Phs 398 (rev. 9/04), biographical sketch format page

Principal Investigator/Program Director (Last, First, Middle): BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
A. Positions and Honors.
Professional Experience:

Research Assistant, Mechanical & Aerospace Engineering, Cornell University, Ithaca, NY. 1983-1990 Engineering Analyst/Design Engr., Dept. Biomechanics, Hospital for Special Surgery, NY,NY. 1990-1996 Res. Asst., M.I.T. (Cambridge, MA) and Ortho. Biomech. Lab, Beth Israel Hosp. (Boston, MA.) 1996 Post-Doctoral Associate, Massachusetts Institute Technology, Cambridge, MA. 1996-current Director, Biomech. Engr. Lab, Dept. Orthopaedic Surgery, Washington University, St. Louis, MO 1996-1997 Research Instructor, Department Orthopaedic Surgery, Washington University, St. Louis, MO. 1997-2001 Assistant Professor, Department Orthopaedic Surgery, Washington University, St. Louis, MO. Adjunct Professor, Dept. Biomedical Engineering, Washington University, St. Louis, MO Associate Professor, Department Orthopaedic Surgery, Washington University, St. Louis, MO. 2003-current Associate Professor, Dept. Biomedical Engineering, Washington University, St. Louis, MO
2009-current Professor, Department Orthopaedic Surgery, Washington University, St. Louis, MO.
New Investigator Recognition Award, 42nd Annual Meeting, Orthopaedic Research Society Sun Valley Hard Tissue Workshop, Young Investigator Travel Award Lee Ford Award for Academic Achievement, Dept. of Orthopaedic Surgery, Washington Univ. Cabaud Award, American Orthopaedic Society for Sports Medicine Orthop. Res. Society– Workshop Speaker – “Assessing functional skeletal phenotype in mice” 2001 (June) Orthopedics and Musculoskeletal Study Section (ORTH), Center for Scientific Review (CSR), 2002 (Nov.) Special Emphasis Panel, Orthopaedics - Small Business SBIR/STTR Proposals, CSR, NIH. 2003 (Oct) Skeletal Biology Structure and Regeneration Study Section (SBSR), CSR, NIH. 2005-2009 Special Emphasis Panels/Scientific Review Groups; MOSS (Musculoskeletal, Oral and Skin Sciences); CSR, NIH. (April 05, Nov. 05, April 06, Nov. 06, July 09) 2005 (May) NIAMS/ASBMR Bone Quality Meeting – Invited Speaker - “Using Atomic Force Microscopy and Nanoindentation to Assess Bone Material Properties” 2006 (Feb.) NIH/NIAMS Round Table Discussion: “Response of Tissue to Mechanical Stimuli”.
2007-2011 Regular Member, Biology Structure and Regeneration Study Section (SBSR), CSR, NIH.
2008 (Sep.) ASBMR Annual Mtg., Meet-the-Professor, “Bone Imaging & Biomech. for Small Animal Models”
B. Peer-reviewed publications (in chronological order, selected from 96 total).
Silva MJ and Gibson LJ: Modeling the mechanical behavior of vertebral trabecular bone: effects of age-related
changes in microstructure. Bone 21:191-199, 1997 Silva MJ, Keaveny TM and Hayes WC. Computed tomography-based finite element analysis predicts failure
loads and fracture patterns for vertebral sections. J. Orthop. Res., 16:300-308, 1998 Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle): Gelberman RH, Boyer MI, Brodt MD, Winters SC, and Silva MJ. The effect of repair site gap formation on the
strength and excursion of intrasynovial flexor tendons: an experimental study on the early stages on tendon healing in dogs. J. Bone Jt. Surg [Am], 81:975-982, 1999 Brodt MD, Ellis CB, and Silva MJ. Growing C57BL/6 mice increase whole bone mechanical properties by
increasing geometric and material properties. J. Bone Min. Res. 14:2159-2166, 1999 Boyer MI, Gelberman RH, Burns ME, Dinopoulos H, Hofem R, Silva MJ. Intrasynovial flexor tendon repair: an
experimental study on low versus high levels of in vivo force rehabilitation in canines. J Bone Joint Surg 83A(6):891-899, 2001 Hsieh Y-F and Silva MJ. In vivo fatigue loading of the rat ulna induces both bone formation and resorption and
leads to time-related changes in bone mechanical properties and density. J Orthop Res 20:764-771, 2002. Silva, MJ, Brodt MD, Wopenka B, Thomopoulos S, Williams DE, Wassen MH, Ko M, Kusano N, Bank RA.
Decreased collagen organization and content are associated with reduced material strength of demineralized and intact bone in the SAMP6 mouse. J Bone Miner Res, 21:78-88, 2006. Silva MJ, Thomopoulos S, Kusano N, Zaegel MA, Harwood FL, Matsuzaki H, Havlioglu N, Dovan TT, Amiel D,
Gelberman RH. Early healing of flexor tendon insertion site injuries: tunnel repair is mechanically and histologically inferior to surface repair in a canine model. J Orthop Res 24(5): 990-1000, 2006. Uthgenannt BA, Silva MJ. Use of the rat forelimb compression model to create discrete levels of bone
damage in vivo. J Biomech, 40(2):317-24, 2007. Thomopoulos S, Matsuzaki H, Zaegel M, Gelberman RH, Silva MJ. Alendronate prevents bone loss and
improves tendon to bone repair strength in a canine model. J Orthop Res, 25(4):473-9, 2007. Matsuzaki H, Wohl GR, Novack DV, Lynch JA, Silva MJ. Damaging Fatigue Loading Stimulates Rapid Increases
in Vascularity at Sites of Bone Formation in the Rat Ulna. Calcif Tiss Int, 80(6):391-9, 2007. Thomopoulos S, Zaegel M, Das R, Harwood FL, Silva MJ, Amiel D, Sakiyama-Elbert S, Gelberman RH. A
novel method for growth factor delivery in tendon repair: Enhanced healing through sustained delivery of PDGF-BB. J Orthop Res, 25(10):1358-68, 2007. Uthgenannt BA, Kramer MH, Hwu JA, Wopenka B, Silva MJ. Skeletal Self-Repair: Stress Fracture Healing by
Rapid Formation and Densification of Woven Bone. J Bone Miner Res, 22(10): 1548-56, 2007. Grimston SK, Brodt MD, Silva MJ, Civitelli R. Attenuated Response to in vivo Mechanical Loading in Mice with
Conditional Osteoblast Ablation of the Connexin43 Gene (Gja1). J Bone Miner Res, 23(6):879-86, 2008. Ramanadham S, Yarasheski KE, Silva MJ, Wohltmann M, Veis-Novack D, Christiansen B, Lei X, Turk J. Age-
Related Changes in Bone Morphology are Accelerated in Group VIA Calcium-Independent Phospholipase A β 2 (iPLA2 )-Null Mice. Am. J. Pathology, 172(4):868-81, 2008. Thomopoulos S, Zampiakis E, Das R, Silva MJ, Gelberman RH. The Effect of Muscle Loading on Flexor
Tendon-to-Bone Healing in a Canine Model. J Orthop Res, 26(12):1611-7, 2008. Silva MJ, Brodt MD. Mechanical Stimulation of Bone Formation is Normal in the SAMP6 Mouse. Calcified
Tissue International, 82(6):489-97, 2008. Reich MS, Jarvis JP, Silva MJ, Cheverud JM. Genetic relationships between obesity and osteoporosis in
LGXSM recombinant inbred mice. Genetic Res., 90(5):433-44, 2008. Wohl GR, Towler DA, Silva MJ. Stress Fracture Healing: Fatigue Loading of the Rat Ulna Induces
Upregulation in Expression of Osteogenic and Angiogenic Genes that Mimic the Intramembranous Portion of Fracture Repair. Bone, 44(2):320-330, 2009. Silva MJ, Brodt MD, Lynch MA, McKenzie JA, Tanouye KM, Nyman J, Wang X. Type 1 Diabetes in Young
Rats Leads to Progressive Trabecular Bone Loss, Cessation of Cortical Bone Growth and Diminished Whole-Bone Strength and Fatigue Life. J. Bone Miner. Res., [Epub 2009 Apr 1]. 24(9):1618-27, 2009. Lynch MA, Brodt MD, Silva MJ. Skeletal Effects of Whole-Body Vibration in Adult and Aged Mice. J. Orthop.
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