• Operative mortality 0.2 per cent• Most common cause of death was sepsis
• 77% of patients had significant pre-existing
• Defined as those requiring transfusion• Intraoperative bleeding - 2.5 %• Postoperative bleeding 3.7 %• Average blood loss 250 - 400 mls• Bleeding related to size of gland and length
of surgery ie greater than 90 min ( 7.3% vs 0.9% ) and greater than 45 gms ( 10% vs 0.9 % )
• Arterial bleeding a problem - requires
surgical correction at the time or take back
• Venous bleeding difficult to stop surgically
occurs at the end of the procedure and due to venous sinuses being opened
• Can be controlled by catheter traction
• Inflate balloon to 50 ccs• Ten minutes at a time• Can be left on continuous traction for up to 24 Hrs.
• In some circumstances - especially after
resection of prostatic carcinoma - can get DIC - use of Amicar ( Epsilom amino caproic acid )
• Must make sure complete evacuation of clot
• Rise in patients BP, decrease in pulse,
• Can lead to cardiac arrythmias and death• Due to dilutional hyponatremia• Related to:
– Size of gland 45 gms ( 1.5 vs 0.8 )– Resection time 90 min ( 2 % vs 0.7 % )– Surgical experience - deep exposure of capsule
• Usually do not become symptomatic until
• Generally corrected with N saline and lasix
sometimes have to give hypertonic 2N or 3 N Saline plus lasix ( must be accompanied by a diuretic to avoid pulmonary odema )
• Post operative incontinence occurs in 1.7 %
of patients with 0.4% having total incontinence
• Source of many malpractice suits• 2 sphincter mechanism internal and external
• Internal Sphincter always removed• External Sphincter controls continence ( at level of
• Three things are important in post operative
– Sphincteric injury– Detrusor Instability– Residual obstruction which impairs external
• Rely on internal Sphincter and Distal
sphincter may become lax - Pelvic floor exercises
• If patients remain incontinent after a few
– Urodynamics - diagnose instability / Genuine
Stress incontinence / bladder outlet obstruction
– Cystoscopy to look at obstructing apical
• Incontinence persists for 1 year options:-
• AUS• Contagen or macroplasique• ? Protrac device
• 6.5 % of patients fail to void after TURP• 50% of these have hypotonic bladder• Risk factors for hypotonic bladder:-
• Painless urinary retention vs painful retention• Long history of prostatism• Neuropathic bladder ie diabetics• Known high residuals
• Cannot predict which patients will void
• If fail to void after surgery need to perform
Urdynamics ( Hypocontractile vs Obstructed )
• Better to leave SPC on free drainage to give
bladder a chance to recover then repeat Urodynamics - if no return of function leave SPC on Staubli valve or teach ICSC
• Consider patients voiding successfully even if
have high residual as long as they are free of infection and void with low bladder pressure
• Variously quoted 4 - 40 %• Due to nerve injury by current leak to
• Retrograde ejaculation in 100 % of men
• Incidence about 2.7 %]• Why ? Small glands which have bladder
neck hypertrophy ? Over coagulation at bladder neck region ?
procedure, consider a bladder neck incision
• In some instances all you need in BNI ( 6 0’
• Incidence 2.5 %• Related to the length of time IDC in before
• After TURP most important cause is trauma
• Most common site is external urinary
• Preoperative UTI was found in 11 % of
• Postoperative rate of 2.3 %• Role of prophylactic antibiotics remains
induction and oral antibiotics given until 3 days after catheter removal. Take catheter out early
– Closed catheter drainage system– Use of pumps to break up clot rather than
– Take catheter out as soon as possible
• Pyuria and microscopic haematuria can
• Can get secondary bleed 10-14 days post op - as long
as you can void generally settles by 24-48 hours
• Avoid Constipation. 1 tsp nulax nocte straining--->
• Need 6 weeks off work• Sexual activity after 6 weeks• Gradual physical activity to normal by 6 weeks• Drive car at 6 weeks ( sit on prostate )• Wont be happy with waterworks for up to three
• First symptom to improve is the flow rate, then
daytime frequency will improve finally nocturia will improve but may take 6 months
• Penile tip pain after voiding common until
• Flow rate may decrease from that immediately
• Recommence NSAID or aspirin after 4 weeks
• Stopping Aspirin before operation• Length of time to stop aspirin preop• Use of Calciparine and Calf compressors
SYNOPSIS OF BIOCHEMISTRY COURSES OFFERED IN THE DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY BCH 201: GENERAL BIOCHEMISTRY I (2 UNITS) L:2 T:0 P:0 Principles of the chemical basis of life. The molecular basis of cellular structure – polysaccharides, lipids, proteins, nucleic acids. The cellular basis of life. Buffers, Acidity and alkalinity; pH and pKa values and their effects on cell
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