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Curriculum vitae – tania kotsos

Curriculum Vitae – Lamprinidis George
Personal Data
Akropoleos 40, Alimos 174-55, Athens, Greece Education

UNIVERSITY DEGREES

POSTGRADUATE STUDIES:
University of Athens – Greece
Faculty of Pharmacy – Department Pharmaceutical Chemistry
Panepistimiopolis, Zografou, Athens, 15771, Greece
Doctor of Philosophy – Pharmaceutical chemistry (PhD) - 2005
Thesis Title “Molecular Mechanic Simulations Studies of the Estrogen Receptor -
Design, Synthesis, in vitro and in silico evaluation of new Raloxifene Analogs.
University of Athens – Greece
Faculty of Pharmacy – Department Pharmaceutical Chemistry
Panepistimiopolis, Zografou, Athens, 15771, Greece
Masters in Science Pharmaceutical chemistry (MSc) - 2000
University of Athens – Greece
Faculty of Pharmacy
Panepistimiopolis, Zografou, Athens, 15771, Greece
Degree in Pharmacy - 1998

OTHER QUALIFICATIONS AND FURTHER EDUCATION

1995
Training at the laboratory of Pr. Serge Perez, INRA-Nantes, France. Molecular simulations Studies on oligosaccharides (3 months, Erasmus programme) Training at the Pharmaceutical Industry Novartis, N.Jersey U.S.A. on R&D Department. Molecular Modeling Simulations for drug design and receptor-ligand recognition, guided by Dr. Istvan Kollosvary and Dr. Wayne Guida. (1 month) Licence to practice Pharmacy, Ministry of Health, Greece. 2 weeks training at Pharmaceutical Industry “Medochemie” Limassol, Cyprus. Scale up synthesis of raw materials Assisting on Structure– & Computer– Aided Design Workshop: Bioactive Molecules & Materials, 7 – 11 November, 2011, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation Participation on the “Cyprus Advanced HPC Winter Workshop 2012” 6-9 February 2012, The Cyprus Institute, Athalassa Campus - Nicosia, Cyprus Publications
1. E. Mikros, G. Lambrinidis & S. Perez, "Conformational analysis of C-disaccharides using molecular mechanics calculations", J. Carbohydr. Chem., 2000, 19, 1319-1349.
2. Harvala E, Aligiannis N, Skaltsounis AL, Pratsinis H, Lambrinidis G, Harvala C, Chinou I., «Cytotoxic germacranolides from Inula verbascifolia subsp. methanea.», J Nat Prod. 2002, 7, 1045-8.
3. Emmanuel Mikros; George Lambrinidis; Serge Pérez «Conformational Analysis of C-Trehaloses Using Molecular Mechanics Calculations”, J. Carbohydr. Chem., 2003, 22 , 407 – 421.
4. Zoumpoulakis P, Daliani I, Zervou M, Kyrikou I, Siapi E, Lamprinidis G, Mikros E, Mavromoustakos T. Losartan's molecular basis of interaction with membranes and AT(1) receptor, CHEMISTRY AND PHYSICS OF LIPIDS, 125 (1):
13-25 SEP 2003
5. Nikolas Fokialakis, George Lambrinidis, Dimitra J. Mitsiou, Nektarios Aligiannis, Sofia Mitakou, Alexios-Leandros Skaltsounis, Harris Pratsinis, Emmanuel Mikros and Michael N. Alexis “A New Class of Phytoestrogens: Evaluation of
the Estrogenic Activity of Deoxybenzoins”, Chemistry & Biology, 2004, 11, 397-406
6. Lambrinidis G, Halabalaki M, Katsanou ES, Skaltsounis AL, Alexis MN, Mikros E. The estrogen receptor and polyphenols: molecular simulation studies of their interactions, a review. ENVIRONMENTAL CHEMISTRY LETTERS 4 (3): 159-174 AUG 2006
7. Halabalaki M, Alexi X, Aligiannis N, Lambrinidis G, Pratsinis H, Florentin I, Mitakou S, Mikros E, Skaltsounis AL, Alexis MN Estrogenic activity of isoflavonoids from Onobrychis ebenoides, PLANTA MEDICA ,72 (6): 488-493 MAY 2006
8. Papoutsi, Z., Kassi, E., Fokialakis, N., Mitakou, S., Lambrinidis, G., Mikros, E., Moutsatsou, P. Deoxybenzoins are novel potent selective estrogen receptor modulators. Steroids, 72 (9-10), pp. 693-704, 2007.
9. Alexi, X., Kasiotis, K.M., Fokialakis, N., Lambrinidis, G., Meligova, A.K., Mikros, E., Haroutounian, S.A., Alexis, M.N. Differential estrogen receptor subtype modulators: Assessment of estrogen receptor subtype-binding selectivity and
transcription-regulating properties of new cycloalkyl pyrazoles (2009) Journal of Steroid Biochemistry and Molecular
10. A substrate translocation trajectory and channel-like gating in a eukaryotic member of the Nucleobase-Ascorbate transporter (NAT) family, V. Kosti, G. Lambrinidis, V. Myrianthopoulos, G. Diallinas, and E. Mikros, Journal of
Molecular Biology (submitted)
11. Design, Synthesis and Molecular Simulations Studies of Dihydrostilbene Derivatives as Potent Tyrosinase Inhibitors Argyro Vontzalidou, Grigoris Zoidis, Eliza Chaita, Maria Makropoulou, Nektarios Aligiannis, George Lambrinidis,
Emmanuel Mikros, Alexios-Leandros Skaltsounis. European Journal of Medicinal chemistry (submitted)
12. QSAR Analysis of PPAR-α/γ Activity using Multivariate Statistics and Molecular Simulation. Theodosia Vallianatou, George Lambrinidis, Costas Giaginis, Emmanuel Mikros and Anna Tsantili-Kakoulidou. European Journal of Medicinal chemistry (submitted)
13. Synthesis, Molecular Modeling and Biological Evaluation of Carbonyl Analogues of Tamoxifen (in preparation)
14. Design, Synthesis, Molecular Modeling and Biological Evaluation of New Analogs of Raloxifene (in preparation)
Presentations
1. Binding Affinities of Estradiol and Raloxifene Analogues to Estrogen Receptor Using Molecular Mechanics Simulation Lamprinidis G., and Mikros E. AIMECS 99 International Medicinal Chemistry Symposium, September 1999, Beijing China
2. Isoflavones and benzofurans from Onobrychis ebenoides and evaluation of their estrogenic activity M. Halabalaki, N. Aligiannis, H. Pratsinis, G. Labrinidis, E. Mikros, S Mitakou and A. L Skaltsounis.
PSE Symposium, Lausanne, Switzerland, 2001
Μ. Halabalaki, Ν. Αligiannis, H. Pratsinis, G. Labrinidis, P. Marakos, S. Μitakou and Α. L. Skaltsounis
10th National Pharmaceutical Conference, Athens, 2001
4. Design, Synthesis, in vitro and in silico evaluation of Raloxifene analogs. Lamprinidis G., Marakos. P., Pouli N., Mikros. E., Alexis M.N. 11o Panhellenic Pharmaceutical Congress, Athens 2003
5. in silico rational drug design. The case of Estrogen Receptor. Lamprinidis G., Marakos. P., Pouli N., Mikros. E., Alexis M.N. 9th Scientific Congress of Students of Medical School, Greece, 2003
6. The Estrogen Receptor and Polyphenols: Molecular Simulation Studies of their Interaction (Plenary Lecture) George Lambrinidis and Emmanuel Mikros
XXII International Conference on Polyphenols, Helsinki, 2004.
7. Molecular Simulation Studies of Estrogen Receptor. Design and Synthesis of New Analogues of Raloxifene. George Lamprinidis, Maria Halabalaki,Nikolas Fokialakis, Efrosini S. Katsanou, Alexios-Leandros Skaltsounis, Michael European School of Medicinal Chemistry, Urbino July 2005
8. Molecular Simulation Studies of Estrogen Receptor. Design and Synthesis of New Analogues of Raloxifene. George Lambrinidis, Maria Halabalaki, Nikolas Fokialakis, Efrosini S. Katsanou, Alexios-Leandros Skaltsounis,
Michael N. Alexis Panagiotis Marakos, Nicole Pouli and Emmanuel Mikros
12th International Congress on Hormonal Steroids and Hormones & Cancer, Athens, September 2006
9. Differential estrogen receptor modulators: assessment of estrogen receptor binding selectivity and transcriptional modulation bias Alexi X., Kasiotis K. M., Fokialakis N., Lambrinidis G.Meligova A. K., Mikros E., Haroutounian, S.
Alexis, M. N.
33rd FEBS Congress & 11th IUBMB Conference, June 28-July 3, 2008, Athens FEBS J., 2008, Suppl. 275, 157.
10. Molecular Simulation Studies of Ligand Binding to Estrogen Receptor. Prediction Models fo affinity, selectivity and biological response. Lambrinidis George, Skaltsounis Alexios Leandros, Marakos Panagiotis, Pouli Nicole, Alexis Michael N., Mikros 18th EuroQSAR, 19-24 September 2010, Rhodes-Greece
11. “From genetic data to 3D models. Structure activity relationship of UapA transporter”. Kosti V. Lambrinidis G., Myrianthopoulos V., Diallinas G., Mikros E.
4th Congress of Scientific Initiative Mikrobiokosmos, Ioannina,Greece 2011
12. Development of Synthetic Deoxybenzoins and Dihydrostilbenes as potential Tyrosinase inhibitors” . Vontzalidou Argyro , Zoidis Grigoris, Chaita Eliza, Makropoulou Maria, Aligiannis Nektarios, Lambrinidis Georgios, Mikros
Emmanuel, Skaltsounis Alexios-Lenadros.
1st Congress of Pharmaceutical Sciences, Athens Greece 2012.
Work experience
3 months working experience as a Pharmacist at Hippocratio University Hospital, Athens, Greece. 3 months working experience as a Pharmacist at Pharmaceutical Industry “ELPEN”, on Quality Control Depertment. 1998-1999:
9 months working experience as a Pharmacist at pharmacy open to the public. Participation in the scientific programme ΠΕΝΕΔ as researcher (10 months), at the Pharmaceutical Industry “ELPEN” in collaboration with the Faculty of Pharmacy 2001 - 2003: Technical Support in Faculty of Pharmacy for the European Programs ΕΠΕΑΕΚ “Production and Quality
Control of Pharmaceutical Substances”. 2003 - 2004
2005 - 2007
Technical Support in Faculty of Pharmacy for the European Programs ΕΠΕΑΕΚ “Post Graduate Studies Reformation, for the Faculty of Pharmacy of NKUA, emphasising in new technologies-multimedia on education» 2007 - today Researcher - Laboratory assistant at the Faculty of Pharmacy, National and Kapodistrian University of
2009-2011:
Lecture for two years (Π/Δ 407), Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens  Research skills
 Nuclear Magnetic Resonance (NMR) Spectroscopy 1D and 2D  Molecular Mechanics-based docking calculations.  Molecular Dynamics simulations  Free Energy Perturbation (FEP) calculations  Ab-initio quantum-mechanics (QM) computations  Optimized Virtual Screening (VS) protocols  Bioinformatics tools (sequence analysis, homology model construction and validation)  Pharmacophore and similarity searching, fingerprint analysis and screening  Design and administration of fully automated chemical inventories, both in their virtual and physical forms.  Computing
Schrodinger suite 2011, Desmond , Amber, Openeye suite , e-Hits , chimera , Autodock , Gromacs , Modeller Gaussian , Chemaxon, Prgen  Languages
Achievements
 Poster Award on EuroQSAR 2010, “Molecular Simulation Studies of Ligand Binding to Estrogen Receptor. Prediction
Models for affinity, selectivity and biological response.”  Poster Award on 1st Congress of Pharmaceutical Sciences, Athens Greece 2012, “Development of Synthetic
Deoxybenzoins and Dihydrostilbenes as potential Tyrosinase inhibitors” Memberships
 Hellenic Pharmaceutical Assosiation (EFE)  Panhellenic Association of Pharmacists  Member of the Theatrical Group of “Estia Neas Smyrnis”.  “Second Cantar (Lampadarios) on local church, Assumption of Mary (Koimisis theotokou) Alimou.

Source: http://biospec.pharm.uoa.gr/CV/cv-lamprinidis.pdf

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