial science ltd

Estimating actual yield in clandestine laboratory syntheses of methamphetamine Nicholas G. Powel Forensic & Industrial Science LimitedP Box 67-087Mt Eden Auckland 1003 New [email protected] introduction This paper discusses the topic of yield and examines specifically the assumptions that underpin drug yield estimation methods currently used for forensic purposes in

Microsoft word - reussir en pologne_info.doc

La Chambre de Commerce et d’Industrie Française en Pologne vous invite à son premier séminaire virtuel dédié au marché polonais et à ses opportunités d’affaires. Réussir en Pologne - séminaire virtuel (webcast) mercredi 16 mai 2012 de 10h à 11h45 Le séminaire s’adresse à tous les représentants d’entreprises françaises souhaitant développer leur activité et chercha

Copyright © 2010 Health Drug Pdf