CURRICULUM VITAE Work Address:
Dept. of Internal Medicine University of Rome “Tor Vergata” Via Montpellier 1 00133 Rome, Italy Tel.+39 06 20902262 Fax +39 06 20902357 E-mail: [email protected]Home Address:
Prof. Sergio Bernardini Viale Tito Labieno 122 00174 Rome, Italy Tel. +39 06 71583375
Date of Birth: Marital Status:
1986: Doctor of Medicine, University of Rome "La Sapienza" 1990: Postgraduate specialization in Pediatrics, University of Rome Tor Vergata 1990-1991: Internship at the Department of Endocrinology, Karolinska Sjukhuset, Stockholm 1995: PhD in Paediatrics, University of Rome Tor Vergata 1998: Postgraduate specialization in Clinical Biochemistry, University of Camerino
1997-present: Research consultant in Clinical Biochemistry and Clinical Molecular Biochemistry, Bambino Gesù Children Hospital, Rome. 1998-2001: Researcher in Clinical Biochemistry at the Department of Internal Medicine, University of Rome Tor Vergata.
2000-present: Member of the Professors' Committee for the PhD programme in Biotechnology and Molecular Medicine, University of Rome Tor Vergata. 2002-present: President of undergraduate course in "Diagnostic laboratory techniques in the medical field". 2002-2006: Associate Professor in Clinical Biochemistry at the Department of Internal Medicine, University of Rome Tor Vergata. 2007-present: Full Professor in Clinical Biochemistry at the Department of Internal Medicine, University of Rome Tor Vergata.
Current Teaching Responsibilities Clinical Biochemistry and Clinical Molecular Biology in the following Courses at the University of Tor Vergata, Rome:
• Bachelor course in Diagnostic laboratory techniques in the medical field;
• Degree courses in Medicine, Medical Biotechnologies;
• School of Sport and Exercise Sciences;
• Postgraduate courses in Clinical Biochemistry, Gastroenterology, Neurology,
Medical Genetics, Allergology and Immunology, Paediatrics, Surgery.
From 1984 to 1991 my research focused on paediatric endocrinology with particular interest in growth hormone and insulin like growth factors and their binding proteins, realising the development of methods able to determine the presence, concentration and the physiological secretion patterns of those molecules in different biological fluids. From 1991 to 1998 my studies concentrated on the role of the molecules described above and on retinoids in the apoptotic pathways in oncology, in particular neuroblastoma. Since 1998 I have focused on Glutathione transferases, a family of enzymes involved in cell detoxification and in the control of the programmed cell death. This work has concentrated on the role of those enzymes in the mechanisms responsible for drug resistance depending on changes in the redox status of the cell. As part of this research I have set up and managed a cell and molecular biology laboratory able to perform qRT- PCR and microarray for differential gene expression as well as some applications in Proteomics. Since 2003 I have collaborated in the application of molecular biology methods and techniques in research applied to neurodegenerative diseases, oncology and pharmacogenetics. Since 2009 I have collaborated in the application of molecular biology and biochemical methods to monitoring of sport training and performance. Assistant Work
From 1994 to 1997 I worked as an assistant to the Clinical Biochemistry Laboratory of Bambino Gesù Children Hospital of Rome (head physician Prof. G. Federici). From 2000 to 2006 I managed the Allergology and Autoimmunity sections at the Tor Vergata University Hospital of Rome where I act as the head physician of the Clinical Molecular Biology section. Member of : -Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC) -Italian Society of Allergology and Immunology (SIAIC) -Visiting scientist at the Medical Research Council-Toxicology Unit, Leicester, U.K. Editorial activity: -Editorial Advisory Board Member of The Encyclopedia of Life Sciences, “Biochemistry” section; John Wiley & Sons, Ltd. Publications 2009-2011:
Valentini A, Conforti F, Crispini A, De Martino A, Condello R, Stellitano C, Rotilio G, Ghedini M, Federici G, BERNARDINI S and Pucci D. Oxidant properties and antitumoral effects o fan Heteroleptic Palladium(II) complex of curcumin on human prostate cancer cell. J of Medicinal Chemistry 2009; 52:484-491. Rapanotti MC, Bianchi L, Ricozzi I, Campione E, Pierantozzi A, Orlandi A, Chimenti S, Federici G, BERNARDINI S. Melanoma associated markers expression in blood: MUC-18 is associated with advanced stages in melanoma patients. British J Dermatology 2009;160(2):338-44. Angelucci F, BERNARDINI S, Gravina P, Trequattrini A, Di Iulio F, Vanni D, Federici G, Caltagirone C, Bossù P, Spalletta G. Delusion symptoms and response to antipsychotic treatment are associated with the 5HT2A (102T/C) serotonin receptor polymorphism in Alzheimer’s disease: a 3 years follow-up longitudinal study. J of Alzheimer Disease 2009; 17:203-11. Ciotti M, Marzano V, D’Aguanno S, Giuliani L, Nuccetelli M, Azzimonti B, BERNARDINI S, Perno CF, Urbani A, Favalli C, Federici G. Proteomic investigation in A459 lung cell line stable infected by HPV16E6/E7 oncogenes. Respiration 2009; 77: 427-439 Masini S, Ticconi C, Gravina P, Tomassini M, Pietropolli A, Federici G, Piccione E, BERNARDINI S. Thrombin activable fibrinolisys inhibitor (TAFI) polymorphisms and reccurent pregnancy loss. Fertil Steril. 2009;92:694-702. De Canio M, D’Aguanno S, Sacchetti C, Petrucci F, Cavagni G, Nuccetelli M, Federici G, Urbani A, BERNARDINI S. Recognized Components of Lolium perenne Pollen Extract: Comparative Proteomics Evaluation of Allergic Patients Sensitization Profiles. J Proteome Res. 2009;8:4383-91.
Gravina P, Angelini F, Chianca M, Valentini A, Iannini R, Pierantozzi A, Moschese V, Federici G, Chini L, BERNARDINI S. GSTP1B* allele increases the risk for asthma in italian children. Clin Chem Lab Med 2009 ;47:1451-3. Sancesario G, Esposito Z, Nuccetelli M, BERNARDINI S, Sorge R, Martorana A, Federici G, Bernardi G, Sancesario G. Selective influence of handling temperature on detection of A 42 in the CSF of Alzheimer’s disease: indication of a reversibile processoo f A 42 aggregation? Exp. Neurology 2010;223:371-376. Spalletta G, Morris DW, Angelucci F, Rubino IA, Spoletini I, Bria P, Martinetti G, Siracusano A, Bonaviri G, BERNARDINI S, Caltagirone C, Bossù P, Donohoe G, Gill M, and Corvin AP. BDNF Val66Met polymorphism is associated with overt aggression in schizophrenia. Eur Psychiatry 2010; 25:311-313. Sayan BS, Yang AL, Conforti F, BERNARDINI S, Tucci P, Vasa-Nicotera M, Knight RA, Melino G. Induction of Tap63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010, 22:1748-51
Gaziev J, Spitaleri L, Lucarelli G, Mozzi AF, Nguyen L, Puozzo C, Dannoso Perrone M, Sodani P, Andreani M, Gravina P, Formosa A, Federici G, BERNARDINI S, Marziali M, Isgrò A. Novel Pharmacokinetic behavior of intravenous busulfan in children with talassemia undergoing hematopoietic stem cell transplantation: a prospective eveluation of pharmacokinetic and pharmacodinamic profile with therapeutic drug monitoring. Blood, 2010; 115(22):4597-604. Kalimutho M, Del Vecchio Blanco G, Gravina P, Cretella M, Mannucci L, Mannisi E, Formosa A, Pallone F, Federici G, BERNARDINI S. Quantitative denaturino high performance liquid chromatography (Q-dHPLC) detection of APC Long DNA in faeces from colorectal cancer patients. CCLM 2010; 48(9):1303-11. Liguori PF, Valentini A, Palma MG, Bellusci A, BERNARDINI S, Ghedini M, Panno ML, Pettinari C, Marchetti F, Crispini A, Pucci D. Non classical anticancer agents: synthesis and biological evaluation of zinc(II) heteroleptic complexes. Dalton Trans 2010; 39:4205-4212. Ticconi C, Rotondi F, Veglia M, Pietropolli A, BERNARDINI S, Ria F, Caruso A, Di Simone N. Antinuclear autoantibodies in women with recurrent pregnancy loss. Am J Reprod Immunol 2010; 64(6):384-92. Sayan BS, Li Yang A, Conforti F, Tucci P, Piro C, Browne GJ, Agostini M, BERNARDINI S, Knight RA, Mak TW, Melino G. Differential control of Tap73 and DNp73 protein stability by the ring finger ubiquitin ligase PIR2. PNAS 2010;107:12877-82. D'Aguanno S, Franciotta D, Lupisella S, Barassi A, Pieragostino D, Lugaresi A, Centonze D, D'Eril GM, BERNARDINI S, Federici G, Urbani A. Protein profiling of Guillain-Barrè Syndrome cerebrospinal fluid by two dimensional electrophoresis and mass spectrometry. Neurosci Lett. 2010; 485:49-54. Mori F, Rossi S, Sancesario G, Codecà C, Mataluni G, Monteleone F, Buttari F, Kusayanagi H, Castelli M, Motta C, Studer V, Bernardi G, Koch G, Bernardini S, Centonze D. Cognitive and Cortical Plasticity Deficits Correlate with Altered Amyloid-β CSF Levels in Multiple Sclerosis. Neuropsychopharmacology. 2011;36:559-568. Ricci V, Pomponi M, Martinotti G, Bentivoglio A, Loria G, BERNARDINI S, Caltagirone C, Bria P, Angelucci F. Antidepressant treatment restores Brain-Derived Neurotrophic Factor serum levels and ameliorates motor function in Parkinson disease patients. J Clin Psychopharmacology 2010; 30: 751-753. Rossi S, Buttari F, Studer V, Motta C, Gravina P, Castelli M, Mantovani V, Di Chiara V, Musella A, Fiore S, Masinin S, Bernardi G, Maccarrone M, BERNARDINI S and Centonze D. The (AAT)n repeat of the cannabinoid CB1 receptor gene influences disease progression in relapsing multiple sclerosis. Multiple Sclerosis J 2011; 17:281-288. D'Aguanno S, D'Alessandro A, Pieroni L, Roveri A, Zaccarin M, Marzano V, De Canio M, BERNARDINI S, Federici G, Urbani A. New insights into neuroblastoma cisplatin resistance: a comparative proteomic and meta-mining investigation" Journal of Proteome Research 2011;10:416-428. Ticconi C, Mancinelli F, Gravina P, Federici G, Piccione E, BERNARDINI S. Beta-Fibrinogen G-455 Polymorphisms and recurrent miscarriage. Gynecologic and Obstetric Investigation 2011; 71:198-201. Kalimutho M, Del Vecchio Blanco G, Cretella M, Sileri P, Mannisi E, Mannucci L, Gravina P, Formosa A, Pallone F, Federici G, BERNARDINI S. A non-invasive multi-target Q-dHPLC DNA integrity assay, calprotectin and iFOBT for colorectal cancer detection.
Int J Colorectal Disease. 2011 ; 26:583-592. Donohoe G, Rose E, Frodl T, Morris D, Spoletini I, Adriano F, Bernardini S, Caltagirone C, Bossù P, Gill M, Corvin AP, Spalletta G. ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia. NeuroImage 2011; 54:2132-2137. Angelucci F, Croce N, Spalletta G, Dionallo V, Gravina P, Boss§ P, Federici G, Caltagirone C, BERNARDINI S. Paroxetine rapidly modulates the expression of brain-derived neurotrophic factor mRNA and protein in human glioblastoma-astrocytome cell line. Pharmacology 2011;87:5-10. Cerasa A, Quattrone A, Gioia MC, Magariello A, Muglia M, Assogna F, BERNARDINI S, Caltagirone C, Bossù P, Spalletta G. MAO A VNTR Polymorphism and amygdala volume in healthy subjects. Psychiatry Res 2011; 191:87-91. Viticchiè G, Lena AM, Latina A, Formosa A, Gregersen LH, Lund AH, Bernardini S, Mauriello A, Miano R, Spagnoli LG, Knight RA, Candi E, Melino G. MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle. 2011 Apr 1;10(7). Kalimutho M, Minutolo A,Grelli S, Formosa A, Sancesario G, Valentini A, Federici G, BERNARDINI S. Satraplatin (JM16) modiates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cells: the next generation of oral platinum targets for colorectal cancer treatment. Cancer Chemotherapy and Pharmacology 2011 ; 67:1299-312. Rossi R, Mancino R, Bergami A, Mori F, Castelli M, De Chiara V, Studer V, Mataluni G, Sancesario G, Parisi V, Kasayanagi H, Bernardi G, Nucci C, BERNARDINI S, Martino G, Furlan R, Centonze D. Potential role of IL-13 in nuroprotection and cortical excitability regulation in multiple sclerosis. Multiple Sclerosis 2011 in press. Kalimutho M, Di Cecilia S, Del Vecchio Blanco G, Roviello F, Sileri P, Cretella M, Formosa A, Corso G, Marrelli D, Pallone F, Federici G, BERNARDINI S. Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. British Journal of Cancer 2011; 104: 1770-1778. Mattsson N, Andreasson Ulf, Persson S, Albert M, Arai H, Batish D, BERNARDINI S et al. The Alzheimer’s Association external quality control program for CSF biomarkers. Alzheimer and Dementia 2011 in press Croce N, Dinallo V, Ricci V, Federici G, Caltagirone C, BERNARDINI S, Angelucci F. Neuroprotective effect of neuro peptide Y against Beta-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increate neurotrophin production. Neurodegenerative Diseases 2011; 8: 300-309. Gravina P, Spoletini I, masini S, Valentini A, Vanni D, Paladini E, Bossù P, Caltagirone C, Federici G, Spalletta G, BERNARDINI S. Genteic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factor for schizophrenia. Psychiatric Research 2011; 454-456.
Motherisk Update Health Canada advisory on domperidone Should I avoid prescribing domperidone to women to increase milk production? Pina Bozzo Gideon Koren MD FRCPC FACMT Shinya Ito MD FRCPC Abstract Question I often prescribe domperidone to women as a galactagogue starting at a dose of 30 mg and increasing the dose as needed. In March of this year, Health Canada released an advisory
Copyright 2008 by the American Psychological AssociationIntact Implicit Learning of Spatial Context and Temporal Sequences inCatholic University of America and Georgetown UniversityWilliam D. Gaillard and Chandan J. VaidyaChildren’s National Medical Center and Georgetown UniversityAutism spectrum disorder (ASD) is defined by atypicalities in domains that are posited to rely on implicitlearn