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Hypertension and microalbuminuria in hiv infected patients: beneficial effects of the treatment with telmisartan
Ucciferri et al. Retrovirology 2010, 7(Suppl 1):P64http://www.retrovirology.com/content/7/S1/P64
Hypertension and microalbuminuria in HIVinfected patients: beneficial effects of thetreatment with telmisartan
Claudio Ucciferri*, Paola Mancino, Katia Falasca, Francesca Vignale, Jacopo Vecchiet
From 16th International Symposium on HIV and Emerging Infectious DiseasesMarseille, France. 24-26 March 2010
statistically decreased at T1 (p = 0,006) and further on
In HIV infected patients there is increasing evidence of
T6 (p = 0,0001), whereas MDRD-GFR was statistically
hypertension and microalbuminuria, two important risk
augmented (p = 0,03). Cystatin-C, endothelin-1 and
factors for renal and cardiovascular disease (CVD). Anti-
VEGF were statistically reduced at T3 (p = 0,0001; p =
hypertensive drugs inhibiting the renin-angiotensin sys-
0,01 and p = 0,0045 respectively) and at T6. TG, TCh,
tem exert an antiproteinuric effect. Telmisartan, an
LDL-C levels decreased with statistical significance at
angiotensin II receptor blocker partial agonist of the
T6 (p = 0,003; p = 0,03 and p = 0,02 respectively), while
PPAR-g approved for the treatment of hypertension,
HDL-C increased at T6 (p = 0,04). ESR, PCR and IL-18
seems to exert a nephro-protective effect independent of
decreased at T6 (p = 0,04; p = 0,006 and p = 0,02
blood pressure reduction in the general population. Aim
of the study was to evaluate kidney-protective effects oftelmisartan
Telmisartan was well tolerated and effective to improvehypertension and lipid metabolism. Decreased microal-
buminuria and cystatin-C with increased MDRD-GFR
8 Caucasian male HIV+ patients cART treated without
are indicative of nephro-protective effects of telmisartan.
therapeutic changes for over 12 months and recent diag-
Mechanisms causing microalbuminuria in HIV+ patients
nosis of mild hypertension, were treated with telmisar-
could be related to infection, chronic inflammation and
tan 80 mg daily. They had suppressed viremia and CD4
endothelial dysfunction. Decreased endothelin-1 and
cell count > 300 cell/ml up on 6 month, and microalbu-
VEGF in this study may be related to an endothelial
minuria >5 mg/l. Systolic (SBP) and diastolic (DBP)
protective effect of telmisartan. These data confirm
blood pressure, triglycerides (TGs), total cholesterol
renal and endothelial protective effects of telmisartan
(TCh), HDL (HDL-C) and LDL (LDL-C) cholesterol,
CRP, ESR, microalbuminuria, MDRD-GFR, cystatin-C,IL-18, VEGF and endothelin-1 were measured at base-
line (T0), one (T1), three (T3) and six months (T6). Allthe statistical analysis was performed with the SPSSAdvanced Statistical 7.5 Software.
doi:10.1186/1742-4690-7-S1-P64Cite this article as: Ucciferri et al.: Hypertension and microalbuminuria
in HIV infected patients: beneficial effects of the treatment with
Treatment with telmisartan improved SBP and DBP
telmisartan. Retrovirology 2010 7(Suppl 1):P64.
values at T1 yet (p = 0,001). Microalbuminuria were
* Correspondence: Infectious Disease Clinic, Department of Medicine and Science of Aging, “G.
d’Annunzio” University, Chieti, Italy
2010 Ucciferri et al; licensee BioMed Central Ltd.
HS2 – Impacts on historic and natural environment Map 5: Potter Row In this section the HS2 route will run along to top of the hills to the east of Great Missenden through a farmland landscape, though the line will be in a cutting for most of this section • The line cuts through Sibley’s Coppice (ancient woodland), arable fields, hedgerows and properties beside Frith Hill Lane
RECURRENT APHTHOUS STOMATITIS (Recurrent Mouth Ulcers) What are the aims of this leaflet? This leaflet has been written to help you understand more about Recurrent Aphthous Stomatitis (RAS). It tells you what it is, what causes it, what can be done about it and where you can find out more about it. What is recurrent aphthous stomatitis (RAS)? RAS consists of recurrent bouts of one