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CURRICULUM VITAE Name: António Braz da Silva Parreira Qualifications: Diploma in Medicine - Lisbon University School of Medicine - 1972. Haematology Board Certificate - Lisbon University School of Medicine, Santa Maria Hospital - 1979. PhD in Haematology - Lisbon University School of Medicine - 1989. Positions held: Junior Assistant of Pharmacology - 1969-72. Internship in Internal Medicine - 1973-74. Resident in Internal Medicine, Santa Maria Hospital - 1975-76. Resident in Haematology, Henri Mondor Hospital, Creteil, France, supported by a grant from the French Government - 1977. Resident in Clinical Haematology, Santa Maria Hospital, Lisbon 1977-80. Consultant of Clinical Haematology, Santa Maria Hospital, Lisbon - since 1981-90. Research Fellow at the Leukaemia Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, supported by a grant from the Gulbenkian Foundation - 1983-85. Assistant Professor of Immunology, Lisbon University School of Medicine, 1985-1989. Consultant of Clinical Haematology, Portuguese Institute of Cancer, Lisbon, 1990. Associate Professor of Haematology, Lisbon University School of Medicine, 1989-1992. Present Appointment: Head of Department of Clinical Haematology and the Hemato-Oncology Reseach Unit, Instituto Português de Oncologia, Lisbon, since 1992. Professor of Hematology Faculdade Ciencias Medicas, Universidade Nova de Lisboa, since 1996. Member of the following Scientific Societies: Sociedade das Ciências Médicas de Lisboa Sociedade Portuguesa de Hematologia Association Espanola de Hematologia y Hemoterapia The European Society for Medical Oncology The International Society of Hematology American Society of Hematology Selected Publications: Configuration of immunoglobulin and T-cell receptor ß and g genes in acute myeloid leukemia: pitffals in the analysis of 40 cases. Parreira L, Carvalho C, Moura H, Melo A, Santos P, Guimaraes JE, Parreira A. Journal of Clinical Pathology, 45;193-200, 1992. Splenic lymphoma with villous lymphocytes in two sisters. I. Ribeiro, M.M. Costa, B.A. Fernandes, I. Sousa, A. Melo, A. Parreira, L. Sousa Uva. Journal of Clinical Pathology, 45;1111-1113, 1992. Myositis with tretinoin [letter] Miranda N, Oliveira P, Frade MJ, Melo J, Marques MS, Parreira A. Lancet 344: 1096, 1994. Differential expression of cell adhesion molecules in the functional compartments of lymph-nodes and tonsils. R.P. Leite, M. Carmo-Fonseca, J. Cabeçadas, A. Parreira, L. Parreira. Journal of Clinical Pathology: Molecular 48:M93-M100, 1995. Natural Killer cell numbers and activity in mobilized peripheral blood stem cell grafts: Conditions for in vitro expansion. Silva MR, Parreira A, Ascensao JL. Experimental Hematology 23:1676-1681, 1995. HTLV tax gene expression in patients with lymphoproliferative disorders. Cardoso EA, Miranda N, Gameiro P, Frade MJ, Figueiredo M, Parreira A. Journal of Clinical Pathology 49:11 938J. 1996. Large-Volume leukaphereses may be more efficient than standard-volume leukaphereses for collection of peripheral blood progenitor cells. Passos-Coelho JL, Machado MA, Lucio P, Leal-da-Costa F, da Silva MG, Parreira A. Journal of Hematotherapy 6:465-474, 1997 Expression of adhesion molecules on chronic B-cell lymphoproliferative disorders. Lucio P, Faria T, Pinto A, Silva MRG, Junior E, Marques da Costa R, Parreira A. Haematologica 83: 104-111, 1998. Flow cytometric analysis of normal B-cell differentiation: a frame of reference for the detection of minimal residual disease in precursor B-ALL patients. Lucio P, Parreira A, van den Beemd MWM, van Lochem EG, van Wering ER, Baars E, Porwit-MacDonald A, Bjorklund E, Gaipa G, Biondi A, Orfao A, van Dongen JJM, San Miguel JF. Leukemia, 13; 419-27, 1999. The Nuclear Topography of ABL, BCR, PML and RARa Genes: Evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. H. Neves, C. Ramos, M Gomes da Silva, A. Parreira, L. Parreira. Blood, 4;1197-1207, 1999. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in Acute Leukemia for detection of Minimal Residual Disease – Report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in Acute Leukemia. JJM van Dongen, EA MacIntyre, E Delabesse, JA Gabert, G Canniza, G Saglio, E Gottardi, A Rambaldi, P Dotti, F Griesinger, A Parreira, P Gameiro, M Gonzalez Diaz, M Malec, AW Langerak, JF San Miguel, A Biondi. Leukemia 13:1901-1928 1999 CD123hi Dendritic Cell Lymphoma: An unusual case of Non-Hodgkin Lymphoma (NHL). P Lúcio, A Parreira, A Orfao. Annals Int Med 131(7):549-550, 1999. Flow cytometric characterization of CD7+ cell subsets in normal bone marrow as a basis for the diagnosis and follow up of T cell acute lymphoblastic leukemia ((T-ALL). A Porwit-MacDonald, E Bjorklund, P Lúcio, EG van Lochem, J Mazur, A Parreira, MWM van den Beemd, ER van Wering, E Baars, G Gaipa, A Biondi, J Ciudad, JJM van Dongen, JF San Miguel, A Orfao. Leukemia 14:816-825, 2000 High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H. Dearden CE, Matutes E, Cazin B, Tjonnfjord GE, Parreira A, Nomdedeu B, Leoni P, Clark FJ, Radia D, Rassam SM, Roques T, Ketterer N, Brito-Babapulle V, Dyer MJ, Catovsky D. Blood Sep 15;98(6):1721-6, 2001 BIOMED-I concerted action report: flow cytometric immunophenotyping of precursor B-ALL with standardized triple-stainings. BIOMED-1 Concerted Action Investigation of Minimal Residual Disease in Acute Leukemia: International Standardization and Clinical Evaluation. Lucio P, Gaipa G, van Lochem EG, van Wering ER, Porwit-MacDonald A, Faria T, Bjorklund E, Biondi A, van den Beemd MW, Baars E, Vidriales B, Parreira A, van Dongen JJ, San Miguel JF, Orfao A. Leukemia. Aug;15(8):1185-92, 2001 The PML-RARa transcript in long-term follow-up of acute promyelocytic leukemia patients. Gameiro P, Vieira S, Carrara P, Silva AL, Diamond J, de Sousa AB, Mehta AB, Prentice HG, Guimaraes JE, Hoffbrand AV, Foroni L, Parreira A.Haematologica Jun;86(6):577-85, 2001 Autologous peripheral stem cell transplantation for multiple myeloma in a patient with a 10 year-old kidney transplant: case report and clinical issues. Rego F, Alcantara P, Buinho F, Araujo F, Santos JM, Parreira A, da Costa FL.Transplant Proc. 2003 May;35(3):1102-4. Clonality analysis for antigen receptor genes: preliminary results from the Biomed-2 concerted action PL 96-3936. van Krieken JH, Langerak AW, San Miguel JF, Parreira A, Smith JL, Morgan GM, Kneba M, Macintyre EA, van Dongen JJ. Hum Pathol. 2003 Apr;34(4):359-61

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